Detailed information for compound 186661

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 623.776 | Formula: C36H49NO8
  • H donors: 0 H acceptors: 5 LogP: 6.58 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CC[C@@H]1/C=C(\C)/C[C@H](C)C(=O)OCC(C)(C)C(=O)C(=O)N2[C@H](C(=O)O[C@@H]([C@@H](COC1=O)C)CCc1ccccc1)CCCC2
  • InChi: 1S/C36H49NO8/c1-7-13-28-21-24(2)20-25(3)33(40)44-23-36(5,6)31(38)32(39)37-19-12-11-16-29(37)35(42)45-30(26(4)22-43-34(28)41)18-17-27-14-9-8-10-15-27/h7-10,14-15,21,25-26,28-30H,1,11-13,16-20,22-23H2,2-6H3/b24-21+/t25-,26+,28+,29-,30+/m0/s1
  • InChiKey: YBGJRVBWSWZLOW-BALPWGACSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens FK506 binding protein 1A, 12kDa Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Neospora caninum Peptidylprolyl isomerase D (Cyclophilin D), related Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium yoelii FK506-binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis fk506 binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09571 FK506-binding protein 4/5, putative Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium berghei peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis immunophilin, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09568 FK506-binding protein 1, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP5 protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidylprolyl isomerase-like protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 Get druggable targets OG5_126727 All targets in OG5_126727
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum FK506-binding protein 1A, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium knowlesi peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis fk506-binding protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative Get druggable targets OG5_126727 All targets in OG5_126727
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative FK506 binding protein 1A, 12kDa 108 aa 107 aa 48.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0089 0.2035 0.3363
Brugia malayi nuclear receptor RXR 0.0089 0.2035 0.3893
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Echinococcus granulosus ecdysone induced protein 78C 0.0189 0.5227 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0089 0.2035 0.3893
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.2035 0.3363
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0799
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0189 0.5227 1
Leishmania major fk506-binding protein 1-like protein 0.0065 0.1269 1
Schistosoma mansoni nuclear hormone receptor 0.0089 0.2035 0.3363
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Schistosoma mansoni thyroid hormone receptor 0.0189 0.5227 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0089 0.2035 0.3363
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0065 0.1269 0.2429
Brugia malayi hypothetical protein 0.01 0.2377 0.4547
Loa Loa (eye worm) hypothetical protein 0.0189 0.5227 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0189 0.5227 1
Schistosoma mansoni nuclear hormone receptor 0.0089 0.2035 0.3363
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.1269 0.1771
Loa Loa (eye worm) steroid hormone receptor 0.0189 0.5227 1
Brugia malayi nuclear receptor NHR-88 0.0189 0.5227 1
Brugia malayi nuclear hormone receptor 0.0089 0.2035 0.3893
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Loa Loa (eye worm) hypothetical protein 0.0189 0.5227 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0189 0.5227 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0189 0.5227 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0089 0.2035 0.3363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Loa Loa (eye worm) hypothetical protein 0.01 0.2377 0.4547
Brugia malayi Nuclear hormone receptor E75 0.0089 0.2035 0.3893
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0065 0.1269 0.5
Schistosoma mansoni immunophilin 0.0056 0.0983 0.1175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0189 0.5227 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.01 0.2377 0.4074
Loa Loa (eye worm) carboxylesterase 0.0039 0.0418 0.0799
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.5227 1
Schistosoma mansoni nuclear receptor nhr-48 0.0089 0.2035 0.3363
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.1269 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0189 0.5227 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0065 0.1269 0.5
Brugia malayi Nuclear hormone receptor E75 0.0089 0.2035 0.3893
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0089 0.2035 0.3893
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.1269 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0189 0.5227 1
Loa Loa (eye worm) FKBP5 protein 0.0065 0.1269 0.2429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0799
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0189 0.5227 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0065 0.1269 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.5227 1
Echinococcus multilocularis FTZ F1 alpha 0.0189 0.5227 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0799
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.5227 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0065 0.1269 0.1771
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0189 0.5227 1
Schistosoma mansoni RAR-like nuclear receptor 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.01 0.2377 0.4547
Loa Loa (eye worm) hypothetical protein 0.01 0.2377 0.4547
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.1269 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0039 0.0418 0.0799
Loa Loa (eye worm) hypothetical protein 0.0189 0.5227 1
Brugia malayi Carboxylesterase family protein 0.0039 0.0418 0.0799
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.1269 1
Trichomonas vaginalis immunophilin, putative 0.0065 0.1269 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0799
Schistosoma mansoni coup transcription factor 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0799
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.2377 0.4547
Loa Loa (eye worm) hypothetical protein 0.0189 0.5227 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0065 0.1269 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0189 0.5227 1
Brugia malayi hypothetical protein 0.0089 0.2035 0.3893
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0089 0.2035 0.3363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.5227 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.1269 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.2035 0.3363
Brugia malayi Carboxylesterase family protein 0.0039 0.0418 0.0799
Loa Loa (eye worm) hypothetical protein 0.0189 0.5227 1
Brugia malayi hypothetical protein 0.01 0.2377 0.4547
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0189 0.5227 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0089 0.2035 0.3363
Echinococcus granulosus FTZ F1 alpha 0.0189 0.5227 1
Brugia malayi nuclear receptor NHR-88 0.0089 0.2035 0.3893
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0089 0.2035 0.3363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.2035 0.3363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.5227 1
Brugia malayi tailless protein 0.0089 0.2035 0.3893
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.01 0.2377 0.4547
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.5227 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0065 0.1269 0.5
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Loa Loa (eye worm) carboxylesterase 0.0039 0.0418 0.0799
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0189 0.5227 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.0983 0.1175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.5227 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.2035 0.3363
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0189 0.5227 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0189 0.5227 1
Brugia malayi Nuclear hormone receptor-like 1 0.0189 0.5227 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.2035 0.3363
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0189 0.5227 1
Schistosoma mansoni immunophilin 0.0065 0.1269 0.1771
Brugia malayi nuclear hormone receptor 0.0189 0.5227 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.01 0.2377 0.4074
Brugia malayi nuclear hormone receptor family member nhr-6 0.0089 0.2035 0.3893
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0799
Onchocerca volvulus Protein ultraspiracle homolog 0.0189 0.5227 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0089 0.2035 0.3363
Brugia malayi conserved hypotetical protein 0.0089 0.2035 0.3893
Brugia malayi hypothetical protein 0.0039 0.0418 0.0799
Brugia malayi Steroid receptor seven-up type 2 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Schistosoma mansoni nuclear receptor 0.0089 0.2035 0.3363
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.1269 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0338 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.2035 0.3363
Brugia malayi ecdysone receptor 0.0089 0.2035 0.3893
Onchocerca volvulus 0.0089 0.2035 0.3363
Schistosoma mansoni nuclear receptor 0.0089 0.2035 0.3363
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0189 0.5227 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.5227 1
Brugia malayi steroid hormone receptor 0.0189 0.5227 1
Brugia malayi ecdysteroid receptor 0.0189 0.5227 1
Loa Loa (eye worm) nuclear hormone receptor 0.0089 0.2035 0.3893
Brugia malayi Carboxylesterase family protein 0.0039 0.0418 0.0799
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0189 0.5227 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0065 0.1269 0.2429
Trichomonas vaginalis fk506-binding protein, putative 0.0065 0.1269 1
Loa Loa (eye worm) hypothetical protein 0.01 0.2377 0.4547
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Echinococcus granulosus nuclear receptor nhr 48 0.0089 0.2035 0.3363
Schistosoma mansoni zinc finger protein 0.0089 0.2035 0.3363
Loa Loa (eye worm) hypothetical protein 0.0189 0.5227 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.1269 1
Loa Loa (eye worm) DR-78 0.0089 0.2035 0.3893
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.0983 0.1175
Leishmania major peptidylprolyl isomerase-like protein 0.0065 0.1269 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0189 0.5227 1
Echinococcus multilocularis fk506 binding protein 0.0065 0.1269 0.1771
Schistosoma mansoni steroid hormone receptor ad4bp 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.1269 0.1771
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0189 0.5227 1
Loa Loa (eye worm) carboxylesterase 0.0039 0.0418 0.0799
Loa Loa (eye worm) hypothetical protein 0.0189 0.5227 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0189 0.5227 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0189 0.5227 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0089 0.2035 0.3893
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Echinococcus multilocularis ecdysone induced protein 78C 0.0189 0.5227 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.5227 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0189 0.5227 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0089 0.2035 0.3893
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0799
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0065 0.1269 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0799
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0189 0.5227 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0189 0.5227 1
Brugia malayi nuclear receptor RXR 0.01 0.2377 0.4547
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0189 0.5227 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0189 0.5227 1
Schistosoma mansoni immunophilin 0.0065 0.1269 0.1771
Brugia malayi Carboxylesterase family protein 0.0039 0.0418 0.0799
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.1269 1
Brugia malayi orphan nuclear receptor NR2E1 0.0089 0.2035 0.3893
Brugia malayi Carboxylesterase family protein 0.0039 0.0418 0.0799
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.2377 0.4547
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Brugia malayi nuclear receptor NHR-67 0.0089 0.2035 0.3893
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.01 0.2377 0.4074
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0065 0.1269 0.1269
Brugia malayi Carboxylesterase family protein 0.0039 0.0418 0.0799
Schistosoma mansoni thyroid hormone receptor 0.0189 0.5227 1
Onchocerca volvulus 0.0189 0.5227 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.2035 0.3363
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0065 0.1269 0.1771
Schistosoma mansoni retinoid-x-receptor (RXR) 0.01 0.2377 0.4074
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0065 0.1269 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.2035 0.3893
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0799
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0983 0.188
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.2035 0.3363
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0065 0.1269 0.2429
Schistosoma mansoni nuclear hormone receptor 0.0189 0.5227 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0189 0.5227 1
Loa Loa (eye worm) hypothetical protein 0.01 0.2377 0.4547
Onchocerca volvulus Bile acid receptor homolog 0.0189 0.5227 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0089 0.2035 0.3363
Brugia malayi hypothetical protein 0.0089 0.2035 0.3893

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 6000 nM Compound was tested for inhibitory activity against FK506 binding protein 12 (FKBP12) ChEMBL. No reference
Ki app (binding) = 6000 nM Compound was tested for inhibitory activity against FK506 binding protein 12 (FKBP12) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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