Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.1766 | 0.1713 |
Brugia malayi | hypothetical protein | 0.0104 | 0.422 | 0.4451 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.4083 | 0.4307 |
Schistosoma mansoni | lamin | 0.0027 | 0.0606 | 0.0545 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.9481 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4083 | 0.4083 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.9481 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.095 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1713 | 0.1713 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.4083 | 0.4307 |
Schistosoma mansoni | lamin | 0.0027 | 0.0606 | 0.0545 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.1766 | 0.1766 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.1766 | 0.1713 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.4083 | 0.4045 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7498 | 0.7482 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4083 | 0.4083 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1713 | 0.1806 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0606 | 0.0545 |
Schistosoma mansoni | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.1766 | 0.1713 |
Echinococcus granulosus | lamin | 0.0027 | 0.0606 | 0.0545 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0225 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.9481 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1713 | 0.1713 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.4083 | 0.4045 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.4083 | 0.4045 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7498 | 0.7482 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0606 | 0.0545 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0606 | 0.0545 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0606 | 0.0639 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.9481 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.9481 | 0.9478 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.1766 | 0.1713 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.4083 | 0.4307 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1713 | 0.1806 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.4083 | 0.4045 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0225 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.9481 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0064 | 0.0064 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0606 | 0.0545 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0.4083 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0064 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0606 | 0.0606 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0101 | 0.4083 | 0.4083 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0225 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0606 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0064 | 0.0064 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.4083 | 1 |
Onchocerca volvulus | 0.0154 | 0.6611 | 1 | |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.1766 | 0.1863 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.4083 | 0.4307 |
Brugia malayi | hypothetical protein | 0.0154 | 0.6611 | 0.6972 |
Echinococcus granulosus | geminin | 0.0173 | 0.7498 | 0.7482 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0606 | 0.0545 |
Echinococcus multilocularis | geminin | 0.0173 | 0.7498 | 0.7482 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.095 | 0.0891 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0606 | 0.0639 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0606 | 0.0606 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0606 | 0.0545 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.1766 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.095 | 0.095 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.1766 | 0.1713 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.9481 | 0.9478 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4083 | 0.4083 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0064 | 0.0068 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.9481 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.9481 | 0.9481 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.9481 | 0.9481 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.9481 | 0.9478 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.9481 | 0.9478 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.6611 | 0.6611 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.4083 | 0.4307 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.8 nM | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | ChEMBL. | 12039560 |
Ki (binding) | = 9 nM | Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes | ChEMBL. | 12039560 |
Ki (binding) | = 48 nM | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | ChEMBL. | 12039560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.