Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.1766 | 0.1713 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0606 | 0.0545 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.1766 | 0.1766 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0606 | 0.0545 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.9481 | 0.9478 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0606 | 0.0639 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.4083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0606 | 0.0606 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0606 | 0.0545 |
Echinococcus multilocularis | geminin | 0.0173 | 0.7498 | 0.7482 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.4083 | 0.4045 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.9481 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.1766 | 0.1713 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.9481 | 0.9481 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.9481 | 0.9478 |
Echinococcus granulosus | geminin | 0.0173 | 0.7498 | 0.7482 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1713 | 0.1713 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0606 | 0.0639 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0606 | 0.0606 |
Schistosoma mansoni | lamin | 0.0027 | 0.0606 | 0.0545 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0582 | 0.0582 |
Brugia malayi | hypothetical protein | 0.0104 | 0.422 | 0.4451 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0064 | 0.0068 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.4083 | 0.4307 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0606 | 0.0606 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0606 | 0.0545 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1713 | 0.1713 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.4083 | 0.4045 |
Schistosoma mansoni | lamin | 0.0027 | 0.0606 | 0.0545 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.9481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4083 | 0.4083 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0606 | 0.0545 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0064 | 0.0068 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0.4083 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0064 | 0.0064 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.1766 | 0.1713 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.9481 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.1766 | 0.1863 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.095 | 0.0891 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.9481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.095 | 0.095 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.9481 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.9481 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.4083 | 0.4045 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.4083 | 0.4307 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.6611 | 0.6611 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1713 | 0.1806 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.4083 | 0.4045 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.4083 | 0.4307 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0225 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.9481 | 0.9481 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.1766 | 0.1713 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0225 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.4083 | 0.4307 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.9481 | 0.9478 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.1766 | 0.1713 |
Brugia malayi | hypothetical protein | 0.0154 | 0.6611 | 0.6972 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0101 | 0.4083 | 0.4083 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0225 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1713 | 0.1806 |
Echinococcus granulosus | lamin | 0.0027 | 0.0606 | 0.0545 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.095 | 0.1002 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Onchocerca volvulus | 0.0154 | 0.6611 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0064 | 0.0064 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0606 | 0.0545 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.1766 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7498 | 0.7482 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7498 | 0.7482 |
Schistosoma mansoni | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4083 | 0.4083 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.9481 | 0.9478 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.4083 | 0.4307 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.5 nM | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | ChEMBL. | 12039560 |
Ki (binding) | = 12 nM | Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes | ChEMBL. | 12039560 |
Ki (binding) | = 56 nM | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | ChEMBL. | 12039560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.