TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 426.843 | Formula: C23H17ClF2N2O2
H donors: 1 H acceptors: 2 LogP: 5.06 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)C(=NC(C(=O)N2C)Cc1ccc(c(c1)F)F)c1ccc(cc1)O
InChi: 1S/C23H17ClF2N2O2/c1-28-21-9-5-15(24)12-17(21)22(14-3-6-16(29)7-4-14)27-20(23(28)30)11-13-2-8-18(25)19(26)10-13/h2-10,12,20,29H,11H2,1H3
InChiKey: LJJOUJDXOHPAGX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0025	0.0025
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0025	0.0025	0.0025
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0025	0.0025	0.0043
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.02	0.02
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0025	0.0025
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0025	0.044
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1472	1	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0104	0.0569	0.0569
Brugia malayi	serine/threonine-protein kinase plk-2	0.0104	0.0569	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0104	0.0569	0.0975
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0025	0.0025
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0025	0.0025
Onchocerca volvulus		0.009	0.0472	0.0448
Schistosoma mansoni	hypothetical protein	0.0025	0.0025	0.0025
Schistosoma mansoni	kinase	0.0053	0.0217	0.0217
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0025	0.0025	0.5
Schistosoma mansoni	hypothetical protein	0.0091	0.0481	0.0481
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0025	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0429	0.0429
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0314	0.0537
Onchocerca volvulus		0.1472	1	1
Leishmania major	hypothetical protein, unknown function	0.0025	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0186	0.1138	0.1138
Toxoplasma gondii	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0052	0.0215	0.6595
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0104	0.0569	0.0569
Schistosoma mansoni	hypothetical protein	0.0186	0.1138	0.1138
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.0314	0.0314
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0025	0.044
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0628	0.4183	0.4183
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.02	0.02
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0025	0.0025
Mycobacterium ulcerans	phosphoglycerate mutase	0.0025	0.0025	0.0043
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0025	0.0025	0.0043
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0025	0.0025
Mycobacterium ulcerans	phosphoglycerate mutase	0.0025	0.0025	0.0043
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0025	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0025	0.0025	0.0025
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0314	0.0537
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1447	0.9829	0.9829
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0025	0.0025
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0091	0.0481	0.0481
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0091	0.0481	0.0481
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0025	0.0025	0.5
Echinococcus multilocularis	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0045	0.0161	0.0161
Leishmania major	glycerolphosphate mutase, putative	0.0025	0.0025	0.0025
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0025	0.0025	0.0025
Echinococcus multilocularis	microtubule associated protein 2	0.0758	0.5082	0.5082
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0025	0.0025
Echinococcus granulosus	geminin	0.0186	0.1138	0.1138
Loa Loa (eye worm)	hypothetical protein	0.1447	0.9829	0.9829
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.0569	0.0569
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.0569	0.0569
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0104	0.0569	0.0569
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.02	0.3518
Schistosoma mansoni	hypothetical protein	0.0025	0.0025	0.0025
Echinococcus granulosus	microtubule associated protein 2	0.0758	0.5082	0.5082
Schistosoma mansoni	apoptosis regulator bax	0.0091	0.0481	0.0481
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0569	1
Loa Loa (eye worm)	phosphoglycerate mutase	0.0025	0.0025	0.0025
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.0314	0.0314
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.1447	0.9829	0.9829
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0025	0.0025	0.0025
Loa Loa (eye worm)	transport to inner mitochondrial membrane family member	0.0052	0.0215	0.0215
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0025	0.0025	0.0025
Treponema pallidum	phosphoglyceromutase	0.0025	0.0025	0.5
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0025	0.0025
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0025	0.0025
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1472	1	1
Brugia malayi	phosphoglycerate mutase family protein	0.0025	0.0025	0.044
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0025	0.0025	0.0025
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0569	1
Schistosoma mansoni	hypothetical protein	0.0025	0.0025	0.0025
Toxoplasma gondii	mitochondrial inner membrane translocase subunit TIM17, putative	0.0045	0.0161	0.4703
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0025	0.0025	0.5
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0045	0.0161	0.7131
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0025	0.0025	0.0799
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0025	0.0025	0.0025
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0025	0.0025
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0025	0.044
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.0314	1
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0569	1
Trypanosoma brucei	polo-like protein kinase	0.0104	0.0569	0.0569
Leishmania major	phosphoglycerate mutase protein, putative	0.0025	0.0025	0.0025
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0314	0.0314
Schistosoma mansoni	hypothetical protein	0.0025	0.0025	0.0025
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.009	0.0472	0.0472
Loa Loa (eye worm)	hypothetical protein	0.1472	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0208	0.3654
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0052	0.0215	1
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0025	0.0025	0.0799
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1472	1	1
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0045	0.0161	0.2825
Schistosoma mansoni	hypothetical protein	0.0091	0.0481	0.0481
Mycobacterium tuberculosis	Conserved protein	0.0025	0.0025	0.0799
Schistosoma mansoni	6-phosphofructokinase	0.1472	1	1
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.1472	1	1
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.009	0.0472	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0045	0.0161	0.0161
Brugia malayi	Mitochondrial import inner membrane translocase subunit TIM10	0.0052	0.0215	0.3785
Onchocerca volvulus		0.009	0.0472	0.0448
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0025	0.0025	0.0799
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.0869	0.5842	1
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0025	0.0025	0.0043
Leishmania major	hypothetical protein, conserved	0.0025	0.0025	0.0025
Brugia malayi	hypothetical protein	0.004	0.0131	0.2302
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0569	1
Mycobacterium ulcerans	hypothetical protein	0.0869	0.5842	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0472	0.0472
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.0314	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0104	0.0569	0.0569
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0025	0.044
Loa Loa (eye worm)	hypothetical protein	0.0844	0.5671	0.5671
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0569	1
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0091	0.0481	0.0481
Mycobacterium ulcerans	acid phosphatase	0.0025	0.0025	0.0043
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0025	0.0025	0.0799
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0025	0.0025	0.0025
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0025	0.0025
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.0628	0.4183	0.4183
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.0314	0.0314
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0208	0.3654
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.02	0.02
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.02	0.02
Echinococcus multilocularis	geminin	0.0186	0.1138	0.1138
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0025	0.0025	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0025	0.0025	0.0025
Echinococcus granulosus	expressed protein	0.0052	0.0215	0.0215
Brugia malayi	UBASH3A protein homolog	0.0025	0.0025	0.044
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0025	0.0025
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0025	0.0025	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0025	0.044
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0869	0.5842	1
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0045	0.0161	0.2825
Schistosoma mansoni	mitochondrial import inner membrane translocase subunit tim10	0.0052	0.0215	0.0215
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.02	0.02
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0025	0.0025	0.0025
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0025	0.0025	0.0799
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0045	0.0161	0.7131
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0045	0.0161	0.2825
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0025	0.0025	0.0025
Schistosoma mansoni	phosphoglycerate mutase	0.0025	0.0025	0.0025
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0025	0.044
Mycobacterium leprae	conserved hypothetical protein	0.0025	0.0025	0.5
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0025	0.0025	0.0799
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0025	0.0025	0.0025
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.1447	0.9829	0.9829
Mycobacterium ulcerans	lipoprotein LpqD	0.0025	0.0025	0.0043
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.02	0.02
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0091	0.0481	0.0481
Mycobacterium leprae	conserved hypothetical protein	0.0025	0.0025	0.5
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0025	0.0025	0.0025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.02	0.02
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0569	1
Toxoplasma gondii	TIM10 family protein, putative	0.0052	0.0215	0.6595
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0025	0.0025
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0025	0.0043
Brugia malayi	hypothetical protein	0.004	0.0131	0.2302
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0025	0.0025	0.0025
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0025	0.0025	0.0043
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.02	0.02
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0025	0.0025	0.0025
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0091	0.0481	0.845
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0025	0.0025	0.0025
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0025	0.0025
Schistosoma mansoni	phosphoglycerate mutase	0.0025	0.0025	0.0025
Mycobacterium ulcerans	hydrolase MutT1	0.0025	0.0025	0.0043
Brugia malayi	Cation transporter family protein	0.009	0.0472	0.8283
Giardia lamblia	Kinase, PLK	0.0104	0.0569	0.0975
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0314	0.0537
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0104	0.0569	0.0546
Mycobacterium ulcerans	phosphoglyceromutase	0.0025	0.0025	0.0043
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0025	0.0025
Schistosoma mansoni	microtubule-associated protein tau	0.0758	0.5082	0.5082
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0025	0.0025	0.5
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0161	0.0161
Mycobacterium leprae	conserved hypothetical protein	0.0025	0.0025	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.1447	0.9829	0.9829
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0025	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0025	0.0025	0.0025
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0052	0.0215	1
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0025	0.0025	0.0799
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0314	0.0314
Schistosoma mansoni	hypothetical protein	0.0091	0.0481	0.0481
Giardia lamblia	Hypothetical protein	0.0869	0.5842	1
Mycobacterium tuberculosis	Conserved protein	0.0025	0.0025	0.0799
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1472	1	1
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0025	0.0025
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0569	1
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0025	0.0025	0.0025
Leishmania major	hypothetical protein, conserved	0.0025	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0025	0.0025
Giardia lamblia	Hypothetical protein	0.0869	0.5842	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0472	0.0472
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0025	0.0025
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0628	0.4183	0.4183
Mycobacterium leprae	probable isochorismate synthase EntC	0.0025	0.0025	0.5
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0025	0.0025	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0481	0.0481
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0025	0.0025
Loa Loa (eye worm)	apoptosis regulator protein	0.0091	0.0481	0.0481
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0025	0.0025
Onchocerca volvulus		0.009	0.0472	0.0448
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0091	0.0481	0.0481
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0025	0.0025	0.5
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0025	0.0043
Echinococcus multilocularis	expressed protein	0.0052	0.0215	0.0215
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0628	0.4183	0.4183
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0025	0.044
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0025	0.0025
Leishmania major	hypothetical protein, conserved	0.0025	0.0025	0.0025
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.0569	0.0569
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0025	0.0025	0.0025
Leishmania major	phosphoglycerate mutase, putative	0.0025	0.0025	0.0025
Brugia malayi	phosphoglycerate mutase family protein	0.0025	0.0025	0.044

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 10 uM	Lymphotoxic activity against immortalized Ramos B cells in culture	ChEMBL.	12951119
EC50 (functional)	= 10 uM	Lymphotoxic activity against immortalized Ramos B cells in culture	ChEMBL.	12951119
Inhibition (functional)	= 0 %	Inhibition of Ramos B cells death in the presence of 20 uM methylating phenol (Compound 20)	ChEMBL.	12951119
Inhibition (functional)	= 0 %	Inhibition of Ramos B cells death in the presence of 20 uM methylating phenol (Compound 20)	ChEMBL.	12951119
Inhibition (functional)	= 59 %	Inhibition of Ramos B cells death in the presence of FK506 (1 uM)	ChEMBL.	12951119
Inhibition (functional)	= 59 %	Inhibition of Ramos B cells death in the presence of FK506 (1 uM)	ChEMBL.	12951119

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	12951119

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 186752