Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.7685 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7685 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7685 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.1453 | 0.1847 | 0.1847 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7685 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1453 | 0.1847 | 0.1847 |
Schistosoma mansoni | dihydrofolate reductase | 0.7685 | 1 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0262 | 0.0289 | 0.0289 |
Brugia malayi | RNA, U transporter 1 | 0.007 | 0.0037 | 0.0037 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4802 | 0.6228 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7685 | 1 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0262 | 0.0289 | 0.0289 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4802 | 0.6228 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1453 | 0.1847 | 0.1847 |
Echinococcus granulosus | thymidylate synthase | 0.1453 | 0.1847 | 0.1847 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4802 | 0.6228 | 1 |
Brugia malayi | hypothetical protein | 0.0691 | 0.085 | 0.085 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7685 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1453 | 0.1847 | 0.1847 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0262 | 0.0289 | 0.0289 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0589 | 0.0716 | 0.0716 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0691 | 0.085 | 0.1365 |
Loa Loa (eye worm) | thymidylate synthase | 0.1453 | 0.1847 | 0.1847 |
Onchocerca volvulus | 0.1453 | 0.1847 | 1 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4802 | 0.6228 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4802 | 0.6228 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1453 | 0.1847 | 0.1847 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.0289 | 0.0289 |
Brugia malayi | Dihydrofolate reductase | 0.7685 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7685 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0691 | 0.085 | 0.085 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0589 | 0.0716 | 0.0716 |
Brugia malayi | thymidylate synthase | 0.1453 | 0.1847 | 0.1847 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0547 | 0.0662 | 0.0662 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4802 | 0.6228 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0691 | 0.085 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.15 mM | Compound was tested for inhibition of HL60 cell adhesion to recombinant Selectin E IgG fusion protein obtained from transfected COS cells | ChEMBL. | No reference |
IC50 (functional) | = 1.5 mM | Compound was tested for inhibition of HL60 cell adhesion to recombinant P-selectin-IgG fusion protein obtained from transfected COS cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.