Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0071 | 0.0525 | 0.0525 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0525 | 0.0525 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0333 | 0.4468 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0554 | 0.0554 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0554 | 0.0064 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0069 | 0.0493 | 0.0493 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0276 | 0.3607 | 0.3607 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.012 | 0.012 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0071 | 0.0525 | 0.0525 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.7516 | 0.7516 |
Schistosoma mansoni | lozenge | 0.0067 | 0.046 | 0.046 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0069 | 0.0493 | 0.0493 |
Schistosoma mansoni | lipoxygenase | 0.0147 | 0.1668 | 0.1668 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0071 | 0.0525 | 0.0525 |
Schistosoma mansoni | polycystin 1-related | 0.0071 | 0.0525 | 0.0525 |
Onchocerca volvulus | 0.0071 | 0.0525 | 0.0525 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.07 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0554 | 0.0554 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0554 | 0.0554 |
Echinococcus granulosus | RUN | 0.0071 | 0.0525 | 0.0525 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.3666 | 0.3666 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0181 | 0.0181 |
Echinococcus granulosus | thymidylate synthase | 0.07 | 1 | 1 |
Echinococcus multilocularis | RUN | 0.0071 | 0.0525 | 0.0525 |
Schistosoma mansoni | rab6-interacting | 0.0071 | 0.0525 | 0.0525 |
Loa Loa (eye worm) | doublecortin family protein | 0.0071 | 0.0525 | 0.0525 |
Brugia malayi | Doublecortin family protein | 0.0071 | 0.0525 | 0.0525 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0071 | 0.0525 | 0.0525 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0525 | 0.0525 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0069 | 0.0493 | 0.0493 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.07 | 1 | 1 |
Onchocerca volvulus | 0.0535 | 0.7516 | 0.7516 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0181 | 0.0181 |
Schistosoma mansoni | lipoxygenase | 0.0276 | 0.3607 | 0.3607 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.07 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.07 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0554 | 0.0064 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.07 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.07 | 1 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0069 | 0.0493 | 0.0493 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0071 | 0.0525 | 0.0525 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0554 | 0.0554 |
Onchocerca volvulus | 0.0071 | 0.0525 | 0.0525 | |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.3666 | 0.3666 |
Brugia malayi | hypothetical protein | 0.0535 | 0.7516 | 0.7516 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0065 | 0.0422 | 0.0422 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.7516 | 0.7516 |
Loa Loa (eye worm) | runx1 | 0.0067 | 0.046 | 0.046 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.012 | 0.012 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.07 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0554 | 0.0064 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0071 | 0.0525 | 0.0525 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0333 | 0.4468 | 0.4181 |
Schistosoma mansoni | rab6-interacting | 0.0071 | 0.0525 | 0.0525 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.012 | 0.012 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0276 | 0.3607 | 0.3607 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0554 | 0.0064 |
Brugia malayi | hypothetical protein | 0.0333 | 0.4468 | 0.4468 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0525 | 0.0525 |
Mycobacterium ulcerans | thymidylate synthase | 0.07 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.07 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.07 | 1 | 1 |
Onchocerca volvulus | 0.07 | 1 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.07 | 1 | 1 |
Schistosoma mansoni | loxhd1 | 0.0071 | 0.0525 | 0.0525 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0554 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0031 | 0.0031 |
Echinococcus multilocularis | Protein lozenge | 0.0067 | 0.046 | 0.046 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0525 | 0.0525 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.07 | 1 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0071 | 0.0525 | 0.0525 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 21.8724 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 30.6379 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 38.8952 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 38.8952 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 54.941 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 54.941 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 61.1306 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 61.6448 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.