Detailed information for compound 1862481

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 543.316 | Formula: C24H27Cl4N5O
  • H donors: 0 H acceptors: 2 LogP: 6.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1cccc(c1)N1CCN(CC1)CCCn1cnc2c(c1=O)cnc1c2cccc1.Cl.Cl.Cl
  • InChi: 1S/C24H24ClN5O.3ClH/c25-18-5-3-6-19(15-18)29-13-11-28(12-14-29)9-4-10-30-17-27-23-20-7-1-2-8-22(20)26-16-21(23)24(30)31;;;/h1-3,5-8,15-17H,4,9-14H2;3*1H
  • InChiKey: XTZGZLVGMPTHPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0015 0.0027
Leishmania major trypanothione reductase 0.0156 0.115 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0219 0.025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0042 0.0075
Echinococcus multilocularis dna polymerase eta 0.0093 0.0641 0.0958
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.021 0.1827
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0024 0.0043
Leishmania major DNA polymerase eta, putative 0.0065 0.0416 0.3617
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.054 1
Brugia malayi conserved hypotetical protein 0.0019 0.0042 0.0048
Brugia malayi nuclear receptor NHR-67 0.0019 0.0042 0.0048
Plasmodium vivax SET domain protein, putative 0.0157 0.1158 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0219 0.0327
Schistosoma mansoni tar DNA-binding protein 0.0337 0.2625 0.4683
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0377 0.0673
Schistosoma mansoni nuclear receptor 0.0019 0.0042 0.0075
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0054 0.0322 0.0367
Brugia malayi MH2 domain containing protein 0.0254 0.195 0.2223
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0904 0.1613
Loa Loa (eye worm) hypothetical protein 0.007 0.0456 0.052
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.011 0.0955
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.008 0.0884
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.025
Mycobacterium tuberculosis Probable reductase 0.0355 0.2772 0.8958
Trypanosoma brucei unspecified product 0.0028 0.0109 0.0946
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1118 0.1671
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0017
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0015 0.0023
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0677 0.1207
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0065 0.0416 0.3589
Giardia lamblia DINP protein human, muc B family 0.004 0.021 0.3103
Plasmodium vivax thioredoxin reductase, putative 0.0156 0.115 0.9924
Loa Loa (eye worm) hypothetical protein 0.0053 0.0318 0.0363
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0149 0.017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0322 0.2803
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0015 0.0023
Echinococcus granulosus phd:f box containing protein 0.0016 0.0015 0.0027
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0183 0.0183
Schistosoma mansoni microtubule-associated protein tau 0.0703 0.5605 1
Schistosoma mansoni hypothetical protein 0.007 0.0456 0.0814
Schistosoma mansoni hypothetical protein 0.0228 0.1739 0.3102
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0677 0.5887
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0582 0.1038
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0247 0.2129
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0133
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0061 0.0091
Brugia malayi Thioredoxin reductase 0.0156 0.115 0.1311
Echinococcus multilocularis protein patched 0.0044 0.0238 0.0356
Schistosoma mansoni ap endonuclease 0.002 0.0044 0.0078
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.021 0.0314
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0377 0.0564
Onchocerca volvulus 0.0096 0.0665 0.0665
Brugia malayi hypothetical protein 0.0156 0.1152 0.1314
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.0526 0.0526
Brugia malayi nuclear receptor RXR 0.0019 0.0042 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0157 0.1158 0.2067
Onchocerca volvulus 0.0051 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.025
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1234 0.1844
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0061 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0219 0.025
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.025
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0015 0.0027
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0015 0.0132
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0723 0.129
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0219 0.025
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0044 0.0381
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0183 0.0183
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0042 0.0048
Trichomonas vaginalis glutathione reductase, putative 0.0054 0.0322 0.0322
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0054 0.0322 0.3564
Plasmodium falciparum glutathione reductase 0.0156 0.115 1
Brugia malayi glutathione reductase 0.0156 0.115 0.1311
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0322 0.2803
Loa Loa (eye worm) hypothetical protein 0.0297 0.2303 0.2625
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0219 0.0391
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.1234 0.1407
Trypanosoma brucei glucosidase, putative 0.0037 0.0183 0.1594
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0377 0.0673
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0015 0.0133
Plasmodium falciparum glutathione reductase 0.0054 0.0322 0.2803
Plasmodium falciparum thioredoxin reductase 0.0156 0.115 1
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0219 0.0391
Brugia malayi Probable ClpP-like protease 0.0081 0.054 0.0616
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0247 0.2129
Brugia malayi nuclear receptor NHR-88 0.0019 0.0042 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0015 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Toxoplasma gondii thioredoxin reductase 0.0156 0.115 0.9924
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.008 0.069
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0577 0.3319
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0061 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0219 0.025
Brugia malayi hypothetical protein 0.0022 0.0061 0.0069
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.054 0.4699
Brugia malayi Pre-SET motif family protein 0.1092 0.8772 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0042 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0377 0.043
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.004 0.0206 0.0235
Echinococcus multilocularis smad 0.0017 0.0024 0.0036
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.071 0.081
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0054 0.0322 0.2782
Echinococcus granulosus histone lysine methyltransferase setb 0.0157 0.1158 0.2067
Echinococcus multilocularis geminin 0.0177 0.1327 0.1983
Onchocerca volvulus 0.0156 0.1152 0.1152
Trypanosoma cruzi trypanothione reductase, putative 0.0156 0.115 1
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0183 0.0183
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0149 0.017
Leishmania major DNA polymerase eta, putative 0.0093 0.0641 0.5575
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0015 0.0027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0349 0.2727 0.4074
Trypanosoma cruzi DNA polymerase eta, putative 0.0093 0.0641 0.5575
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0061 0.0108
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.008 0.0695
Brugia malayi ImpB/MucB/SamB family protein 0.0093 0.0641 0.0731
Onchocerca volvulus 0.0157 0.1158 0.1158
Schistosoma mansoni hypothetical protein 0.0033 0.0149 0.0265
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0395 0.3094 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0355 0.2772 0.8958
Echinococcus granulosus ubiquitin specific protease 41 0.0079 0.0526 0.0938
Echinococcus multilocularis microtubule associated protein 2 0.0703 0.5605 0.8375
Loa Loa (eye worm) hypothetical protein 0.0157 0.1158 0.1321
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0079 0.0526 0.0938
Entamoeba histolytica hypothetical protein 0.0228 0.1739 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.025
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.054 0.5974
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0247 0.2129
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0677 0.0772
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0238 0.0272
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0054 0.0322 0.0575
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0322 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0219 0.025
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0042 0.0075
Trichomonas vaginalis set domain proteins, putative 0.1243 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0904 0.1613
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.0526 0.0526
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.021 0.1827
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0042 0.0075
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0054 0.0322 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0219 0.025
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0904 0.7807
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0015 0.0027
Schistosoma mansoni biogenic amine (5HT) receptor 0.015 0.1104 0.1969
Loa Loa (eye worm) RNA binding protein 0.0337 0.2625 0.2992
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0183 0.1594
Leishmania major hypothetical protein, conserved 0.0026 0.0095 0.0828
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0238 0.0356
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0017
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0054 0.0322 0.2803
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0219 0.0327
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.1065 0.19
Brugia malayi hypothetical protein 0.0017 0.002 0.0023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0149 0.0265
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0677 0.1011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0219 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0157 0.1158 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0365 0.0416
Giardia lamblia NADH oxidase lateral transfer candidate 0.0054 0.0322 0.4762
Loa Loa (eye worm) hypothetical protein 0.0081 0.054 0.0616
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.008 0.0884
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.008 0.1479
Trichomonas vaginalis mercuric reductase, putative 0.0054 0.0322 0.0322
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.021 0.1827
Schistosoma mansoni tar DNA-binding protein 0.0337 0.2625 0.4683
Brugia malayi hypothetical protein 0.0019 0.0042 0.0048
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0904 0.1351
Schistosoma mansoni tar DNA-binding protein 0.0337 0.2625 0.4683
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0095 0.0822
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.054 1
Echinococcus granulosus tumor protein p63 0.0349 0.2721 0.4854
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0904 0.2923
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0044 0.0381
Echinococcus multilocularis ubiquitin specific protease 41 0.0079 0.0526 0.0786
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0157 0.1158 0.2067
Loa Loa (eye worm) hypothetical protein 0.0044 0.0238 0.0272
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.021 0.0375
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0042 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0219 0.025
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0042 0.0075
Echinococcus granulosus dna polymerase kappa 0.004 0.021 0.0375
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0044 0.0141
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.021 0.0679
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0365 0.0652
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0042 0.0062
Echinococcus multilocularis dna polymerase kappa 0.004 0.021 0.0314
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.025
Schistosoma mansoni transcription factor LCR-F1 0.0228 0.1739 0.3102
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1234 0.1844
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0219 0.0391
Schistosoma mansoni nuclear receptor 0.0019 0.0042 0.0075
Mycobacterium tuberculosis Probable dehydrogenase 0.0355 0.2772 0.8958
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0219 0.0391
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0219 0.0327
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0157 0.1158 0.2067
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0219 0.0391
Trypanosoma brucei unspecified product 0.0028 0.0109 0.0946
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0042 0.0062
Onchocerca volvulus 0.0019 0.0042 0.0042
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.021 0.021
Brugia malayi MH1 domain containing protein 0.0017 0.0024 0.0028
Schistosoma mansoni alpha glucosidase 0.0037 0.0183 0.0327
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0183 0.1054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1092 0.8772 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0079 0.0526 0.0786
Loa Loa (eye worm) glutathione reductase 0.0156 0.115 0.1311
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.008 0.1479
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0722 0.0823
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0044 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0157 0.1158 0.2067
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0247 0.044
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0044 0.0044
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0183 0.0183
Entamoeba histolytica hypothetical protein 0.0228 0.1739 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.054 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0904 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0015 0.0027
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0377 0.0564
Loa Loa (eye worm) DR-78 0.0019 0.0042 0.0048
Loa Loa (eye worm) hypothetical protein 0.015 0.1104 0.1258
Brugia malayi MH1 domain containing protein 0.0017 0.0024 0.0028
Brugia malayi jmjC domain containing protein 0.0061 0.0377 0.043
Schistosoma mansoni alpha-glucosidase 0.0143 0.1046 0.1867
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0299 0.0533
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0183 0.0274
Loa Loa (eye worm) thioredoxin reductase 0.0156 0.115 0.1311
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0526 0.0526
Echinococcus multilocularis GPCR, family 2 0.0033 0.0149 0.0222
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0183 0.0209
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0247 0.0247
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0079 0.0526 0.0938
Echinococcus multilocularis protein dispatched 1 0.005 0.0288 0.0431
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.1234 0.1407
Schistosoma mansoni coup transcription factor 0.0041 0.0219 0.0391
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.004 0.0206 0.0235
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.021 0.0375
Mycobacterium tuberculosis Probable oxidoreductase 0.0395 0.3094 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0042 0.0042
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0042 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Echinococcus multilocularis muscleblind protein 0.0297 0.2303 0.344
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0017
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0355 0.2772 0.8958
Loa Loa (eye worm) hypothetical protein 0.0085 0.0577 0.0658
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0044 0.005
Echinococcus granulosus biogenic amine 5HT receptor 0.015 0.1104 0.1969
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0183 0.0183
Brugia malayi MH2 domain containing protein 0.0017 0.0024 0.0028
Echinococcus granulosus dna polymerase eta 0.0093 0.0641 0.1143
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0017
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0054 0.0322 0.3564
Echinococcus granulosus thioredoxin glutathione reductase 0.0158 0.1167 0.2081
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0355 0.2772 0.8958
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0042 0.0062
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0395 0.3094 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0526 0.4574
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0216 0.1883
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0183 0.0183
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0149 0.017
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0015 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0677 0.0677
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0322 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0054 0.0322 0.5965
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0219 0.0327
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0042 0.0048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0322 0.2803
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0219 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0219 0.025
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.025
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0054 0.0322 0.1042
Trypanosoma brucei trypanothione reductase 0.0156 0.115 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.021 0.0375
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0904 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0219 0.0327
Leishmania major DNA polymerase kappa, putative 0.004 0.021 0.1827
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0219 0.0391
Brugia malayi hypothetical protein 0.0022 0.0061 0.0069
Brugia malayi ecdysteroid receptor 0.0041 0.0219 0.025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0219 0.0391
Loa Loa (eye worm) TAR-binding protein 0.0337 0.2625 0.2992
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0365 0.4039
Echinococcus multilocularis Smad4 0.0017 0.0024 0.0036
Loa Loa (eye worm) hypothetical protein 0.0297 0.2303 0.2625
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.054 0.0964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0219 0.025
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.008 0.0695
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0015 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0061 0.0069
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0044 0.0378
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0079 0.0526 0.7769
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0904 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0677 0.0677
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0054 0.0322 0.2803
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0219 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0109 0.0946
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0456 0.052
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0042 0.0048
Schistosoma mansoni hypothetical protein 0.0177 0.1327 0.2368
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0219 0.0327
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0044 0.081
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0157 0.1158 0.1731
Plasmodium vivax glutathione reductase, putative 0.0156 0.115 0.9924
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0044 0.0484
Schistosoma mansoni patched 1 0.0044 0.0238 0.0425
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0095 0.0828
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0219 0.0327
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0054 0.0322 0.2803
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.021 0.1208
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0061 0.0108
Schistosoma mansoni hypothetical protein 0.0177 0.1327 0.2368
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.021 0.0239
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.042 0.33 0.3761
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0044 0.0381
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0044 0.081
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0582 0.0869
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0314 0.1015
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0219 0.0327
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0228 0.1739 0.3102
Schistosoma mansoni smad1 5 8 and 0.0017 0.0024 0.0043
Brugia malayi nuclear hormone receptor 0.0041 0.0219 0.025
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0677 0.5887
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0054 0.0322 0.3564
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0219 0.0391
Brugia malayi MH2 domain containing protein 0.0017 0.0024 0.0028
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.054 0.0807
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.021 0.1827
Onchocerca volvulus 0.0086 0.0582 0.0582
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0042 0.0048
Toxoplasma gondii exonuclease III APE 0.002 0.0044 0.0378
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0042 0.0075
Mycobacterium leprae conserved hypothetical protein 0.0024 0.008 0.0258
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0228 0.1739 0.2598
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0095 0.0828
Schistosoma mansoni ap endonuclease 0.002 0.0044 0.0078
Echinococcus multilocularis tumor protein p63 0.0349 0.2721 0.4065
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.008 0.069
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.021 0.1827
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0042 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0219 0.025
Brugia malayi Muscleblind-like protein 0.0297 0.2303 0.2625
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0677 0.0677
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0054 0.0322 0.2803
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0219 0.0391
Echinococcus granulosus tar DNA binding protein 0.0337 0.2625 0.4683
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0219 0.025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0151 0.1112 0.1983
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0069
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0183 0.1054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0322 0.2803
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.008 0.0695
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.054 0.1746
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0069
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0582 0.1038
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.008 0.1479
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.021 0.0239
Treponema pallidum NADH oxidase 0.0054 0.0322 0.5965
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0095 0.0828
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.011 0.0355
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.054 0.4664
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.021 0.1827
Brugia malayi TAR-binding protein 0.0337 0.2625 0.2992
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0276 0.0276
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.011 0.2032
Brugia malayi hypothetical protein 0.0228 0.1739 0.1982
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0015 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0044 0.0381
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0044 0.0044
Echinococcus granulosus Smad4 0.0017 0.0024 0.0043
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0015 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0837 0.6693 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0042 0.0062
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0219 0.0391
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0079 0.0526 0.0938
Loa Loa (eye worm) hypothetical protein 0.0086 0.0582 0.0663
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.054 0.0964
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.011 0.0948
Echinococcus granulosus GPCR family 2 0.0033 0.0149 0.0265
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.054 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0158 0.1167 0.1743
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0219 0.0391
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.071 0.1061
Brugia malayi RNA recognition motif domain containing protein 0.0337 0.2625 0.2992
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0722 0.0823
Echinococcus multilocularis tar DNA binding protein 0.0337 0.2625 0.3922
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.1084 0.1933
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0054 0.0322 0.2803
Brugia malayi Pre-SET motif family protein 0.0157 0.1158 0.1321
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0219 0.025
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0314 0.0469
Onchocerca volvulus 0.0041 0.0219 0.0219
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0314 0.1015
Brugia malayi nuclear receptor NHR-88 0.0041 0.0219 0.025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0337 0.2625 0.2992
Schistosoma mansoni hypothetical protein 0.0042 0.0226 0.0402
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.071 0.1267
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0904 0.1613
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Loa Loa (eye worm) hypothetical protein 0.0156 0.1152 0.1314
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.1065 0.1591
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0219 0.0391
Toxoplasma gondii hypothetical protein 0.0028 0.011 0.0948
Leishmania major hypothetical protein, conserved 0.0016 0.0015 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0276 0.0276
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0183 0.0183
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0677 0.3892
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0054 0.0322 0.5965
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0365 0.0546
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0183 0.1594
Mycobacterium ulcerans DNA polymerase IV 0.004 0.021 0.2322
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0079 0.0526 0.3024
Schistosoma mansoni tar DNA-binding protein 0.0337 0.2625 0.4683
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0024 0.0028
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0015 0.0132
Brugia malayi Smad1 0.0017 0.0024 0.0028
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0216 0.3198
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.021 0.0679
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0219 0.025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0365 0.4039
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0677 0.0677
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0079 0.0526 0.0599
Echinococcus multilocularis serotonin receptor 0.015 0.1104 0.1649
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0677 0.0772
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0109 0.0946
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.008 0.0258
Schistosoma mansoni hypothetical protein 0.0033 0.0149 0.0265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0054 0.0322 0.2803
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0042 0.0075
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0219 0.0391
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0355 0.2772 0.8958
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0133
Brugia malayi tailless protein 0.0019 0.0042 0.0048
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0069
Loa Loa (eye worm) hypothetical protein 0.0102 0.071 0.081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0095 0.0109
Schistosoma mansoni hypothetical protein 0.0033 0.0149 0.0265
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0024 0.0043
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0133
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0355 0.2772 0.8958
Loa Loa (eye worm) hypothetical protein 0.0079 0.0526 0.0599
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0377 0.0673
Schistosoma mansoni kinase 0.005 0.0287 0.0511
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0149 0.0222
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0054 0.0322 0.5965
Loa Loa (eye worm) hypothetical protein 0.0033 0.0149 0.017
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0577 0.3319
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0044 0.0252
Schistosoma mansoni hypothetical protein 0.0042 0.0226 0.0402
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0044 0.005
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0042 0.0048
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0238 0.0425
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.1234 0.2202
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0069
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0109 0.0946
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.054 0.5974
Schistosoma mansoni hypothetical protein 0.0033 0.0149 0.0265
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.008 0.069
Onchocerca volvulus 0.0019 0.0042 0.0042
Brugia malayi CHE-14 protein 0.0044 0.0238 0.0272
Schistosoma mansoni smad1 5 8 and 0.0017 0.0024 0.0043
Echinococcus multilocularis serotonin receptor 0.015 0.1104 0.1649
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0395 0.3094 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.1827
Giardia lamblia Kinase, PLK 0.0097 0.0677 1
Echinococcus granulosus muscleblind protein 0.0297 0.2303 0.4108
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0095 0.0828
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0219 0.0391
Loa Loa (eye worm) Smad1 0.0017 0.0024 0.0028
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0238 0.0425
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0219 0.025
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.021 0.1827
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0054 0.0322 0.2803
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0349 0.2727 0.4865
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0069
Plasmodium falciparum thioredoxin reductase 0.0054 0.0322 0.2803
Echinococcus multilocularis expressed conserved protein 0.0095 0.066 0.0986
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0054 0.0322 0.2782
Brugia malayi steroid hormone receptor 0.0041 0.0219 0.025
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0416 0.3617
Mycobacterium ulcerans DNA polymerase IV 0.004 0.021 0.2322
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.054 0.4664
Schistosoma mansoni zinc finger protein 0.0019 0.0042 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0061 0.0108
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0526 0.4574
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0677 0.5887
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0054 0.0322 0.0482
Schistosoma mansoni hypothetical protein 0.0042 0.0226 0.0402
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0095 0.0822
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0219 0.0391
Brugia malayi N-terminal motif family protein 0.0184 0.138 0.1574
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0377 0.0673
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0042 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0183 0.1594
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0042 0.0062
Entamoeba histolytica hypothetical protein 0.0024 0.008 0.046
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0044 0.0381
Loa Loa (eye worm) hypothetical protein 0.0184 0.138 0.1574
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0183 0.1582
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0219 0.025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0677 0.1207
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0219 0.025
Loa Loa (eye worm) acetyltransferase 0.0152 0.1118 0.1275
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0054 0.0322 0.2803
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0183 0.0209
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0219 0.0391
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0024 0.0043
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0156 0.115 0.3716
Brugia malayi ecdysone receptor 0.0019 0.0042 0.0048
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.042 0.33 0.3761
Echinococcus granulosus expressed conserved protein 0.0095 0.066 0.1178
Loa Loa (eye worm) hypothetical protein 0.0093 0.0641 0.0731
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0219 0.0327
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0044 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0219 0.025
Brugia malayi hypothetical protein 0.0026 0.0095 0.0109
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.054 0.4664
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0219 0.025
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0183 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0677 0.0677
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1118 0.1995
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0157 0.1158 0.1731
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0365 0.0652
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.195 0.2223
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0219 0.0391
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0054 0.0322 0.2803
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0365 0.1181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0054 0.0322 0.2803
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0314 0.1015
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.195 0.2223
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0042 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0042 0.0048
Loa Loa (eye worm) hypothetical protein 0.0051 0.0299 0.0341
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0314 0.056
Schistosoma mansoni Smad4 0.0017 0.0024 0.0043
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0219 0.0391
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0184 0.138 0.138
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0238 0.0238
Echinococcus granulosus microtubule associated protein 2 0.0703 0.5605 1
Trypanosoma brucei DNA polymerase eta, putative 0.0093 0.0641 0.5575
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0526 0.4574
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0015 0.0023
Echinococcus multilocularis muscleblind protein 1 0.0297 0.2303 0.344
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0044 0.0647
Schistosoma mansoni hypothetical protein 0.0042 0.0226 0.0402
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0042 0.0075
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.021 0.1827
Brugia malayi jmjC domain containing protein 0.0061 0.0377 0.043
Echinococcus granulosus geminin 0.0177 0.1327 0.2368
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0054 0.0322 0.2782
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0024 0.0036
Brugia malayi nuclear receptor RXR 0.0022 0.0061 0.0069
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.071 0.4085
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0219 0.025
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0582 0.0663
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0095 0.0828
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0054 0.0322 0.0575
Plasmodium vivax JmjC domain containing protein 0.0016 0.0015 0.0132
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0079 0.0526 0.0938
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0079 0.0526 0.0786
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0024 0.0036
Brugia malayi RNA binding protein 0.0337 0.2625 0.2992
Schistosoma mansoni tar DNA-binding protein 0.0337 0.2625 0.4683
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0079 0.0526 0.4574
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.015 0.1104 0.1258
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0219 0.025
Brugia malayi hypothetical protein 0.0019 0.0042 0.0048
Trypanosoma brucei polo-like protein kinase 0.0097 0.0677 0.5887
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0219 0.025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0377 0.0673
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0042 0.0062
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0042 0.0048
Entamoeba histolytica hypothetical protein 0.0228 0.1739 1
Entamoeba histolytica hypothetical protein 0.0228 0.1739 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0365 0.3177
Schistosoma mansoni smad 0.0017 0.0024 0.0043
Trypanosoma brucei unspecified product 0.004 0.021 0.1827
Schistosoma mansoni alpha-glucosidase 0.0143 0.1046 0.1867
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0904 0.7867
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0333 0.0379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0219 0.025
Schistosoma mansoni DNA polymerase eta 0.0093 0.0641 0.1143
Schistosoma mansoni smad1 5 8 and 0.0017 0.0024 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0048
Echinococcus granulosus smad 0.0017 0.0024 0.0043
Brugia malayi nuclear hormone receptor 0.0019 0.0042 0.0048
Toxoplasma gondii NADPH-glutathione reductase 0.0054 0.0322 0.2782
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.025
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0042 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0219 0.025
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0054 0.0322 0.2803
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0219 0.0391
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0677 0.0677
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0677 0.0677
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0183 0.0327
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0017
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0216 0.1245
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1118 0.1275
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0054 0.0322 0.2803
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0247 0.0247
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0219 0.025

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 63 % Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex membrane at 10'-6 M by radioligand binding assay ChEMBL. 21601317
Inhibition (binding) = 91 % Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membrane at 10'-6 M by radioligand binding assay ChEMBL. 21601317
Ki (binding) = 80 nM Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membrane by radioligand binding assay ChEMBL. 21601317

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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