Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0107 | 0.4707 | 0.2339 |
Brugia malayi | Trypsin family protein | 0.011 | 0.4885 | 1 |
Loa Loa (eye worm) | peptidase family M48 containing protein | 0.0079 | 0.3091 | 0.5616 |
Trichomonas vaginalis | Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase | 0.0079 | 0.3091 | 0.6566 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Toxoplasma gondii | CAAX metallo endopeptidase | 0.0079 | 0.3091 | 0.5 |
Echinococcus multilocularis | geminin | 0.0198 | 1 | 1 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0107 | 0.4707 | 1 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0107 | 0.4707 | 0.2339 |
Giardia lamblia | Hypothetical protein | 0.0107 | 0.4707 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4885 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.1866 | 0.2622 |
Brugia malayi | Peptidase family M48 containing protein | 0.0079 | 0.3091 | 0.5616 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.011 | 0.4885 | 0.4444 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0107 | 0.4707 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4885 | 1 |
Schistosoma mansoni | farnesylated-protein converting enzyme 1 (M48 family) | 0.0079 | 0.3091 | 0.2496 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0107 | 0.4707 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0107 | 0.4707 | 0.4251 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0107 | 0.4707 | 1 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0107 | 0.4707 | 1 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0107 | 0.4707 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.1866 | 0.2622 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0107 | 0.4707 | 0.9567 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Onchocerca volvulus | 0.011 | 0.4885 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.1866 | 0.2622 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0107 | 0.4707 | 0.4251 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.4707 | 0.9567 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1866 | 0.2622 |
Trichomonas vaginalis | Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase | 0.0079 | 0.3091 | 0.6566 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.011 | 0.4885 | 0.4444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.