Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.034 | 0.0035 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0125 | 0.6906 | 0.8837 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0125 | 0.6906 | 0.8749 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0125 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0125 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0139 | 0.7773 | 1 |
Brugia malayi | glutathione reductase | 0.0055 | 0.254 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0841 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0409 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0019 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0125 | 0.6906 | 0.8837 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0841 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0841 | 0.0707 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0841 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.254 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0841 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.0841 | 0.5 | |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0139 | 0.7773 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.254 | 1 |
Treponema pallidum | NADH oxidase | 0.0019 | 0.0313 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.254 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0055 | 0.254 | 0.2985 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.034 | 0.0035 |
Leishmania major | trypanothione reductase | 0.0055 | 0.254 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0841 | 0.2027 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0021 | 0.0409 | 0.1815 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0313 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0841 | 0.3311 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0139 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.034 | 0.0035 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0841 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0841 | 0.3311 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0409 | 0.043 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0125 | 0.6906 | 0.8837 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0019 | 0.0313 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0841 | 0.237 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0841 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0841 | 0.237 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0841 | 0.2027 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0139 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0125 | 0.6906 | 0.8837 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.254 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.254 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.254 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.254 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0019 | 0.0313 | 0.1234 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0841 | 0.0707 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0841 | 0.237 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.254 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0019 | 0.0313 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.254 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.0841 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.034 | 0.0035 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0841 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.254 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0409 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0841 | 0.2027 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0313 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0841 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.254 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.254 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0841 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0841 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0409 | 0.0128 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0841 | 0.3311 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 72 mg kg-1 | Analgesic activity in sc dosed ddY mouse assessed as inhibition of acetic acid-induced abdominal stretching pretreated for 30 mins followed by acetic acid challenge measured for 5 to 20 mins | ChEMBL. | 311385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.