TDR Targets

Basic information

Technical information

TDR Targets ID: 186754
Name: 2-[4-[[4-hydroxy-3-(4-nitrophenyl)-5-propan-2 -ylphenyl]methyl]-3,5-dimethylphenoxy]acetic acid
MW: 449.496 | Formula: C26H27NO6
H donors: 2 H acceptors: 5 LogP: 6.36 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)COc1cc(C)c(c(c1)C)Cc1cc(C(C)C)c(c(c1)c1ccc(cc1)[N+](=O)[O-])O
InChi: 1S/C26H27NO6/c1-15(2)22-11-18(12-23-16(3)9-21(10-17(23)4)33-14-25(28)29)13-24(26(22)30)19-5-7-20(8-6-19)27(31)32/h5-11,13,15,30H,12,14H2,1-4H3,(H,28,29)
InChiKey: PBZAEAFSLYJVGD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[[4-hydroxy-3-isopropyl-5-(4-nitrophenyl)phenyl]methyl]-3,5-dimethyl-phenoxy]acetic acid
2-[4-[[4-hydroxy-3-isopropyl-5-(4-nitrophenyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
2-[4-[[4-hydroxy-3-(4-nitrophenyl)-5-propan-2-yl-phenyl]methyl]-3,5-dimethyl-phenoxy]ethanoic acid
2-[4-[4-hydroxy-3-isopropyl-5-(4-nitrophenyl)benzyl]-3,5-dimethyl-phenoxy]acetic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thyroid hormone receptor, alpha	Starlite/ChEMBL	References
Homo sapiens	thyroid hormone receptor, beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	thyroid hormone receptor alpha	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	expressed protein	Get druggable targets OG5_134830	All targets in OG5_134830
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Loa Loa (eye worm)	nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative	Get druggable targets OG5_134830	All targets in OG5_134830

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, beta	461 aa	414 aa	24.6 %
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, alpha	451 aa	372 aa	25.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0676	0.7299	1
Echinococcus multilocularis	calpain 5	0.0021	0.0042	0.0042
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0018	0.0016	0.0021
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0524	0.0718
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0027	0.0027
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0027	0.0037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0146	0.1427	0.1955
Trichomonas vaginalis	glutaminase, putative	0.0265	0.275	0.3767
Leishmania major	cathepsin L-like protease	0.0064	0.0524	0.0718
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0027	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0027	0.0037
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0027	0.0037
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0146	0.1427	0.1955
Echinococcus multilocularis	expressed protein	0.0376	0.397	0.397
Echinococcus multilocularis	calpain family protein 1, d	0.004	0.026	0.026
Loa Loa (eye worm)	transcriptional regulator	0.0146	0.1427	0.1955
Brugia malayi	ecdysteroid receptor	0.0035	0.0196	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0027	0.0037
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0035	0.0196	0.0196
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0027	0.0037
Onchocerca volvulus		0.0035	0.0196	1
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0146	0.1427	0.1955
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0196	0.0269
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0027	0.0037
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.013	0.0178
Brugia malayi	photoreceptor-specific nuclear receptor	0.0035	0.0196	0.0269
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0057	0.0448	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Loa Loa (eye worm)	calpain	0.0021	0.0042	0.0058
Brugia malayi	Nuclear hormone receptor-like 1	0.0306	0.3202	0.4387
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0035	0.0196	0.0269
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0027	0.0027
Loa Loa (eye worm)	glutaminase	0.0265	0.275	0.3767
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0035	0.0196	0.0269
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.1496	0.2049
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0027	0.0037
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0035	0.0196	0.0269
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0042	0.0058
Leishmania major	silent information regulator 2, putative	0.0676	0.7299	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.0502	0.5373	0.7361
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0027	0.0037
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0146	0.1427	0.1955
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0027	0.0037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0035	0.0196	0.0269
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0042	0.0058
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0676	0.7299	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0524	0.0718
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0035	0.0196	0.0269
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0035	0.0196	0.0269
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0035	0.0196	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0037
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0187	0.1878	0.1878
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0388	0.0532
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0027	0.0037
Echinococcus multilocularis	calpain 7 (C02 family)	0.0021	0.0042	0.0042
Echinococcus granulosus	calpain A	0.0021	0.0042	0.0058
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0146	0.1427	0.1955
Entamoeba histolytica	hypothetical protein	0.0019	0.0027	0.0037
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0502	0.5373	0.5373
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0035	0.0196	0.0269
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0035	0.0196	0.0196
Schistosoma mansoni	chromatin regulatory protein sir2	0.0676	0.7299	1
Leishmania major	sir2-family protein-like protein	0.0146	0.1427	0.1955
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0146	0.1427	0.1955
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0042	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0035	0.0196	0.0269
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0196	0.0269
Brugia malayi	Nuclear hormone receptor-like 1	0.0306	0.3202	0.4387
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0388	0.0532
Schistosoma mansoni	retinoic acid receptor RXR	0.0035	0.0196	0.0269
Entamoeba histolytica	hypothetical protein	0.0019	0.0027	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0035	0.0196	0.0269
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0502	0.5373	0.7361
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0018	0.0016	0.0021
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0027	0.0037
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0042	0.0058
Loa Loa (eye worm)	sirtuin 4	0.0146	0.1427	0.1955
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0037
Schistosoma mansoni	chromatin regulatory protein sir2	0.0146	0.1427	0.1955
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0035	0.0196	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0016	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0196	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0055	0.042	0.0576
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0037
Echinococcus multilocularis	hypothetical protein	0.0021	0.0042	0.0042
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0027	0.0037
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0027	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0191	0.0262
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0502	0.5373	0.7361
Brugia malayi	calpain family protein 1	0.0055	0.042	0.0576
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0388	0.0532
Schistosoma mansoni	coup transcription factor	0.0035	0.0196	0.0269
Echinococcus granulosus	expressed protein	0.0376	0.397	0.5439
Mycobacterium tuberculosis	Possible exported protein	0.0504	0.5396	1
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0037
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.013	0.0912
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0676	0.7299	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0388	0.0532
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0027	0.0027
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0027	0.0027
Echinococcus granulosus	FTZ F1 alpha	0.0035	0.0196	0.0269
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0027	0.0027
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0027	0.0037
Schistosoma mansoni	nuclear hormone receptor	0.0035	0.0196	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0016	0.0021
Loa Loa (eye worm)	calpain family protein 1	0.0055	0.042	0.0576
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0035	0.0196	0.0269
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0027	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0196	0.0269
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0035	0.0196	0.0269
Echinococcus granulosus	calpain 7 C02 family	0.0021	0.0042	0.0058
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0146	0.1427	0.1955
Schistosoma mansoni	chromatin regulatory protein sir2	0.0676	0.7299	1
Brugia malayi	hypothetical protein	0.0029	0.013	0.0178
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0146	0.1427	1
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0676	0.7299	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0035	0.0196	0.0269
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0146	0.1427	0.1955
Onchocerca volvulus		0.0034	0.0191	0.9759
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0035	0.0196	0.0269
Echinococcus granulosus	chromatin regulatory protein sir2	0.0676	0.7299	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0502	0.5373	0.7361
Echinococcus granulosus	calpain 5	0.0021	0.0042	0.0058
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0502	0.5373	0.7361
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0196	0.0269
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0027	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0035	0.0196	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0196	0.0269
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0027	0.0037
Brugia malayi	calpain family protein 1	0.0055	0.042	0.0576
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0502	0.5373	0.7361
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0016	0.0021
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0372	0.051
Echinococcus multilocularis	FTZ F1 alpha	0.0035	0.0196	0.0196
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0027	0.0037
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0035	0.0196	0.0269
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.0524	0.0718
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0027	0.0037
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0146	0.1427	0.1955
Trypanosoma brucei	SIR2-like protein 4, putative	0.0146	0.1427	0.1908
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0146	0.1427	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0027	0.0037
Brugia malayi	Nuclear hormone receptor-like 1	0.0323	0.3382	0.4634
Loa Loa (eye worm)	hypothetical protein	0.004	0.026	0.0357
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0306	0.3202	0.4387
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0027	0.0027
Schistosoma mansoni	calpain-7 (C02 family)	0.0021	0.0042	0.0058
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.042	0.0576
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0035	0.0196	0.0269
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0035	0.0196	0.0196
Loa Loa (eye worm)	transcriptional regulator	0.0146	0.1427	0.1955
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0676	0.7299	0.7299
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0035	0.0196	0.0269
Schistosoma mansoni	RAR-like nuclear receptor	0.0035	0.0196	0.0269
Leishmania major	cathepsin L-like protease	0.0064	0.0524	0.0718
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0027	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0196	0.0269
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0035	0.0196	0.0269
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0035	0.0196	0.0269
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0035	0.0196	0.0269
Schistosoma mansoni	thyroid hormone receptor	0.0187	0.1878	0.2574
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0676	0.7299	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0037
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0027	0.0037
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0027	0.0027
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0042	0.0058
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0146	0.1427	0.1427
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Schistosoma mansoni	thyroid hormone receptor	0.0187	0.1878	0.2574
Schistosoma mansoni	chromatin regulatory protein sir2	0.0146	0.1427	0.1955
Echinococcus multilocularis	calpain	0.0021	0.0042	0.0042
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0027	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0035	0.0196	0.0269
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0035	0.0196	0.0196
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0035	0.0196	0.0269
Brugia malayi	hypothetical protein	0.0018	0.0016	0.0021
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0027	0.0037
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.013	0.0912
Schistosoma mansoni	chromatin regulatory protein sir2	0.0676	0.7299	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0035	0.0196	0.0269
Echinococcus multilocularis	ecdysone induced protein 78C	0.0035	0.0196	0.0196
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0027	0.0037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0388	0.0388
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0027	0.0037
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0035	0.0196	0.0269
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0021	0.0042	0.0058
Echinococcus granulosus	calpain A	0.0057	0.0448	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0352	0.0482
Echinococcus multilocularis	calpain A	0.0057	0.0448	0.0448
Schistosoma mansoni	calpain-7 (C02 family)	0.0021	0.0042	0.0058
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0146	0.1427	0.1955
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0035	0.0196	0.0269
Toxoplasma gondii	histone deacetylase SIR2-like	0.0146	0.1427	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0035	0.0196	0.0269
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0146	0.1427	0.1908
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0027	0.0037
Leishmania major	cathepsin L-like protease	0.0064	0.0524	0.0718
Brugia malayi	calpain 7	0.0021	0.0042	0.0058
Toxoplasma gondii	histone deacetylase SIR2	0.0146	0.1427	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0042	0.0058
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0676	0.7299	0.7299
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0016	0.0021
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0146	0.1427	0.1427
Brugia malayi	PXA domain containing protein	0.0019	0.0027	0.0037
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0676	0.7299	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0146	0.1427	0.1955
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.1496	0.1496
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.013	0.0121
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0035	0.0196	0.0269
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0035	0.0196	0.0269
Schistosoma mansoni	calpain C (C02 family)	0.0021	0.0042	0.0058
Brugia malayi	nuclear receptor RXR	0.0018	0.0016	0.0021
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0042	0.0058
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0027	0.0037
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0035	0.0196	0.0269
Entamoeba histolytica	hypothetical protein	0.0019	0.0027	0.0037
Echinococcus granulosus	calpain	0.0021	0.0042	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0502	0.5373	0.7361
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0037
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0018	0.0016	0.0016
Brugia malayi	glutaminase DH11.1	0.0265	0.275	0.3767
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0146	0.1427	0.1955
Echinococcus granulosus	ecdysone induced protein 78C	0.0035	0.0196	0.0269
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0676	0.7299	1
Leishmania major	hypothetical protein, conserved	0.0029	0.013	0.0178
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0027	0.0037
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0388	0.0388
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0502	0.5373	0.7361
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0057	0.0448	0.0614
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0027	0.0037
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0042	0.0058
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0462	0.0633
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0027	0.0037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0524	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0016	0.0021
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0146	0.1427	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0021	0.0042	0.0058
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0146	0.1427	0.1955
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0035	0.0196	0.0269
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0027	0.0037
Onchocerca volvulus	Protein ultraspiracle homolog	0.0035	0.0196	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.013	0.0912
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0035	0.0196	0.0269
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0388	0.0532
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0042	0.0058
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0027	0.0037
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0042	0.0058
Mycobacterium ulcerans	glutaminase	0.0265	0.275	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0035	0.0196	0.0196
Brugia malayi	nuclear hormone receptor	0.0035	0.0196	0.0269
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0021	0.0042	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0304	0.318	0.4357
Loa Loa (eye worm)	calpain family protein 1	0.004	0.026	0.0357
Brugia malayi	hypothetical protein	0.0018	0.0018	0.0025
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0388	0.0532
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0021	0.0042	0.0058
Schistosoma mansoni	hypothetical protein	0.0152	0.1496	0.2049
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0388	0.0532
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0524	0.0718
Brugia malayi	PXA domain containing protein	0.0019	0.0027	0.0037
Entamoeba histolytica	hypothetical protein, conserved	0.0146	0.1427	0.1955
Schistosoma mansoni	calpain (C02 family)	0.0021	0.0042	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0035	0.0196	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0016	0.0021
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0057	0.0448	0.0614
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0027	0.0037
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.013	0.0178
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0502	0.5373	0.6719
Loa Loa (eye worm)	hypothetical protein	0.0357	0.3759	0.515
Loa Loa (eye worm)	steroid hormone receptor	0.0035	0.0196	0.0269
Brugia malayi	Steroid receptor seven-up type 2	0.0035	0.0196	0.0269
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0035	0.0196	0.0269
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0027	0.0037
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0027	0.0037
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0196	0.0269
Onchocerca volvulus	Bile acid receptor homolog	0.0035	0.0196	1
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0027	0.0037
Schistosoma mansoni	chromatin regulatory protein sir2	0.0146	0.1427	0.1955
Brugia malayi	hypothetical protein	0.0018	0.0016	0.0021
Plasmodium vivax	calpain, putative	0.0021	0.0042	0.0298
Schistosoma mansoni	glutaminase	0.0265	0.275	0.3767
Brugia malayi	nuclear receptor NHR-88	0.0035	0.0196	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0029	0.013	0.0178
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0676	0.7299	1
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0676	0.7299	1
Loa Loa (eye worm)	transcriptional regulator	0.0676	0.7299	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.013	0.0912
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0027	0.0037
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0027	0.0027
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0035	0.0196	0.0196
Plasmodium vivax	hypothetical protein, conserved	0.0146	0.1427	1
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0146	0.1427	0.1955
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0057	0.0448	0.0614
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0027	0.0037
Brugia malayi	steroid hormone receptor	0.0035	0.0196	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0027	0.0037
Giardia lamblia	Hypothetical protein	0.0676	0.7299	1
Loa Loa (eye worm)	glutaminase 2	0.0265	0.275	0.3767

Activities

Activity type	Activity value	Assay description	Source	Reference
Activation (binding)	= 18 %	Activation of human Thyroid hormone receptor beta 1 (hTRbeta1)	ChEMBL.	12109914
Activation (binding)	= 18 %	Activation of human Thyroid hormone receptor beta 1 (hTRbeta1)	ChEMBL.	12109914
Activation (binding)	= 35 %	Activation of human Thyroid hormone receptor alpha1 (hTRalpha1)	ChEMBL.	12109914
Activation (binding)	= 35 %	Activation of human Thyroid hormone receptor alpha1 (hTRalpha1)	ChEMBL.	12109914
IC50 (binding)	= 680 nM	Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)	ChEMBL.	12109914
IC50 (binding)	= 680 nM	Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)	ChEMBL.	12109914
IC50 (binding)	= 5000 nM	Half-maximum activation of human Thyroid hormone receptor alpha1 (hTRalpha1)	ChEMBL.	12109914
IC50 (binding)	= 5000 nM	Half-maximum activation of human Thyroid hormone receptor alpha1 (hTRalpha1)	ChEMBL.	12109914
Kd (binding)	= 35 nM	Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3	ChEMBL.	12109914
Kd (binding)	= 35 nM	Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3	ChEMBL.	12109914
Kd (functional)	= 35 nM	Antagonist activity at human TRbeta1	ChEMBL.	22512468
Kd (binding)	= 200 nM	Binding affinity against human Thyroid hormone receptor alpha1 (hTRalpha1) using radiolabeled T3	ChEMBL.	12109914
Kd (binding)	= 200 nM	Binding affinity against human Thyroid hormone receptor alpha1 (hTRalpha1) using radiolabeled T3	ChEMBL.	12109914
Kd (functional)	= 200 nM	Antagonist activity at human TRalpha1	ChEMBL.	22512468

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL112087
PubChem: 10321482

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 186754