Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0071 | 0.6833 | 0.6823 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0026 | 0.2216 | 0.2191 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0091 | 0.889 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.006 | 0.5684 | 0.567 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.889 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0091 | 0.889 | 0.8886 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0359 | 0.1619 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0102 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.1302 | 0.1274 |
Brugia malayi | Probable ClpP-like protease | 0.0091 | 0.889 | 0.8886 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0026 | 0.2216 | 0.2191 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0.279 | 0.1961 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0026 | 0.2216 | 0.2191 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.1302 | 0.1274 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0359 | 0.1619 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0031 | 0.279 | 0.1961 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0102 | 1 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0359 | 0.1619 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.3002 | 0.2979 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0433 | 0.0403 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0026 | 0.2216 | 1 |
Trichomonas vaginalis | GTP-binding protein (q) alpha-11 subunit, gna11, putative | 0.0004 | 0.0032 | 0.0144 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0359 | 0.1619 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.889 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0433 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.889 | 0.8886 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3496 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.1302 | 0.1274 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0359 | 0.1619 |
Trichomonas vaginalis | GTP-binding protein (O) alpha subunit, gnao, putative | 0.0004 | 0.0032 | 0.0144 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.889 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3496 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.3197 | 0.3175 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.3496 | 0.3475 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.889 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0091 | 0.889 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.6059 | 0.6269 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0642 | 0.0612 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0642 | 0.0612 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0026 | 0.2216 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0642 | 0.0612 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0026 | 0.2216 | 0.1205 |
Trichomonas vaginalis | chaperonin, putative | 0.0026 | 0.2216 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.3002 | 0.2979 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.006 | 0.5684 | 0.4744 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.3197 | 0.3175 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0359 | 0.1619 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.889 | 0.5 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0628 | 0.0598 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0091 | 0.889 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0091 | 0.889 | 0.8886 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0359 | 0.1619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0359 | 0.1619 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.1302 | 0.1274 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0026 | 0.2216 | 0.1205 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.3496 | 0.3475 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0026 | 0.2216 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.1302 | 0.1274 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0026 | 0.2216 | 0.1205 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.889 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0102 | 1 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0026 | 0.2216 | 0.2191 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0026 | 0.2216 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.1302 | 0.1274 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.3197 | 0.3175 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0359 | 0.1619 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0359 | 0.1619 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.1302 | 0.1274 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0433 | 0.0403 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.3197 | 0.3175 |
Echinococcus granulosus | peptidase Clp S14 family | 0.006 | 0.5684 | 0.567 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0026 | 0.2216 | 0.2191 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0359 | 0.1619 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0359 | 0.1619 |
Trichomonas vaginalis | GTP-binding protein (z) alpha subunit, gnaz, putative | 0.0004 | 0.0032 | 0.0144 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3496 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0359 | 0.1619 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0091 | 0.889 | 0.8886 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.3002 | 0.2979 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.006 | 0.5684 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0359 | 0.1619 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0004 | 0.0032 | 0.0144 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0102 | 1 | 1 |
Trichomonas vaginalis | G protein (olf) alpha subunit, gnal, putative | 0.0004 | 0.0032 | 0.0144 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0031 | 0.279 | 0.1961 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0026 | 0.2216 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.1302 | 0.1274 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0026 | 0.2216 | 0.6306 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.006 | 0.5684 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.3496 | 0.3475 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0359 | 0.1619 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0004 | 0.0032 | 0.0144 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.1302 | 0.1274 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0359 | 0.1619 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.889 | 0.5 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0004 | 0.0032 | 0.0144 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0433 | 0.0403 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0026 | 0.2216 | 0.2191 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.1302 | 0.1274 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0075 | 0.0043 |
Onchocerca volvulus | 0.0033 | 0.3002 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.3496 | 0.3475 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3496 | 1 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0004 | 0.0032 | 0.0144 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0359 | 0.1619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0359 | 0.1619 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0433 | 0.0403 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0102 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.3496 | 0.3475 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0026 | 0.2216 | 0.2191 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0091 | 0.889 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0026 | 0.2216 | 0.2191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.