Detailed information for compound 1864934

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.359 | Formula: C19H19NO3
  • H donors: 3 H acceptors: 3 LogP: 0.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCNCC(c1cc2ccccc2c2c1cccc2)O
  • InChi: 1S/C19H19NO3/c21-18(12-20-10-9-19(22)23)17-11-13-5-1-2-6-14(13)15-7-3-4-8-16(15)17/h1-8,11,18,20-21H,9-10,12H2,(H,22,23)
  • InChiKey: PRULHGWLHMKJHF-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0025 0.0909 0.0945
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.291 0.2929
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.1998 0.1736
Brugia malayi Variant SH3 domain containing protein 0.0014 0.036 0.031
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.1998 0.4562
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Brugia malayi hypothetical protein 0.0029 0.1102 0.1169
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.4334 0.8837
Echinococcus multilocularis aldo keto reductase 0.0072 0.3364 0.3401
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Loa Loa (eye worm) oxidoreductase 0.0072 0.3364 0.3784
Echinococcus granulosus tyrosine protein kinase Blk 0.0025 0.0924 0.0865
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.3017 0.7328
Echinococcus granulosus aldo keto reductase 0.0072 0.3364 0.3401
Entamoeba histolytica protein kinase, putative 0.0018 0.0538 0.1146
Loa Loa (eye worm) TK protein kinase 0.0025 0.0924 0.0962
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0025 0.0924 0.0865
Brugia malayi SRC-1 0.0032 0.13 0.1397
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0468 0.0391
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0032 0.13 0.1256
Brugia malayi Pre-SET motif family protein 0.0025 0.0909 0.0945
Leishmania major trypanothione reductase 0.0039 0.1674 0.3151
Echinococcus granulosus growth factor receptor bound protein 2 0.0014 0.036 0.0278
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.6913 0.7093
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.4002 1
Echinococcus multilocularis aldehyde reductase 0.0051 0.2273 0.2267
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.3364 0.3401
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.1998 0.1982
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.13 0.1256
Entamoeba histolytica aldose reductase, putative 0.0072 0.3364 0.7269
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.6913 0.709
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.776 0.7973
Trichomonas vaginalis aldo/keto reductase, putative 0.0072 0.3364 0.3146
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.2484 0.4767
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.1674 0.1645
Leishmania major prostaglandin f synthase, putative 0.0072 0.3364 0.7074
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.1798 0.4861
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0481 0.0405
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.002 0.0661 0.0591
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.1674 0.3151
Loa Loa (eye worm) hypothetical protein 0.0095 0.4598 0.5212
Echinococcus multilocularis tyrosine protein kinase Blk 0.0025 0.0924 0.0865
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.002 0.0661 0.0601
Echinococcus granulosus tyrosine protein kinase Fyn 0.0032 0.13 0.1256
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0317 0.0261
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0273 0.0188
Onchocerca volvulus 0.0009 0.0092 0.0092
Trypanosoma brucei prostaglandin f synthase 0.0072 0.3364 0.7074
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.4624 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.6913 0.7889
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.3364 0.3401
Loa Loa (eye worm) hypothetical protein 0.0017 0.0481 0.045
Trichomonas vaginalis set domain proteins, putative 0.0198 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0032 0.13 0.1256
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.291 0.2936
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.4002 0.407
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0072 0.3364 0.3784
Plasmodium falciparum glutathione reductase 0.0039 0.1674 0.3683
Echinococcus multilocularis aldo keto reductase 0.0072 0.3364 0.3401
Plasmodium vivax glutathione reductase, putative 0.0039 0.1674 0.3683
Loa Loa (eye worm) oxidoreductase 0.0072 0.3364 0.3784
Schistosoma mansoni adapter molecule crk 0.0014 0.036 0.0288
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.4334 0.8734
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0032 0.13 0.1256
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0909 0.0858
Echinococcus granulosus aldo keto reductase 0.0072 0.3364 0.3401
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0689 0.0383
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.4863 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0021 0.0689 0.1472
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.3364 0.3401
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.1115 0.2165
Plasmodium vivax SET domain protein, putative 0.0025 0.0909 0.1605
Onchocerca volvulus 0.0009 0.0092 0.0092
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.3017 0.3048
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0025 0.0924 0.0865
Onchocerca volvulus 0.0009 0.0092 0.0092
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0481 0.0444
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0032 0.13 0.1256
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0072 0.3364 0.3784
Echinococcus granulosus tyrosine protein kinase Fyn 0.0032 0.13 0.1256
Leishmania major hypothetical protein, conserved 0.0017 0.0481 0.038
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0481 0.038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0025 0.0909 0.0849
Brugia malayi glutathione reductase 0.0039 0.1674 0.183
Echinococcus multilocularis voltage gated potassium channel subunit 0.0021 0.0689 0.062
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.3364 0.3401
Trypanosoma cruzi aldo/keto reductase, putative 0.0021 0.0689 0.0862
Brugia malayi Thioredoxin reductase 0.0039 0.1674 0.183
Giardia lamblia Aldose reductase 0.0072 0.3364 1
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0481 0.0405
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0032 0.13 0.1256
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.776 0.8869
Mycobacterium tuberculosis Probable reductase 0.009 0.4334 0.8837
Trichomonas vaginalis aldo-keto reductase, putative 0.0021 0.0689 0.0383
Brugia malayi NADH-dependent xylose reductase 0.0021 0.0689 0.069
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0481 0.038
Echinococcus multilocularis aldo keto reductase 0.0072 0.3364 0.3401
Brugia malayi Protein kinase domain containing protein 0.0096 0.4624 0.5242
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.002 0.0661 0.0798
Echinococcus granulosus aldo keto reductase 0.0072 0.3364 0.3401
Brugia malayi T-complex protein 1, beta subunit 0.002 0.0661 0.0658
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.1102 0.213
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0481 0.038
Schistosoma mansoni tyrosine kinase 0.0032 0.13 0.1265
Leishmania major hypothetical protein, conserved 0.0029 0.1102 0.1823
Echinococcus multilocularis growth factor receptor bound protein 2 0.0014 0.036 0.0278
Loa Loa (eye worm) TK protein kinase 0.0018 0.0538 0.0516
Onchocerca volvulus 0.0009 0.0092 0.0092
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.1115 0.2165
Trypanosoma brucei aldo/keto reductase, putative 0.0021 0.0689 0.0862
Entamoeba histolytica hypothetical protein 0.0096 0.4624 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0009 0.0092 0.0178
Loa Loa (eye worm) hypothetical protein 0.0084 0.4002 0.4522
Plasmodium vivax aldehyde reductase, putative 0.0021 0.0689 0.1008
Schistosoma mansoni tyrosine kinase 0.0009 0.0092 0.001
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.4002 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0021 0.0689 0.1008
Plasmodium falciparum aldo-keto reductase, putative 0.0021 0.0689 0.1008
Schistosoma mansoni hypothetical protein 0.0192 0.9712 1
Schistosoma mansoni tyrosine kinase 0.0032 0.13 0.1265
Echinococcus multilocularis dual specificity 0.0096 0.4624 0.4711
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0481 0.045
Onchocerca volvulus 0.0021 0.0689 0.0689
Echinococcus multilocularis NCK adaptor protein 0.0014 0.036 0.0278
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0072 0.3364 0.3146
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.3017 0.6269
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0481 0.0414
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.4334 0.8837
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0481 0.0405
Loa Loa (eye worm) acetyltransferase 0.0155 0.776 0.8869
Entamoeba histolytica protein kinase, putative 0.0096 0.4624 1
Giardia lamblia Aldose reductase 0.0072 0.3364 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0032 0.13 0.1256
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0273 0.0188
Trichomonas vaginalis aldo/keto reductase, putative 0.0072 0.3364 0.3146
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0032 0.13 0.1256
Onchocerca volvulus 0.0009 0.0092 0.0092
Echinococcus multilocularis tyrosine protein kinase shark 0.0009 0.0092 0.000000057079
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0481 0.045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.3364 0.3401
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0021 0.0689 0.0383
Schistosoma mansoni aldo-keto reductase 0.0072 0.3364 0.3408
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.002 0.0661 0.0601
Echinococcus granulosus tyrosine kinase 0.0025 0.0924 0.0865
Schistosoma mansoni hypothetical protein 0.0192 0.9712 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.4002 0.4064
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0317 0.0244
Trypanosoma brucei trypanothione reductase 0.0039 0.1674 0.3151
Echinococcus granulosus tyrosine protein kinase Src64B 0.0032 0.13 0.1256
Schistosoma mansoni aldo-keto reductase 0.0072 0.3364 0.3408
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0072 0.3364 0.3146
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.1102 0.1823
Brugia malayi jmjC domain containing protein 0.0017 0.0481 0.045
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0481 0.0414
Brugia malayi Pre-SET motif family protein 0.0174 0.8737 1
Toxoplasma gondii hypothetical protein 0.0029 0.1115 0.2165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.6913 0.709
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.1998 0.4562
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.1102 0.1823
Brugia malayi Variant SH3 domain containing protein 0.0014 0.036 0.031
Giardia lamblia TCP-1 chaperonin subunit beta 0.002 0.0661 0.1128
Mycobacterium leprae Conserved hypothetical protein 0.0051 0.2273 0.3795
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.002 0.0661 0.0932
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.4002 0.7937
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.4002 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.1674 0.2985
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.036 0.0288
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0021 0.0689 0.069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.6913 0.709
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0072 0.3364 0.3784
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.4334 0.8837
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0861 0.0799
Loa Loa (eye worm) oxidoreductase 0.0072 0.3364 0.3784
Onchocerca volvulus 0.0072 0.3364 0.3364
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0481 0.0444
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.6913 0.7889
Loa Loa (eye worm) oxidoreductase 0.0072 0.3364 0.3784
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0072 0.3364 0.7074
Trypanosoma brucei aldo-keto reductase, putative 0.0072 0.3364 0.7074
Schistosoma mansoni nck2/grb4 0.0014 0.036 0.0288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0481 0.045
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.4002 1
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.002 0.0661 0.0798
Schistosoma mansoni jumonji domain containing protein 0.0063 0.291 0.2936
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0468 0.0391
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0909 0.0858
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0032 0.13 0.1256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.6913 0.709
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.291 0.2929
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.4624 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0021 0.0689 0.0383
Brugia malayi protein-tyrosine kinase 0.0025 0.0924 0.0962
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Toxoplasma gondii aldo-keto reductase 0.0021 0.0689 0.1008
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.4624 0.4716
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0021 0.0689 0.069
Mycobacterium ulcerans oxidoreductase 0.0072 0.3364 0.8268
Onchocerca volvulus 0.0072 0.3364 0.3364
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.3017 0.3041
Echinococcus granulosus dual specificity 0.0096 0.4624 0.4711
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0072 0.3364 0.7074
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0481 0.0405
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.4334 0.8837
Trichomonas vaginalis aldo-keto reductase, putative 0.0021 0.0689 0.0383
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.4002 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0317 0.0234
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.4002 1
Mycobacterium ulcerans hypothetical protein 0.0021 0.0689 0.1008
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.3017 0.3041
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0021 0.0689 0.1008
Echinococcus granulosus NCK adaptor protein 0.0014 0.036 0.0278
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Plasmodium vivax JmjC domain containing protein 0.0017 0.0481 0.0444
Loa Loa (eye worm) glutathione reductase 0.0039 0.1674 0.183
Loa Loa (eye worm) SRC-1 0.0032 0.13 0.1397
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0021 0.0689 0.062
Leishmania major aldo-keto reductase-like protein 0.0072 0.3364 0.7074
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.1102 0.213
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.3017 0.5939
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.291 0.2936
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0126 0.004
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0032 0.13 0.1256
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0481 0.045
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0481 0.0414
Toxoplasma gondii aldose reductase, putative 0.0072 0.3364 0.8268
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.776 0.7971
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.1102 0.213
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0481 0.0405
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0126 0.004
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.002 0.0661 0.1412
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0174 0.8737 1
Echinococcus granulosus geminin 0.0192 0.9712 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.1115 0.2165
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.4624 1
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.036 0.0288
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0468 0.0391
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0072 0.3364 0.6408
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.4002 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0021 0.0689 0.0862
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.3017 0.7328
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.4002 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0317 0.0234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0909 0.0858
Echinococcus granulosus tyrosine protein kinase shark 0.0009 0.0092 0.000000057079
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.3364 0.3401
Brugia malayi T-complex protein 1, beta subunit 0.002 0.0661 0.0658
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.6913 0.7093
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.13 0.1256
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.4863 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.3364 0.3401
Mycobacterium tuberculosis Conserved protein 0.0021 0.0689 0.0817
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0072 0.3364 0.3146
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.4863 1
Onchocerca volvulus 0.0072 0.3364 0.3364
Echinococcus granulosus aldehyde reductase 0.0051 0.2273 0.2267
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0032 0.13 0.1256
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0481 0.0414
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0014 0.036 0.031
Echinococcus granulosus tyrosine protein kinase Src42A 0.0023 0.0816 0.0752
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.1798 0.4019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.3017 0.7328
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0481 0.0405
Schistosoma mansoni tyrosine kinase 0.0009 0.0092 0.001
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0468 0.0391
Echinococcus granulosus tyrosine protein kinase HCK 0.0018 0.0538 0.0464
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0481 0.0414
Loa Loa (eye worm) hypothetical protein 0.0095 0.4598 0.5212
Brugia malayi hypothetical protein 0.0018 0.0569 0.0552
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.4624 1
Schistosoma mansoni hypothetical protein 0.0013 0.0273 0.0198
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.291 0.2929
Brugia malayi jmjC domain containing protein 0.0063 0.291 0.3259
Loa Loa (eye worm) hypothetical protein 0.0029 0.1102 0.1169
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.1674 0.1645
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.1998 0.4562
Echinococcus granulosus phd:f box containing protein 0.0017 0.0481 0.0405
Onchocerca volvulus 0.0072 0.3364 0.3364
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0023 0.0816 0.0752
Entamoeba histolytica alcohol dehydrogenase, putative 0.0021 0.0689 0.1472
Echinococcus multilocularis geminin 0.0192 0.9712 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0072 0.3364 0.3146
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0481 0.0405
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0032 0.13 0.1256
Brugia malayi jmjC domain containing protein 0.0017 0.0481 0.045
Onchocerca volvulus 0.0025 0.0909 0.0909
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.6913 0.7093
Echinococcus multilocularis tyrosine protein kinase HCK 0.0018 0.0538 0.0464
Mycobacterium tuberculosis Probable oxidoreductase 0.0072 0.3364 0.6701
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.2484 0.2487
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0014 0.036 0.031
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0468 0.0391
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.4002 1
Onchocerca volvulus 0.0072 0.3364 0.3364
Loa Loa (eye worm) hypothetical protein 0.0072 0.3364 0.3784
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.4002 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.3364 0.3401
Plasmodium falciparum thioredoxin reductase 0.0039 0.1674 0.3683
Brugia malayi jmjC domain containing protein 0.0017 0.0481 0.045
Brugia malayi jmjC domain containing protein 0.0063 0.291 0.3259
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0481 0.0405
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.2484 0.2487
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.2484 0.4767
Loa Loa (eye worm) T-complex protein 1 0.002 0.0661 0.0658
Onchocerca volvulus 0.0009 0.0092 0.0092
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.3017 0.3048
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.4624 0.5242
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0014 0.036 0.0288
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Echinococcus granulosus hypothetical protein 0.0072 0.3364 0.3401
Schistosoma mansoni tyrosine kinase 0.0017 0.0468 0.0401
Schistosoma mansoni potassium channel beta 0.0021 0.0689 0.063
Onchocerca volvulus 0.0072 0.3364 0.3364
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.4002 0.4064
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.7531 0.7733
Loa Loa (eye worm) hypothetical protein 0.0017 0.0481 0.045
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.4624 1
Plasmodium falciparum aldehyde reductase, putative 0.0021 0.0689 0.1008
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.4863 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Trypanosoma cruzi aldo-keto reductase 0.0072 0.3364 0.7074
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.1102 0.213
Leishmania major T-complex protein 1, beta subunit, putative 0.002 0.0661 0.0798
Loa Loa (eye worm) oxidoreductase 0.0072 0.3364 0.3784
Schistosoma mansoni pol-related 0.0072 0.3364 0.3408
Entamoeba histolytica protein kinase, putative 0.0096 0.4624 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0468 0.0435
Brugia malayi Sex muscle abnormal protein 5 0.0014 0.036 0.031
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.1674 0.183
Echinococcus multilocularis aldo keto reductase 0.0072 0.3364 0.3401
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.002 0.0661 0.0601
Toxoplasma gondii t-complex protein beta subunit 0.002 0.0661 0.0932
Echinococcus multilocularis tyrosine protein kinase Srms 0.0025 0.0924 0.0865
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.4334 0.8837
Entamoeba histolytica aldose reductase, putative 0.0072 0.3364 0.7269
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.002 0.0661 0.0355
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.1998 0.1736
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.3017 0.7328
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.3364 0.3146
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0025 0.0909 0.1605
Brugia malayi Probable ClpP-like protease 0.0084 0.4002 0.4522
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.002 0.0661 0.0591
Brugia malayi jmjC domain containing protein 0.0017 0.0481 0.045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0025 0.0909 0.0858
Trypanosoma cruzi aldo/keto reductase, putative 0.0072 0.3364 0.7074
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.1798 0.3876
Plasmodium falciparum T-complex protein 1 subunit beta 0.002 0.0661 0.0932
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.291 0.2929
Toxoplasma gondii thioredoxin reductase 0.0039 0.1674 0.3683
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.1115 0.1022
Loa Loa (eye worm) hypothetical protein 0.0014 0.036 0.031
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.1102 0.1823
Trichomonas vaginalis chaperonin, putative 0.002 0.0661 0.0355
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0468 0.0401
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.3364 0.3401
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0072 0.3364 0.3784
Echinococcus granulosus voltage gated potassium channel subunit 0.0021 0.0689 0.062
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0481 0.0444
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.1674 0.3683
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0025 0.0909 0.0849
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0021 0.0689 0.1008
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0481 0.0405
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.291 0.3259
Echinococcus granulosus tyrosine protein kinase Lyn 0.0033 0.1326 0.1283
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.3364 0.3401
Entamoeba histolytica aldose reductase, putative 0.0072 0.3364 0.7269
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.2484 0.4302
Schistosoma mansoni tyrosine kinase 0.0017 0.0468 0.0401
Echinococcus granulosus histone lysine methyltransferase setb 0.0025 0.0909 0.0849

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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