Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0777 | 0.0777 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0777 | 0.0777 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0158 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.2006 | 0.2006 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0158 | 0.0393 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0445 | 0.0445 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0445 | 0.7448 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0092 | 0.0092 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0158 | 0.0158 |
Echinococcus granulosus | transportin 1 | 0.0006 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0345 | 1 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0777 | 0.4231 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0525 | 0.0512 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0158 | 0.0158 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0092 | 0.0092 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0092 | 0.0092 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0092 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0158 | 0.0158 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0525 | 0.6744 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0445 | 0.0445 |
Loa Loa (eye worm) | kap beta 3 protein | 0.0006 | 0.0004 | 0.0004 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0158 | 0.0393 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.2006 | 0.2006 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0158 | 0.0158 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0158 | 0.0393 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.1831 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0158 | 0.0393 |
Echinococcus granulosus | importin 5 | 0.0006 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1831 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0158 | 0.0393 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0092 | 0.023 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0777 | 0.0777 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0158 | 0.0393 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0158 | 0.0158 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0445 | 0.5711 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0158 | 0.0158 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0158 | 0.0393 |
Schistosoma mansoni | ran | 0.0024 | 0.0525 | 0.0525 |
Loa Loa (eye worm) | importin-beta domain-containing protein | 0.0006 | 0.0004 | 0.0004 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0142 | 0.4012 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0158 | 0.0158 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0158 | 0.0158 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.2006 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0596 | 0.296 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0777 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.1831 | 0.1831 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0777 | 0.3861 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0596 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0158 | 0.0393 |
Onchocerca volvulus | 0.0011 | 0.0158 | 0.5 | |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0445 | 0.2205 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0158 | 0.0393 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0158 | 0.0158 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1831 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0445 | 0.2205 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0158 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0158 | 0.0158 |
Echinococcus granulosus | smad | 0.0009 | 0.0092 | 0.0092 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0596 | 0.296 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0158 | 0.0158 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0092 | 0.0092 |
Echinococcus granulosus | tar DNA binding protein | 0.0142 | 0.4012 | 0.4012 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.1831 | 0.1831 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0092 | 0.0092 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0158 | 0.0158 |
Echinococcus multilocularis | importin 5 | 0.0006 | 0.0004 | 0.0004 |
Echinococcus multilocularis | transportin 1 | 0.0006 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0158 | 0.0158 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0158 | 0.0158 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0158 | 0.0158 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0445 | 0.2205 |
Schistosoma mansoni | smad | 0.0009 | 0.0092 | 0.0092 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0158 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0158 | 0.0158 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0158 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0158 | 0.0158 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0158 | 0.0393 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0158 | 0.0158 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0777 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.1831 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0158 | 0.0393 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0445 | 0.2416 |
Brugia malayi | kap beta 3 protein | 0.0006 | 0.0004 | 0.0009 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0525 | 0.0525 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0158 | 0.0158 |
Echinococcus multilocularis | snurportin 1 | 0.0345 | 1 | 1 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0024 | 0.0525 | 0.2853 |
Echinococcus multilocularis | smad | 0.0009 | 0.0092 | 0.0092 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.377 | 0.9398 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0092 | 0.0092 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0525 | 0.2604 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.377 | 0.377 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0445 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.1831 | 0.1831 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0525 | 0.0512 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4012 | 0.4012 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0158 | 0.0158 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.2006 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0445 | 0.0445 |
Brugia malayi | TAR-binding protein | 0.0142 | 0.4012 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0142 | 0.4012 | 0.4012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0158 | 0.0158 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0158 | 0.0393 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0158 | 0.0393 |
Entamoeba histolytica | Ran family GTPase | 0.0024 | 0.0525 | 0.2604 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0158 | 0.0158 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4012 | 0.4012 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0158 | 0.0158 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0596 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1831 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0596 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0158 | 0.0158 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0777 | 0.0777 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0043 | 0.1087 | 0.1087 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4012 | 0.4012 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0092 | 0.0092 |
Echinococcus granulosus | translational activator gcn1 | 0.0006 | 0.0004 | 0.0004 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0777 | 0.1936 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | TAR-binding protein | 0.0142 | 0.4012 | 0.4012 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0445 | 0.7448 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0158 | 0.0158 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0043 | 0.1087 | 0.1087 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0158 | 0.0158 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0158 | 0.0158 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0092 | 0.0092 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0158 | 0.0158 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.2006 | 0.2006 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.1831 | 0.9126 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0024 | 0.0525 | 0.0525 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0158 | 0.0158 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0092 | 0.023 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0024 | 0.0525 | 0.6744 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0777 | 0.3861 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0092 | 0.0092 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0445 | 0.5711 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0024 | 0.0525 | 0.0525 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0074 | 0.2006 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0092 | 0.0092 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0596 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0158 | 0.0158 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0445 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.377 | 0.377 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4012 | 0.4012 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0092 | 0.0092 |
Schistosoma mansoni | ran | 0.0024 | 0.0525 | 0.0525 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0158 | 0.0158 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0158 | 0.0158 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0445 | 0.0445 |
Trichomonas vaginalis | ran, putative | 0.0024 | 0.0525 | 0.8795 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0158 | 0.0158 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0092 | 0.023 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0445 | 0.0445 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0158 | 0.0158 |
Echinococcus multilocularis | translational activator gcn1 | 0.0006 | 0.0004 | 0.0004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4012 | 0.4012 |
Brugia malayi | RNA binding protein | 0.0142 | 0.4012 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0142 | 0.4012 | 0.4012 |
Echinococcus multilocularis | tar DNA binding protein | 0.0142 | 0.4012 | 0.4012 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0092 | 0.0092 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0158 | 0.0393 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0158 | 0.0393 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0158 | 0.0158 |
Brugia malayi | RNA, U transporter 1 | 0.0092 | 0.2534 | 0.6317 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0158 | 0.0158 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0525 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0158 | 0.0158 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0158 | 0.0158 |
Schistosoma mansoni | importin-beta 2 | 0.0006 | 0.0004 | 0.0004 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0445 | 0.111 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0074 | 0.2006 | 1 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0092 | 0.0092 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0158 | 0.0393 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.2006 | 1 |
Brugia malayi | Smad1 | 0.0009 | 0.0092 | 0.023 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0525 | 0.1309 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0158 | 0.0393 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.2006 | 0.2006 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.1831 | 0.1831 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0158 | 0.0393 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0158 | 0.0393 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0158 | 0.0158 |
Leishmania major | GTP-binding protein, putative | 0.0024 | 0.0525 | 0.2604 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0158 | 0.0158 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0074 | 0.2006 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.