Detailed information for compound 1868872

Basic information

Technical information
  • TDR Targets ID: 1868872
  • Name: 3,5,5-Trimethylhexanal
  • MW: 142.239 | Formula: C9H18O
  • H donors: 0 H acceptors: 1 LogP: 2.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CCC(CC(C)(C)C)C
  • InChi: 1S/C9H18O/c1-8(5-6-10)7-9(2,3)4/h6,8H,5,7H2,1-4H3
  • InChiKey: WTPYRCJDOZVZON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,5,5-Trimethylcapronaldehyde
  • 303550_ALDRICH
  • 4-01-00-03362 (Beilstein Handbook Reference)
  • 5435-64-3
  • AI3-22274
  • BRN 1740882
  • EINECS 226-603-0
  • FEMA No. 3524
  • Hexanal, 3,5,5-trimethl-
  • Hexanal, 3,5,5-trimethyl-
  • Isononylaldehyde
  • NSC 21482
  • NSC21482
  • tert-Butylisopentanal
  • W352403_ALDRICH

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0544 0.0354
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis tensin 0.0041 0.03 0.0105
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Onchocerca volvulus 0.0046 0.0544 0.1095
Echinococcus granulosus tyrosine kinase 0.0086 0.2533 0.2402
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0086 0.2533 0.2402
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0047 0.0591 0.0405
Brugia malayi Variant SH3 domain containing protein 0.0041 0.03 0.0104
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.3485 0.3382
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Schistosoma mansoni ephrin receptor 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0046 0.0544 0.0356
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1155 0.0976
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0046 0.0544 0.0356
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0544 0.0356
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0047 0.0591 0.0405
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica hypothetical protein 0.0072 0.1826 0.1675
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0046 0.0544 0.0354
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0086 0.2533 0.2402
Schistosoma mansoni tensin 0.0041 0.03 0.0105
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Schistosoma mansoni SH2A 0.0041 0.03 0.0105
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0544 0.0356
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/EGFR protein kinase 0.0046 0.0544 0.0354
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase shark 0.0086 0.2533 0.2402
Brugia malayi Presenilin-like protein At2g29900 0.0083 0.2376 0.2222
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0106 0.3485 0.3382
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.3182 0.3044
Loa Loa (eye worm) SH2 domain-containing protein 0.0041 0.03 0.0104
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) presenilin spe-4 0.0083 0.2376 0.2222
Entamoeba histolytica hypothetical protein 0.0072 0.1826 0.1675
Giardia lamblia Kinase, CMGC MAPK 0.0106 0.3485 1
Onchocerca volvulus 0.0046 0.0544 0.1095
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis natriuretic peptide receptor 1 0.0046 0.0544 0.0356
Onchocerca volvulus 0.0046 0.0544 0.1095
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Plasmodium vivax protein kinase, putative 0.0046 0.0544 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Echinococcus multilocularis tyrosine protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis SH2 motif 0.0041 0.03 0.0105
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0544 0.0356
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0046 0.0544 0.0356
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0046 0.0544 0.0354
Plasmodium vivax tyrosine kinase-like protein, putative 0.0046 0.0544 0.5
Echinococcus multilocularis protein kinase 0.0046 0.0544 0.0356
Brugia malayi C-terminal src kinase protein 1 0.0046 0.0544 0.0354
Toxoplasma gondii protein kinase domain-containing protein 0.0046 0.0544 0.1054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.1826 0.1675
Brugia malayi Receptor family ligand binding region containing protein 0.0046 0.0544 0.0354
Brugia malayi Protein kinase domain containing protein 0.0086 0.2533 0.2382
Brugia malayi SH2 domain containing protein 0.0041 0.03 0.0104
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Echinococcus granulosus mitogen activated protein kinase 3 0.0106 0.3485 0.3382
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Echinococcus granulosus epidermal growth factor receptor 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.3485 0.3382
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0041 0.03 0.0104
Brugia malayi SH2 domain containing protein 0.0041 0.03 0.0104
Echinococcus granulosus raf serine:threonine protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Schistosoma mansoni protein kinase 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.1826 0.1675
Entamoeba histolytica ankyrin repeat protein 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Echinococcus multilocularis SH2 motif 0.0041 0.03 0.0105
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi Variant SH3 domain containing protein 0.0041 0.03 0.0104
Echinococcus granulosus SH2 motif 0.0041 0.03 0.0105
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0041 0.03 0.0105
Echinococcus granulosus tyrosine protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica tyrosin kinase, putative 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.0544 0.0354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.062 0.0434
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni protein kinase 0.0046 0.0544 0.0356
Echinococcus granulosus retinal guanylyl cyclase 2 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Entamoeba histolytica ankyrin repeat protein 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.3485 0.3382
Brugia malayi Tyrosine-protein kinase PR2 0.0046 0.0544 0.0354
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0046 0.0544 0.0356
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0086 0.2533 0.2382
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0046 0.0544 0.1054
Loa Loa (eye worm) TK/FAK protein kinase 0.0046 0.0544 0.0354
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Schistosoma mansoni serine/threonine RGC 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis SHC transforming protein 3 0.0041 0.03 0.0105
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0237 0.9918 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0041 0.03 0.0104
Schistosoma mansoni protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0086 0.2533 0.2402
Loa Loa (eye worm) STAT protein 0.0041 0.03 0.0104
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis receptor type guanylyl cyclase 0.0046 0.0544 0.0356
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0047 0.0591 0.0405
Echinococcus granulosus integrin linked protein kinase 0.0046 0.0544 0.0356
Echinococcus granulosus retinal guanylyl cyclase 2 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Entamoeba histolytica receptor protein kinase, putative 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/ALK protein kinase 0.0046 0.0544 0.0354
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0086 0.2533 0.2402
Brugia malayi Protein kinase domain containing protein 0.0086 0.2533 0.2382
Schistosoma mansoni suppressor of cytokine signaling 0.0041 0.03 0.0105
Leishmania major hypothetical protein, conserved 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0041 0.03 0.0105
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0106 0.3485 0.3382
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus granulosus receptor type guanylyl cyclase 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0041 0.03 0.0105
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0041 0.03 0.0105
Echinococcus granulosus retinal guanylyl cyclase 2 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase csk 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Echinococcus granulosus activated cdc42 kinase 1 0.0046 0.0544 0.0356
Entamoeba histolytica presenilin 1 peptidase, putative 0.0237 0.9918 1
Schistosoma mansoni suppressor of cytokine signaling 0.0041 0.03 0.0105
Brugia malayi Variant SH3 domain containing protein 0.0041 0.03 0.0104
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.3182 0.3044
Loa Loa (eye worm) TK protein kinase 0.0046 0.0544 0.0354
Loa Loa (eye worm) hypothetical protein 0.0048 0.0672 0.0484
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.2822 0.2699
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Toxoplasma gondii protein kinase 0.0046 0.0544 0.1054
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Brugia malayi Tyrosine-protein kinase abl-1 0.0086 0.2533 0.2382
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0041 0.03 0.0105
Brugia malayi bone morphogenetic protein type 1 receptor 0.0046 0.0544 0.0354
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Schistosoma mansoni hypothetical protein 0.0046 0.0544 0.0356
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0046 0.0544 0.0354
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0041 0.03 0.0105
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.062 0.0434
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis TK family protein kinase 0.0046 0.0544 0.0356
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0046 0.0544 0.0354
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0041 0.03 0.0105
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Plasmodium falciparum protein kinase, putative 0.0047 0.0591 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0046 0.0544 0.0354
Echinococcus granulosus expressed conserved protein 0.0041 0.03 0.0105
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0041 0.03 0.0105
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Trypanosoma cruzi protein kinase, putative 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0106 0.3485 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0544 0.0356
Brugia malayi SH2 domain containing protein 0.0041 0.03 0.0104
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/CSK protein kinase 0.0046 0.0544 0.0354
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.2533 0.2402
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0106 0.3485 0.3382
Echinococcus granulosus SHC transforming protein 3 0.0041 0.03 0.0105
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0086 0.2533 0.2402
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.0544 0.0354
Schistosoma mansoni tensin-related 0.0041 0.03 0.0105
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0591 0.0405
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0544 0.0354
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0042 0.0346 0.0153
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) serine/threonine protein kinase 0.0046 0.0544 0.0354
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Brugia malayi STAT protein, DNA binding domain containing protein 0.0041 0.03 0.0104
Echinococcus granulosus tyrosine protein kinase HCK 0.0046 0.0544 0.0356
Echinococcus granulosus SH2 motif 0.0041 0.03 0.0105
Onchocerca volvulus 0.0046 0.0544 0.1095
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0046 0.0544 0.0354
Schistosoma mansoni tyrosine kinase 0.0086 0.2533 0.2402
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0041 0.03 0.0105
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0041 0.03 0.0105
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Plasmodium vivax tyrosine kinase-like protein, putative 0.0046 0.0544 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Onchocerca volvulus 0.0046 0.0544 0.1095
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase Lyn 0.0087 0.258 0.245
Brugia malayi Variant SH3 domain containing protein 0.0041 0.03 0.0104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.062 0.0434
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0046 0.0544 0.0356
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0237 0.9918 1
Entamoeba histolytica hypothetical protein 0.0072 0.1826 0.1675
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0046 0.0544 0.0354
Echinococcus granulosus NCK adaptor protein 0.0041 0.03 0.0105
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0086 0.2533 0.2402
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0041 0.03 0.0104
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0544 0.0354
Loa Loa (eye worm) TK protein kinase 0.0046 0.0544 0.0354
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase csk 0.0046 0.0544 0.0356
Entamoeba histolytica SH2 domain containing protein 0.0041 0.03 0.0105
Schistosoma mansoni hypothetical protein 0.0072 0.1826 0.1675
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.1826 0.1675
Brugia malayi SH2 domain containing protein 0.0041 0.03 0.0104
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0041 0.03 0.0104
Echinococcus multilocularis protein kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis protein tyrosine kinase, putative 0.0046 0.0544 0.0356
Brugia malayi SH2 domain containing protein 0.0086 0.2533 0.2382
Echinococcus multilocularis kinase suppressor of Ras 1 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0544 0.0354
Echinococcus multilocularis tyrosine protein kinase Abl 0.0086 0.2533 0.2402
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi Presenilin spe-4 0.0083 0.2376 0.2222
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Echinococcus granulosus protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni nck2/grb4 0.0041 0.03 0.0105
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.062 0.0434
Echinococcus multilocularis epidermal growth factor receptor 0.0046 0.0544 0.0356
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0046 0.0544 0.0356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.062 0.0434
Brugia malayi Furin-like cysteine rich region family protein 0.0046 0.0544 0.0354
Entamoeba histolytica tyrosin kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni tensin-related 0.0041 0.03 0.0105
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Schistosoma mansoni protein kinase 0.0046 0.0544 0.0356
Onchocerca volvulus 0.0046 0.0544 0.1095
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/ROR protein kinase 0.0046 0.0544 0.0354
Brugia malayi hypothetical protein 0.0046 0.0544 0.0354
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi SH2 domain containing protein 0.0086 0.2533 0.2382
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Brugia malayi hypothetical protein 0.0072 0.1826 0.1661
Schistosoma mansoni ephrin receptor 0.0046 0.0544 0.0356
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0237 0.9918 1
Onchocerca volvulus 0.0086 0.2533 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase csk 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Brugia malayi ephrin receptor 1 precursor 0.0046 0.0544 0.0354
Onchocerca volvulus Tyrosine kinase homolog 0.0046 0.0544 0.1095
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0041 0.03 0.0104
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Trypanosoma cruzi protein kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.3182 0.3044
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Brugia malayi MAP kinase sur-1 0.0106 0.3485 0.3354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/RYK protein kinase 0.0046 0.0544 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK protein kinase 0.0046 0.0544 0.0354
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0047 0.0591 0.1196
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0046 0.0544 0.0356
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/DDR protein kinase 0.0046 0.0544 0.0354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.062 0.0434
Leishmania major protein kinase, putative 0.0047 0.0591 0.0405
Brugia malayi Presenilin family protein 0.0237 0.9918 0.9917
Trichomonas vaginalis protein kinase atn1, putative 0.0046 0.0544 0.0356
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine kinase 0.0086 0.2533 0.2402
Echinococcus granulosus hypothetical protein 0.0041 0.03 0.0105
Schistosoma mansoni protein kinase 0.0047 0.0591 0.0405
Schistosoma mansoni protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase pr2 0.0046 0.0544 0.0356
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0544 0.0356
Brugia malayi SRC-1 0.0086 0.2533 0.2382
Echinococcus granulosus tyrosine kinase 0.0086 0.2533 0.2402
Brugia malayi Protein kinase domain containing protein 0.0086 0.2533 0.2382
Loa Loa (eye worm) SRC-1 0.0086 0.2533 0.2382
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0041 0.03 0.0105
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis transfer RNA-Thr 0.0046 0.0544 0.0356
Schistosoma mansoni shc transforming protein 0.0041 0.03 0.0105
Echinococcus granulosus insulin receptor 0.0046 0.0544 0.0356
Echinococcus granulosus fibroblast growth factor receptor 4 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.2533 0.2402
Entamoeba histolytica tyrosin kinase, putative 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Onchocerca volvulus 0.0086 0.2533 1
Loa Loa (eye worm) TK protein kinase 0.0046 0.0544 0.0354
Echinococcus multilocularis signal transduction protein lnk realted 0.0041 0.03 0.0105
Schistosoma mansoni hypothetical protein 0.0068 0.1641 0.1484
Loa Loa (eye worm) TK/Met protein kinase 0.0046 0.0544 0.0354
Echinococcus granulosus epidermal growth factor receptor 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0046 0.0544 0.0356
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0046 0.0544 0.0354
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0041 0.03 0.0105
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0086 0.2533 0.2402
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0041 0.03 0.0105
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0544 0.0354
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0047 0.0591 0.0405
Echinococcus granulosus N chimaerin 0.0041 0.03 0.0105
Echinococcus multilocularis presenilin 0.0237 0.9918 1
Brugia malayi Raf kinase 0.0046 0.0544 0.0354
Echinococcus granulosus tyrosine protein kinase Src64B 0.0086 0.2533 0.2402
Echinococcus granulosus activin receptor type 0.0047 0.0591 0.0405
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0198 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0046 0.0544 0.0356
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.3485 0.3382
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.062 0.0434
Echinococcus multilocularis tyrosine protein kinase Srms 0.0086 0.2533 0.2402
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0237 0.9918 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0086 0.2533 0.2402
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis mitogen activated protein kinase 3 0.0106 0.3485 0.3382
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0228 0.0031
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis protein tyrosine kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0237 0.9918 1
Trichomonas vaginalis STE family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0046 0.0544 0.1054
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0086 0.2533 0.2402
Schistosoma mansoni protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis N chimaerin 0.0041 0.03 0.0105
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0086 0.2533 0.2402
Schistosoma mansoni tyrosine kinase 0.0086 0.2533 0.2402
Echinococcus multilocularis activated cdc42 kinase 1 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase ABL1 0.0086 0.2533 0.2402
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.03 0.0105
Schistosoma mansoni jumonji domain containing protein 0.0073 0.1895 0.1746
Echinococcus granulosus kinase suppressor of Ras 1 0.0046 0.0544 0.0356
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0086 0.2533 0.2382
Echinococcus granulosus tyrosine protein kinase Src42A 0.0086 0.2533 0.2402
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK protein kinase 0.0046 0.0544 0.0354
Entamoeba histolytica hypothetical protein 0.0072 0.1826 0.1675
Schistosoma mansoni signal transduction protein lnk-related 0.0041 0.03 0.0105
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0106 0.3485 0.3382
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0046 0.0544 0.0354
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.3485 0.3382
Echinococcus granulosus tensin 0.0041 0.03 0.0105
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0086 0.2533 0.2402
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase HCK 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0068 0.1641 0.1472
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0041 0.03 0.0105
Echinococcus multilocularis tyrosine protein kinase csk 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis integrin linked protein kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni protein tyrosine kinase 0.0046 0.0544 0.0356
Onchocerca volvulus 0.0086 0.2533 1
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.0544 0.0354
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0041 0.03 0.0105
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0046 0.0544 0.1095
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0046 0.0544 0.0356
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0106 0.3485 0.3382
Onchocerca volvulus 0.0086 0.2533 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0041 0.03 0.0105
Brugia malayi hypothetical protein 0.0083 0.2376 0.2222
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis SH2 domain containing protein 7 0.0041 0.03 0.0105
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1641 0.1472
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0041 0.03 0.0104
Echinococcus multilocularis 0.0041 0.03 0.0105
Echinococcus multilocularis tyrosine protein kinase Blk 0.0086 0.2533 0.2402
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0046 0.0544 0.0356
Echinococcus granulosus mitogen activated protein kinase 0.0106 0.3485 0.3382
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0046 0.0544 0.0354
Toxoplasma gondii STE kinase 0.0046 0.0544 0.1054
Echinococcus multilocularis protein KINase family member (kin 25) 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0046 0.0544 0.0356
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0237 0.9918 1
Brugia malayi Tensin 0.0041 0.03 0.0104
Brugia malayi SH2 domain containing protein 0.0041 0.03 0.0104
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.0544 0.0356
Loa Loa (eye worm) protein kinase domain-containing protein 0.0046 0.0544 0.0354
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.062 0.043
Echinococcus multilocularis activin receptor type 0.0047 0.0591 0.0405
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0086 0.2533 0.2402
Echinococcus granulosus signal transduction protein lnk realted 0.0041 0.03 0.0105
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0047 0.0591 0.0405
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Brugia malayi RhoGAP domain containing protein 0.0041 0.03 0.0104
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0086 0.2533 0.2402
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase pr2 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Schistosoma mansoni vav2 0.0041 0.03 0.0105
Loa Loa (eye worm) SH2 domain-containing protein 0.0041 0.03 0.0104
Trypanosoma brucei protein kinase, putative 0.0106 0.3485 0.3382
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Leishmania major protein kinase, putative 0.0046 0.0544 0.0356
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Onchocerca volvulus 0.0086 0.2533 1
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase csk 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis FL cytokine receptor 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0042 0.0346 0.0153
Brugia malayi Presenilin spe-4 0.0083 0.2376 0.2222
Brugia malayi tRNA modification GTPase TrmE family protein 0.0041 0.03 0.0104
Loa Loa (eye worm) TK/EPH protein kinase 0.0046 0.0544 0.0354
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0046 0.0544 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0544 0.0356
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Loa Loa (eye worm) TK/ABL protein kinase 0.0086 0.2533 0.2382
Loa Loa (eye worm) TK/ACK protein kinase 0.0046 0.0544 0.0354
Echinococcus multilocularis heat shock protein 70 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.2533 0.2402
Schistosoma mansoni growth factor receptor-bound protein 0.0041 0.03 0.0105
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Echinococcus multilocularis epidermal growth factor receptor 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0086 0.2533 0.2382
Brugia malayi cytokine inducible SH2-containing protein 5 0.0041 0.03 0.0104
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0046 0.0544 0.0356
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0544 0.0356
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine kinase 0.0046 0.0544 0.0356
Brugia malayi integrin-linked kinase 0.0046 0.0544 0.0354
Brugia malayi protein-tyrosine kinase 0.0086 0.2533 0.2382
Onchocerca volvulus 0.0046 0.0544 0.1095
Echinococcus multilocularis tensin 0.0041 0.03 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase Fyn 0.0086 0.2533 0.2402
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.062 0.043
Echinococcus granulosus tyrosine protein kinase Fyn 0.0086 0.2533 0.2402
Echinococcus granulosus suppressor of cytokine signaling 7 0.0041 0.03 0.0105
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Echinococcus granulosus tyrosine protein kinase Srms 0.0086 0.2533 0.2402
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0544 0.0354
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase csk 0.0046 0.0544 0.0356
Echinococcus multilocularis SH2 motif 0.0041 0.03 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.0544 0.0354
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Echinococcus granulosus SH2 domain containing adapter protein F 0.0041 0.03 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0046 0.0544 0.0356
Brugia malayi SH2 domain containing protein 0.0041 0.03 0.0104
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0086 0.2533 0.2402
Entamoeba histolytica receptor protein kinase, putative 0.0046 0.0544 0.0356
Echinococcus granulosus growth factor receptor bound protein 2 0.0041 0.03 0.0105
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Onchocerca volvulus 0.0046 0.0544 0.1095
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.3485 0.3382
Echinococcus multilocularis growth factor receptor bound protein 2 0.0041 0.03 0.0105
Brugia malayi jmjC domain containing protein 0.0092 0.2822 0.2677
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0046 0.0544 0.0356
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase Fyn 0.0086 0.2533 0.2402
Brugia malayi Sex muscle abnormal protein 5 0.0041 0.03 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0544 0.0356
Trypanosoma brucei protein kinase, putative 0.0047 0.0591 0.0405
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0086 0.2533 0.2402
Schistosoma mansoni hypothetical protein 0.0041 0.03 0.0105
Entamoeba histolytica tyrosin kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni protein kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus granulosus presenilin 0.0237 0.9918 1
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0106 0.3485 0.3354
Schistosoma mansoni protein kinase 0.0047 0.0591 0.0405
Echinococcus multilocularis NCK adaptor protein 0.0041 0.03 0.0105
Trypanosoma brucei Pseudokinase, putative 0.0046 0.0544 0.0356
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0228 0.0031
Schistosoma mansoni protein kinase 0.0047 0.0591 0.0405
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.2533 0.2402
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0086 0.2533 0.2402
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni GTPase activating protein 0.0041 0.03 0.0105
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0544 0.0354
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0086 0.2533 0.2402
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase shark 0.0086 0.2533 0.2402
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0041 0.03 0.0105
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0046 0.0544 0.1095
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK protein kinase 0.0046 0.0544 0.0354
Brugia malayi hypothetical protein 0.0083 0.2376 0.2222
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni hypothetical protein 0.0041 0.03 0.0105
Loa Loa (eye worm) hypothetical protein 0.01 0.3182 0.3044
Brugia malayi Guanylyl cyclase protein 23 0.0046 0.0544 0.0354
Loa Loa (eye worm) TK protein kinase 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine kinase 0.0046 0.0544 0.0356
Entamoeba histolytica hypothetical protein, conserved 0.0046 0.0544 0.0356
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.2822 0.2699
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi SH2 domain containing protein 0.0041 0.03 0.0104
Brugia malayi hypothetical protein 0.0046 0.0544 0.0354
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase Blk 0.0086 0.2533 0.2402
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0544 0.0354
Echinococcus multilocularis c src tyrosine kinase 0.0086 0.2533 0.2402
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.3485 0.3382
Loa Loa (eye worm) TK protein kinase 0.0046 0.0544 0.0354
Schistosoma mansoni protein kinase 0.0046 0.0544 0.0356
Echinococcus granulosus suppressor of cytokine signaling 6 0.0041 0.03 0.0105
Echinococcus granulosus ephrin type A receptor 4 A 0.0046 0.0544 0.0356
Echinococcus granulosus natriuretic peptide receptor 1 0.0046 0.0544 0.0356
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0046 0.0544 0.0356
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0046 0.0544 0.0354
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Brugia malayi Protein kinase domain containing protein 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus granulosus c src tyrosine kinase 0.0086 0.2533 0.2402
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0237 0.9918 1
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Entamoeba histolytica cysteine surface protein, putative 0.0046 0.0544 0.0356
Toxoplasma gondii hypothetical protein 0.0083 0.2376 0.6626
Loa Loa (eye worm) SH2 domain-containing protein 0.0041 0.03 0.0104
Echinococcus multilocularis mitogen activated protein kinase 0.0106 0.3485 0.3382
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Onchocerca volvulus 0.0046 0.0544 0.1095
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0086 0.2533 0.2402
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni growth factor receptor-bound protein 0.0041 0.03 0.0105
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Echinococcus multilocularis insulin receptor 0.0046 0.0544 0.0356
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0041 0.03 0.0104
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus granulosus activated cdc42 kinase 1 0.0046 0.0544 0.0356
Schistosoma mansoni tensin 0.0041 0.03 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.03 0.0105
Loa Loa (eye worm) TK protein kinase 0.0046 0.0544 0.0354
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0198 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus granulosus SH2 domain containing protein 7 0.0041 0.03 0.0105
Schistosoma mansoni tensin 0.0041 0.03 0.0105
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.0544 0.0354
Loa Loa (eye worm) hypothetical protein 0.0046 0.0544 0.0354
Loa Loa (eye worm) TK/FER protein kinase 0.0086 0.2533 0.2382
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0237 0.9918 1
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase csk 0.0046 0.0544 0.0356
Schistosoma mansoni tyrosine kinase 0.0086 0.2533 0.2402
Entamoeba histolytica hypothetical protein 0.0046 0.0544 0.0356
Brugia malayi hypothetical protein 0.0083 0.2376 0.2222
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0046 0.0544 0.0356
Entamoeba histolytica protein kinase, putative 0.0046 0.0544 0.0356
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0086 0.2533 0.2402
Schistosoma mansoni adapter molecule crk 0.0041 0.03 0.0105
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0544 0.0356
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.0544 0.0356
Brugia malayi hypothetical protein 0.0086 0.2533 0.2382
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0544 0.0356
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0544 0.0356
Brugia malayi hypothetical protein 0.0041 0.03 0.0104
Brugia malayi Presenilin spe-4 0.0083 0.2376 0.2222
Loa Loa (eye worm) TK protein kinase 0.0086 0.2533 0.2382
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0104
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0046 0.0544 0.0354
Echinococcus granulosus protein tyrosine kinase 0.0046 0.0544 0.0356
Onchocerca volvulus 0.0086 0.2533 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0041 0.03 0.0105

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 76.9588 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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