Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | 0.1821 | 0.4544 | 0.0496 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3829 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.1821 | 0.4544 | 0.3297 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0092 | 0.0092 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3829 | 1 | 1 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0834 | 0.1859 | 0.1859 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3829 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.3829 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3829 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1821 | 0.4544 | 0.5 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0184 | 0.0092 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0092 | 0.0092 |
Onchocerca volvulus | 0.3829 | 1 | 0.5 | |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0184 | 0.0092 | 0.0092 |
Schistosoma mansoni | apoptosis regulator bax | 0.0184 | 0.0092 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0092 | 0.0092 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3829 | 1 | 0.5 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0184 | 0.0092 | 0.0092 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0184 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | thymidylate synthase | 0.3829 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0834 | 0.1859 | 0.1859 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3829 | 1 | 1 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0184 | 0.0092 | 0.0092 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3829 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.3829 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.3829 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3829 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3829 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 97 % | Inhibition of [3H]-spiperone binding to Dopamine receptor D2 of rat limbic structures | ChEMBL. | 2565399 |
Ki (binding) | = 16 nM | Compound was tested in vitro for the ability to inhibit [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and the value ranges from 12 to 20. | ChEMBL. | 2565399 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.