Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydroorotate dehydrogenase (quinone) | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | dihydroorotate dehydrogenase (quinone) | 395 aa | 361 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0078 | 0.2913 | 0.2913 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0275 | 0.0275 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0343 | 0.0925 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.1733 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0343 | 0.0343 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1156 | 0.1156 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1163 | 0.6709 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2913 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2913 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2913 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.2913 | 0.7864 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.02 | 1 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.0638 | 0.1721 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.02 | 1 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.0638 | 0.1721 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.2913 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0343 | 0.1976 |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2913 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1156 | 0.1156 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0092 | 0.3704 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.02 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.02 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.02 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1156 | 0.6667 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.02 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0275 | 0.1586 |
Onchocerca volvulus | Alhambra homolog | 0.0028 | 0 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0343 | 0.0925 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.2913 | 0.7864 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.2913 | 0.7864 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.2913 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.2913 | 0.7864 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0343 | 0.0343 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.2913 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0092 | 0.3704 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1156 | 0.6667 |
Schistosoma mansoni | jumonji domain containing protein | 0.0073 | 0.2608 | 0.2608 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0275 | 0.0275 |
Brugia malayi | jmjC domain containing protein | 0.0092 | 0.3704 | 0.3704 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.56 uM | Inhibition of human recombinant DHODH | LITERATURE. | 27994748 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.