Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 24 nM | Agonistic activity against human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand | ChEMBL. | 10612602 |
EC50 (functional) | = 24 nM | Agonistic activity against human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand | ChEMBL. | 10612602 |
EC50 (functional) | = 58.42 nM | Agonistic activity against human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand | ChEMBL. | 10612602 |
EC50 (functional) | = 58.42 nM | Agonistic activity against human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand | ChEMBL. | 10612602 |
EC50 (functional) | = 1421 nM | Agonistic activity against human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand | ChEMBL. | 10612602 |
EC50 (functional) | = 1421 nM | Agonistic activity against human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand | ChEMBL. | 10612602 |
Ki (binding) | = 6.48 nM | Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand. | ChEMBL. | 10612602 |
Ki (binding) | = 6.48 nM | Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand. | ChEMBL. | 10612602 |
Ki (binding) | = 7.34 nM | Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand | ChEMBL. | 10612602 |
Ki (binding) | = 7.34 nM | Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand | ChEMBL. | 10612602 |
Ki (binding) | = 45.014 nM | Binding affinity towards human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand. | ChEMBL. | 10612602 |
Ki (binding) | = 45.014 nM | Binding affinity towards human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand. | ChEMBL. | 10612602 |
Stimulation (functional) | = 49.45 % | Agonistic activity against human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand | ChEMBL. | 10612602 |
Stimulation (functional) | = 49.45 % | Agonistic activity against human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand | ChEMBL. | 10612602 |
Stimulation (functional) | = 89.4 % | Agonistic activity against human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand | ChEMBL. | 10612602 |
Stimulation (functional) | = 89.4 % | Agonistic activity against human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligand | ChEMBL. | 10612602 |
Stimulation (functional) | = 92.5 % | Agonistic activity against human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand | ChEMBL. | 10612602 |
Stimulation (functional) | = 92.5 % | Agonistic activity against human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand | ChEMBL. | 10612602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.