TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 381.47 | Formula: C16H19N3O4S2
H donors: 1 H acceptors: 4 LogP: 1.37 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)Nc1scc(n1)c1ccc(cc1)S(=O)(=O)N1CCOCC1
InChi: 1S/C16H19N3O4S2/c1-2-15(20)18-16-17-14(11-24-16)12-3-5-13(6-4-12)25(21,22)19-7-9-23-10-8-19/h3-6,11H,2,7-10H2,1H3,(H,17,18,20)
InChiKey: WQTCBZWAGOITIP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fatty acid synthase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks4	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	KR domain domain-containing protein, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks3	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus		Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Soraphen polyketide synthase A, related	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	acyl carrier protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks12	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks2	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus	Fatty acid synthase homolog	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.2595	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0589	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0051	0.8635	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0589	0.1365
Onchocerca volvulus	Fatty acid synthase homolog	0.0054	0.9412	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0885	0.2052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.003	0.4328	0.4065
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0012	0.0589	0.1365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0589	0.0682
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0032	0.4721	0.481
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.4721	0.481
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.003	0.4314	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Entamoeba histolytica	hypothetical protein	0.003	0.4314	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.4328	0.4065
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0032	0.4721	0.481
Giardia lamblia	GTOR	0.0022	0.2595	0.5
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0028	0.3912	0.453
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Toxoplasma gondii	FATC domain-containing protein	0.003	0.4314	0.8938
Echinococcus multilocularis	serine protein kinase ATM	0.003	0.4314	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Onchocerca volvulus		0.0052	0.9019	0.9285
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Loa Loa (eye worm)	acyl carrier protein	0.0014	0.0906	0.105
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.2595	0.3006
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.2595	0.4458
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0022	0.2604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.4328	0.4065
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.2595	0.4987
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0032	0.4721	0.6242
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.4721	0.6242
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.2604	0.541
Mycobacterium ulcerans	thioesterase TesA	0.0025	0.3272	0.2064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0589	0.1365
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.003	0.4328	0.5702
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.2595	0.5386
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.2595	0.4987
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0017	0.1595	0.1953
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0025	0.3272	0.2064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0589	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0885	0.1025
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0032	0.4721	0.481
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.2595	0.5386
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0024	0.309	0.172
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0015	0.1195	0.0807
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0045	0.7461	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Loa Loa (eye worm)	fatty acid synthase	0.003	0.4244	0.4915
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.003	0.4314	0.4314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0022	0.2544	0.3255
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.2595	0.2595
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0045	0.7461	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0029	0.4134	0.5436
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0012	0.0555	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3429	0.3971
Toxoplasma gondii	type I fatty acid synthase, putative	0.0021	0.2503	0.4216
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.2595	0.6016
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.002	0.2103	0.3174
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.3912	0.3912
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0885	0.2052
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0032	0.4721	0.6242
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.003	0.4328	0.5702
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.2595	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.2595	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.003	0.4328	0.4065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.4328	0.4065
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0024	0.309	0.172
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0029	0.4134	0.5436
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0589	0.1365
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.2595	0.6016
Mycobacterium leprae	Polyketide synthase Pks13	0.0045	0.7461	1
Mycobacterium ulcerans	polyketide synthase	0.003	0.4328	0.4065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0589	0.1365
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.4314	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.2595	0.4987
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.003	0.4328	0.4328
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.003	0.4314	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0012	0.0589	0.1365
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.4328	0.5702
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.2595	0.4987
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0032	0.4721	0.481
Mycobacterium ulcerans	polyketide synthase Pks13	0.0045	0.7461	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.2595	0.4987
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.2595	0.6016
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.2595	0.3006
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.3429	0.7623
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0025	0.3174	0.4119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0012	0.0589	0.1365
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.2595	0.5386
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.003	0.4314	1
Toxoplasma gondii	type I fatty acid synthase, putative	0.0032	0.4721	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0024	0.309	0.172
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.2595	0.5386
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.2595	0.2595
Echinococcus granulosus	serine protein kinase ATM	0.003	0.4314	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0589	0.1365
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.4328	0.4065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Mycobacterium ulcerans	thioesterase	0.0025	0.3272	0.2064
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0028	0.3912	0.5131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.2595	0.6016
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0589	0.0589
Mycobacterium ulcerans	polyketide synthase	0.0032	0.4721	0.481
Loa Loa (eye worm)	hypothetical protein	0.0017	0.1543	0.1786
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0025	0.3272	0.4254

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	4.52 uM	PubChem BioAssay. SAR confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3183860

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1867695