Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma japonicum | ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma mansoni | retinoic acid receptor RXR | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, gamma | 340 aa | 338 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0034 | 0.0022 | 0.0022 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0034 | 0.0022 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0034 | 0.0022 | 0.0022 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0034 | 0.0022 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0034 | 0.0022 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0034 | 0.0022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 0.0022 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0034 | 0.0022 | 0.0022 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0452 | 0.9595 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0034 | 0.0022 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0034 | 0.0022 | 0.0022 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 0.0022 | 0.0022 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0034 | 0.0022 | 0.0022 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0034 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0022 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0034 | 0.0022 | 0.0022 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0034 | 0.0022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0034 | 0.0022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0022 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0034 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 0.0022 | 1 |
Brugia malayi | steroid hormone receptor | 0.0034 | 0.0022 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0034 | 0.0022 | 0.0022 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0034 | 0.0022 | 0.0022 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 0.0022 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0022 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0034 | 0.0022 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0034 | 0.0022 | 0.0022 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0034 | 0.0022 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0034 | 0.0022 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.047 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0034 | 0.0022 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 0.0022 | 0.0022 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0034 | 0.0022 | 0.0022 |
Schistosoma mansoni | thyroid hormone receptor | 0.0034 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0034 | 0.0022 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 0.0022 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0034 | 0.0022 | 0.0022 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 0.0022 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0034 | 0.0022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0034 | 0.0022 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0034 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0034 | 0.0022 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0034 | 0.0022 | 0.0022 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0022 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 0.0022 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0034 | 0.0022 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0034 | 0.0022 | 0.0022 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0034 | 0.0022 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0034 | 0.0022 | 0.0022 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0034 | 0.0022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0034 | 0.0022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0022 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0034 | 0.0022 | 0.0022 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0034 | 0.0022 | 0.0022 |
Brugia malayi | nuclear hormone receptor | 0.0034 | 0.0022 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0034 | 0.0022 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0034 | 0.0022 | 0.0022 |
Echinococcus granulosus | FTZ F1 alpha | 0.0034 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0022 | 1 |
Onchocerca volvulus | 0.0034 | 0.0022 | 1 | |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0034 | 0.0022 | 0.0022 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0034 | 0.0022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0022 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0034 | 0.0022 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0034 | 0.0022 | 0.0022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 3 % | Relative activity against Retinoic acid receptor alpha at 10e-6 M with respect to 10e-6 M of trans-RA | ChEMBL. | 7650690 |
Activity (binding) | = 3 % | Relative activity against Retinoic acid receptor alpha at 10e-6 M with respect to 10e-6 M of trans-RA | ChEMBL. | 7650690 |
Activity (binding) | = 22 % | Relative activity against Retinoic acid receptor gamma at 10e-6 M with respect to 10e-6 M of trans-RA | ChEMBL. | 7650690 |
Activity (binding) | = 22 % | Relative activity against Retinoic acid receptor gamma at 10e-6 M with respect to 10e-6 M of trans-RA | ChEMBL. | 7650690 |
Activity (binding) | = 52 % | Relative activity against Retinoic acid receptor RXR-alpha at 10e-6 M retinoid relative to 10e-6 M of 9-cis-RA. | ChEMBL. | 7650690 |
Activity (binding) | = 52 % | Relative activity against Retinoic acid receptor RXR-alpha at 10e-6 M retinoid relative to 10e-6 M of 9-cis-RA. | ChEMBL. | 7650690 |
Activity (binding) | = 74 % | Relative activity against Retinoic acid receptor beta at 10e-6 M with respect to 10e-6 M of trans-RA | ChEMBL. | 7650690 |
Activity (binding) | = 74 % | Relative activity against Retinoic acid receptor beta at 10e-6 M with respect to 10e-6 M of trans-RA | ChEMBL. | 7650690 |
EC50 (binding) | = 33 nM | Effective concentrations against Retinoic acid receptor RXR-beta | ChEMBL. | 7650690 |
EC50 (binding) | = 33 nM | Effective concentrations against Retinoic acid receptor RXR-beta | ChEMBL. | 7650690 |
EC50 (binding) | = 330 nM | Effective concentration against Retinoic acid receptor RXR-alpha | ChEMBL. | 7650690 |
EC50 (binding) | = 330 nM | Effective concentration against Retinoic acid receptor RXR-alpha | ChEMBL. | 7650690 |
EC50 (binding) | = 520 nM | Effective concentrations against Retinoic acid receptor RXR-gamma | ChEMBL. | 7650690 |
EC50 (binding) | = 520 nM | Effective concentrations against Retinoic acid receptor RXR-gamma | ChEMBL. | 7650690 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.