Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0073 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0059 | 0.7218 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0059 | 0.7218 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0.7218 | 0.7218 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0059 | 0.7218 | 0.7218 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0059 | 0.7218 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0059 | 0.7218 | 0.7218 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.7218 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0059 | 0.7218 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.7218 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0059 | 0.7218 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0059 | 0.7218 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0059 | 0.7218 | 0.7218 |
Trypanosoma brucei | protein kinase, putative | 0.0059 | 0.7218 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.7218 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0059 | 0.7218 | 0.7218 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0059 | 0.7218 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0059 | 0.7218 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.7218 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0059 | 0.7218 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0059 | 0.7218 | 0.7218 |
Brugia malayi | MAP kinase sur-1 | 0.0059 | 0.7218 | 0.7218 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.