TDR Targets

Basic information

Technical information

TDR Targets ID: 186729
Name: 6-(4-imidazol-1-ylphenoxy)-N,N-dimethylhexan- 1-amine
MW: 287.4 | Formula: C17H25N3O
H donors: 0 H acceptors: 1 LogP: 3.11 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCCCCCOc1ccc(cc1)n1cncc1)C
InChi: 1S/C17H25N3O/c1-19(2)12-5-3-4-6-14-21-17-9-7-16(8-10-17)20-13-11-18-15-20/h7-11,13,15H,3-6,12,14H2,1-2H3
InChiKey: FIFQJYUSSPRJIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-(4-imidazol-1-ylphenoxy)-N,N-dimethyl-hexan-1-amine
6-[4-(1-imidazolyl)phenoxy]-N,N-dimethyl-1-hexanamine
6-(4-imidazol-1-ylphenoxy)hexyl-dimethyl-amine
6-[4-(1-imidazolyl)phenoxy]-N,N-dimethylhexan-1-amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 1, subfamily A, polypeptide 2	Starlite/ChEMBL	References
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Curated by TDR Targets	References
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	Starlite/ChEMBL	References
Homo sapiens	cytochrome P450, family 2, subfamily D, polypeptide 6	Starlite/ChEMBL	References
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 19	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania infantum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Plasmodium yoelii	thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	ko:K00560 thymidylate synthase [EC2.1.1.45], putative	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Brugia malayi	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Cryptosporidium parvum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus granulosus	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Theileria parva	dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania major	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium ulcerans	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania braziliensis	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Plasmodium berghei	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei gambiense	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Cryptosporidium hominis	chain A, crystal structure of Dhfr	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus multilocularis	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Plasmodium knowlesi	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania donovani	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Neospora caninum	Bifunctional dihydrofolate reductase-thymidylate synthase, related	Get druggable targets OG5_127385	All targets in OG5_127385
Babesia bovis	dihydrofolate reductase/thymidilate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Onchocerca volvulus		Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	cytochrome p450-like protein	cytochrome P450, family 2, subfamily C, polypeptide 19	490 aa	411 aa	23.1 %
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %
Brugia malayi	Cytochrome P450 family protein	cytochrome P450, family 1, subfamily A, polypeptide 2	516 aa	470 aa	26.2 %
Brugia malayi	cytochrome P450	cytochrome P450, family 2, subfamily D, polypeptide 6	497 aa	425 aa	32.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ephrin receptor	0.0269	0.3554	0.3554
Schistosoma mansoni	hypothetical protein	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0393	0.5577	0.4938
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0269	0.3554	0.3554
Toxoplasma gondii	protein kinase	0.0269	0.3554	1
Schistosoma mansoni	serine/threonine protein kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0662	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0269	0.3554	1
Echinococcus multilocularis	protein tyrosine kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trypanosoma cruzi	protein kinase, putative	0.0269	0.3554	1
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0662	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0662	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0269	0.3554	1
Onchocerca volvulus		0.0662	1	1
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.013	0.1262	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0269	0.3554	0.3554
Echinococcus granulosus	activated cdc42 kinase 1	0.0269	0.3554	0.3554
Plasmodium falciparum	protein kinase, putative	0.0269	0.3554	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0662	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0269	0.3554	1
Schistosoma mansoni	protein tyrosine kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	ephrin receptor	0.0269	0.3554	0.3554
Echinococcus multilocularis	tensin	0.0393	0.5577	0.5577
Echinococcus multilocularis	signal transduction protein lnk realted	0.0393	0.5577	0.5577
Brugia malayi	hypothetical protein	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0393	0.5577	0.4938
Echinococcus granulosus	activated cdc42 kinase 1	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0269	0.3554	0.3554
Brugia malayi	Variant SH3 domain containing protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Onchocerca volvulus		0.0393	0.5577	0.4938
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	serine/threonine protein kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	tensin	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0393	0.5577	0.4938
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0393	0.5577	0.5577
Echinococcus multilocularis	tyrosine kinase	0.0662	1	1
Schistosoma mansoni	tyrosine kinase	0.0662	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0269	0.3554	0.3554
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Trichomonas vaginalis	conserved hypothetical protein	0.0269	0.3554	1
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0269	0.3554	0.3554
Echinococcus granulosus	insulin receptor	0.0269	0.3554	0.3554
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Loa Loa (eye worm)	TK protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0393	0.5577	0.5577
Trichomonas vaginalis	AGC family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0662	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0393	0.5577	0.5577
Schistosoma mansoni	tyrosine kinase	0.0662	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0269	0.3554	0.3554
Brugia malayi	ephrin receptor 1 precursor	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	tensin-related	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TK/ALK protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0393	0.5577	0.5577
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0662	1	1
Schistosoma mansoni	tensin	0.0393	0.5577	0.5577
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0393	0.5577	0.5577
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0393	0.5577	0.4938
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	shc transforming protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0662	1	1
Brugia malayi	SH2 domain containing protein	0.0393	0.5577	0.5577
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Brugia malayi	Guanylyl cyclase protein 23	0.0269	0.3554	0.3554
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0662	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0393	0.5577	0.5577
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0269	0.3554	0.3554
Onchocerca volvulus	Tyrosine kinase homolog	0.0269	0.3554	0.2623
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0269	0.3554	0.3554
Echinococcus multilocularis	SH2 motif	0.0393	0.5577	0.5577
Echinococcus multilocularis	tyrosine protein kinase csk	0.0269	0.3554	0.3554
Echinococcus multilocularis	SH2 motif	0.0393	0.5577	0.5577
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0393	0.5577	0.5577
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Brugia malayi	SH2 domain containing protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0269	0.3554	0.3554
Loa Loa (eye worm)	thymidylate synthase	0.013	0.1262	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0269	0.3554	0.3554
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0269	0.3554	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0662	1	1
Echinococcus multilocularis	SH2 motif	0.0393	0.5577	0.5577
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Onchocerca volvulus		0.0269	0.3554	0.2623
Loa Loa (eye worm)	TK/EPH protein kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	SHC transforming protein 3	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	thymidylate synthase	0.013	0.1262	0.1262
Onchocerca volvulus		0.0269	0.3554	0.2623
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0662	1	1
Echinococcus granulosus	activin receptor type	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/INSR protein kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	CAMK family protein kinase	0.0269	0.3554	1
Giardia lamblia	Protein 21.1	0.0269	0.3554	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Variant SH3 domain containing protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	tyrosine kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	protein tyrosine kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0269	0.3554	0.3554
Echinococcus multilocularis	epidermal growth factor receptor	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0662	1	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0662	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Brugia malayi	hypothetical protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TK protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/FER protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0269	0.3554	0.3554
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0662	1	1
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Entamoeba histolytica	SH2 domain containing protein	0.0393	0.5577	0.3138
Loa Loa (eye worm)	TK protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0662	1	1
Schistosoma mansoni	tensin	0.0393	0.5577	0.5577
Echinococcus granulosus	epidermal growth factor receptor	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TK/DDR protein kinase	0.0269	0.3554	0.3554
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0269	0.3554	1
Trichomonas vaginalis	STE family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0269	0.3554	0.3554
Mycobacterium tuberculosis	Hypothetical protein	0.0062	0.0145	0.1148
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	vav2	0.0393	0.5577	0.5577
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0393	0.5577	0.3138
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0662	1	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0269	0.3554	0.2623
Schistosoma mansoni	tyrosine kinase	0.0662	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	SH2 domain-containing protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0269	0.3554	0.3554
Echinococcus multilocularis	protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/ABL protein kinase	0.0662	1	1
Brugia malayi	SH2 domain containing protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	SH2 domain containing protein 7	0.0393	0.5577	0.5577
Echinococcus multilocularis	epidermal growth factor receptor	0.0269	0.3554	0.3554
Schistosoma mansoni	suppressor of cytokine signaling	0.0393	0.5577	0.5577
Plasmodium vivax	protein kinase, putative	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Brugia malayi	SRC-1	0.0662	1	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0269	0.3554	0.3554
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0269	0.3554	0.3554
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0393	0.5577	0.5577
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0393	0.5577	0.5577
Echinococcus granulosus	protein kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0662	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0662	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TK protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0269	0.3554	0.2623
Echinococcus multilocularis	insulin receptor	0.0269	0.3554	0.3554
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0269	0.3554	0.3554
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0662	1	1
Schistosoma mansoni	GTPase activating protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Brugia malayi	protein-tyrosine kinase	0.0662	1	1
Loa Loa (eye worm)	TK protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0662	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Raf kinase	0.0269	0.3554	0.3554
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0269	0.3554	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Brugia malayi	SH2 domain containing protein	0.0393	0.5577	0.5577
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0269	0.3554	0.3554
Echinococcus multilocularis	thymidylate synthase	0.013	0.1262	0.1262
Loa Loa (eye worm)	TK protein kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	tyrosine protein kinase shark	0.0662	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0269	0.3554	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0269	0.3554	0.2623
Trichomonas vaginalis	conserved hypothetical protein	0.0269	0.3554	1
Onchocerca volvulus		0.0393	0.5577	0.4938
Schistosoma mansoni	tensin	0.0393	0.5577	0.5577
Schistosoma mansoni	growth factor receptor-bound protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	c src tyrosine kinase	0.0662	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0393	0.5577	0.5577
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0662	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0393	0.5577	0.5577
Leishmania major	protein kinase, putative	0.0269	0.3554	1
Echinococcus granulosus	N chimaerin	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	hypothetical protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	serine/threonine RGC	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0269	0.3554	0.3554
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0393	0.5577	0.5577
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0269	0.3554	0.3554
Echinococcus granulosus	SH2 motif	0.0393	0.5577	0.5577
Schistosoma mansoni	serine/threonine protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0662	1	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0269	0.3554	0.2623
Echinococcus multilocularis	tyrosine protein kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	tensin	0.0393	0.5577	0.5577
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0662	1	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	adapter molecule crk	0.0393	0.5577	0.5577
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.013	0.1262	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0393	0.5577	0.5577
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0269	0.3554	0.2623
Trypanosoma cruzi	protein kinase, putative	0.0269	0.3554	1
Loa Loa (eye worm)	TK protein kinase	0.0662	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0269	0.3554	0.3554
Schistosoma mansoni	SH2A	0.0393	0.5577	0.5577
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	transfer RNA-Thr	0.0269	0.3554	0.3554
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine protein kinase shark	0.0662	1	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0269	0.3554	0.3554
Brugia malayi	SH2 domain containing protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0269	0.3554	0.3554
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0662	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0393	0.5577	0.5577
Echinococcus granulosus	tyrosine protein kinase Blk	0.0662	1	1
Schistosoma mansoni	tensin-related	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus multilocularis	protein kinase	0.0269	0.3554	0.3554
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0269	0.3554	1
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Brugia malayi	Tyrosine-protein kinase PR2	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0393	0.5577	0.5577
Echinococcus granulosus	integrin linked protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	serine/threonine protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0269	0.3554	0.3554
Trypanosoma brucei	protein kinase, putative	0.0269	0.3554	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0269	0.3554	0.3554
Schistosoma mansoni	nck2/grb4	0.0393	0.5577	0.5577
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0269	0.3554	1
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	N chimaerin	0.0393	0.5577	0.5577
Echinococcus multilocularis	tyrosine protein kinase csk	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0393	0.5577	0.5577
Loa Loa (eye worm)	SRC-1	0.0662	1	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0662	1	1
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Brugia malayi	integrin-linked kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0269	0.3554	1
Schistosoma mansoni	hypothetical protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Echinococcus granulosus	SH2 motif	0.0393	0.5577	0.5577
Echinococcus multilocularis	heat shock protein 70	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0269	0.3554	0.3554
Plasmodium falciparum	tyrosine kinase-like protein	0.0269	0.3554	1
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/CSK protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.3554	0.3554
Echinococcus granulosus	natriuretic peptide receptor 1	0.0269	0.3554	0.3554
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0662	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	integrin linked protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0269	0.3554	0.3554
Brugia malayi	Sex muscle abnormal protein 5	0.0393	0.5577	0.5577
Echinococcus granulosus	tyrosine protein kinase pr2	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0662	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Onchocerca volvulus		0.0393	0.5577	0.4938
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Brugia malayi	SH2 domain containing protein	0.0662	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0393	0.5577	0.5577
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0662	1	1
Onchocerca volvulus		0.0662	1	1
Echinococcus granulosus	tyrosine kinase	0.0662	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0662	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	STAT protein	0.0393	0.5577	0.5577
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Brugia malayi	SH2 domain containing protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	conserved hypothetical protein	0.0269	0.3554	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0662	1	1
Brugia malayi	C-terminal src kinase protein 1	0.0269	0.3554	0.3554
Trichomonas vaginalis	conserved hypothetical protein	0.0269	0.3554	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TK/FER protein kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/ROR protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/FER protein kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	SHC transforming protein 3	0.0393	0.5577	0.5577
Echinococcus multilocularis	activated cdc42 kinase 1	0.0269	0.3554	0.3554
Onchocerca volvulus		0.0269	0.3554	0.2623
Entamoeba histolytica	protein kinase, putative	0.0393	0.5577	0.3138
Plasmodium falciparum	protein kinase, putative	0.0269	0.3554	1
Giardia lamblia	Kinase, NEK	0.0269	0.3554	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	hypothetical protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/FER protein kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0269	0.3554	1
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0662	1	1
Echinococcus multilocularis		0.0393	0.5577	0.5577
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0393	0.5577	0.5577
Giardia lamblia	Kinase, NEK	0.0269	0.3554	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	tyrosine kinase	0.0662	1	1
Brugia malayi	RhoGAP domain containing protein	0.0393	0.5577	0.5577
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0393	0.5577	0.5577
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Echinococcus granulosus	expressed conserved protein	0.0393	0.5577	0.5577
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0662	1	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	raf serine:threonine protein kinase	0.0269	0.3554	0.3554
Mycobacterium ulcerans	thymidylate synthase	0.013	0.1262	1
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0269	0.3554	0.3554
Leishmania major	protein kinase, putative	0.0269	0.3554	1
Plasmodium falciparum	protein kinase, putative	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	protein kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0662	1	1
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Onchocerca volvulus		0.0269	0.3554	0.2623
Brugia malayi	Protein kinase domain containing protein	0.0662	1	1
Leishmania major	hypothetical protein, conserved	0.0269	0.3554	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	receptor type guanylyl cyclase	0.0269	0.3554	0.3554
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0269	0.3554	0.3554
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine kinase	0.0662	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0662	1	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0662	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Toxoplasma gondii	STE kinase	0.0269	0.3554	1
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Onchocerca volvulus		0.0269	0.3554	0.2623
Chlamydia trachomatis	dihydrofolate reductase	0.0053	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0393	0.5577	0.5577
Echinococcus granulosus	NCK adaptor protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	TK/RYK protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Furin-like cysteine rich region family protein	0.0269	0.3554	0.3554
Echinococcus granulosus	epidermal growth factor receptor	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0393	0.5577	0.5577
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Receptor family ligand binding region containing protein	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0393	0.5577	0.5577
Brugia malayi	Tensin	0.0393	0.5577	0.5577
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0662	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0662	1	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Brugia malayi	hypothetical protein	0.0062	0.0145	0.0145
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Trypanosoma brucei	Pseudokinase, putative	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0269	0.3554	0.3554
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0662	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	TK protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0393	0.5577	0.5577
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0269	0.3554	0.3554
Brugia malayi	SH2 domain containing protein	0.0662	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0662	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0393	0.5577	0.5577
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0662	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0269	0.3554	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0662	1	1
Onchocerca volvulus		0.0393	0.5577	0.4938
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0393	0.5577	0.5577
Brugia malayi	hypothetical protein	0.0269	0.3554	0.3554
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0269	0.3554	0.3554
Echinococcus granulosus	c src tyrosine kinase	0.0662	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0393	0.5577	0.5577
Trichomonas vaginalis	conserved hypothetical protein	0.0269	0.3554	1
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0269	0.3554	0.3554
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Schistosoma mansoni	signal transduction protein lnk-related	0.0393	0.5577	0.5577
Onchocerca volvulus		0.0269	0.3554	0.2623
Plasmodium falciparum	tyrosine kinase-like protein	0.0269	0.3554	1
Trichomonas vaginalis	conserved hypothetical protein	0.0269	0.3554	1
Loa Loa (eye worm)	hypothetical protein	0.0269	0.3554	0.3554
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0183	0.2131	0.5826
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.013	0.1262	0.1262
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0269	0.3554	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0393	0.5577	0.5577
Echinococcus granulosus	tyrosine protein kinase Srms	0.0662	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0269	0.3554	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Trichomonas vaginalis	TK family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0393	0.5577	0.5577
Brugia malayi	thymidylate synthase	0.013	0.1262	0.1262
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	activin receptor type	0.0269	0.3554	0.3554
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0662	1	1
Brugia malayi	Protein kinase domain containing protein	0.0269	0.3554	0.3554
Schistosoma mansoni	serine/threonine protein kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Brugia malayi	hypothetical protein	0.0662	1	1
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0393	0.5577	0.5577
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0269	0.3554	0.3554
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0269	0.3554	1
Echinococcus multilocularis	FL cytokine receptor	0.0269	0.3554	0.3554
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0269	0.3554	0.3554
Echinococcus granulosus	growth factor receptor bound protein 2	0.0393	0.5577	0.5577
Brugia malayi	SH2 domain containing protein	0.0393	0.5577	0.5577
Echinococcus multilocularis	tyrosine protein kinase csk	0.0269	0.3554	0.3554
Giardia lamblia	Kinase	0.0269	0.3554	0.5
Schistosoma mansoni	tyrosine kinase	0.0269	0.3554	0.3554
Trichomonas vaginalis	TKL family protein kinase	0.0269	0.3554	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0269	0.3554	0.3554
Brugia malayi	Protein kinase domain containing protein	0.0662	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0269	0.3554	0.3554

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.2 nM	Inhibition of 20-HETE synthesis in human renal microsomes	ChEMBL.	14698153
IC50 (ADMET)	= 410 nM	Inhibition of cytochrome P450 2D6	ChEMBL.	14698153
IC50 (ADMET)	= 410 nM	Inhibition of cytochrome P450 2D6	ChEMBL.	14698153
IC50 (ADMET)	= 800 nM	Inhibition of cytochrome P450 1A2	ChEMBL.	14698153
IC50 (ADMET)	= 800 nM	Inhibition of cytochrome P450 1A2	ChEMBL.	14698153
IC50 (ADMET)	= 4460 nM	Inhibition of cytochrome P450 3A4	ChEMBL.	14698153
IC50 (ADMET)	= 4460 nM	Inhibition of cytochrome P450 3A4	ChEMBL.	14698153
IC50 (ADMET)	= 6220 nM	Inhibition of cytochrome P450 2C19	ChEMBL.	14698153
IC50 (ADMET)	= 6220 nM	Inhibition of cytochrome P450 2C19	ChEMBL.	14698153
IC50 (ADMET)	= 33200 nM	Inhibition of cytochrome P450 2C9	ChEMBL.	14698153
IC50 (ADMET)	= 33200 nM	Inhibition of cytochrome P450 2C9	ChEMBL.	14698153
logD	= 0.51	Distribution coefficient of compound was evaluated at pH 6.8	ChEMBL.	14698153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL113275
PubChem: 10108128

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 186729