TDR Targets

Basic information

Technical information

TDR Targets ID: 18692
Name: 2-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[( 2S,5R)-5-bromo-2,6,6-trimethyloxan-2-yl]-8a-m ethyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[3,2-b] pyran-2-yl]-1,4-dihydroxypentyl]-5-methyloxol an-2-yl]propan-2-yl acetate
MW: 647.678 | Formula: C32H55BrO8
H donors: 2 H acceptors: 3 LogP: 4.22 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: O[C@H]([C@@]1(C)CC[C@@H](O1)C(OC(=O)C)(C)C)CC[C@@]([C@H]1CC[C@@H]2[C@](O1)(C)CC[C@@H](O2)[C@]1(C)CC[C@H](C(O1)(C)C)Br)(O)C
InChi: 1S/C32H55BrO8/c1-20(34)38-28(4,5)23-14-18-30(7,39-23)22(35)13-16-29(6,36)24-10-11-25-31(8,40-24)19-15-26(37-25)32(9)17-12-21(33)27(2,3)41-32/h21-26,35-36H,10-19H2,1-9H3/t21-,22+,23-,24-,25-,26-,29+,30-,31+,32+/m1/s1
InChiKey: CFIPFJIKZAGWFH-WMYXADBDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[1-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydropyran-2-yl]-8a-methyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[3,2-b]pyran-2-yl]-1,4-dihydroxy-pentyl]-5-methyl-tetrahydrofuran-2-yl]-1-methyl-ethyl] acetate
acetic acid [1-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyl-2-tetrahydropyranyl]-8a-methyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[3,2-b]pyran-2-yl]-1,4-dihydroxypentyl]-5-methyl-2-tetrahydrofuranyl]-1-methylethyl] ester
2-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyl-oxan-2-yl]-8a-methyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[3,2-b]pyran-2-yl]-1,4-dihydroxy-pentyl]-5-methyl-oxolan-2-yl]propan-2-yl ethanoate
acetic acid [1-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydropyran-2-yl]-8a-methyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[3,2-b]pyran-2-yl]-1,4-dihydroxy-pentyl]-5-methyl-tetrahydrofuran-2-yl]-1-methyl-ethyl] ester
thyrsiferyl 23-acetate
2-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyloxan-2-yl]-8a-methyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[5,6-b]pyran-2-yl]-1,4-dihydroxypentyl]-5-methyloxolan-2-yl]propan-2-yl acetate
[1-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydropyran-2-yl]-8a-methyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[5,6-b]pyran-2-yl]-1,4-dihydroxy-pentyl]-5-methyl-tetrahydrofuran-2-yl]-1-methyl-ethyl] acetate
acetic acid [1-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyl-2-tetrahydropyranyl]-8a-methyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[5,6-b]pyran-2-yl]-1,4-dihydroxypentyl]-5-methyl-2-tetrahydrofuranyl]-1-methylethyl] ester
acetic acid [1-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydropyran-2-yl]-8a-methyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[5,6-b]pyran-2-yl]-1,4-dihydroxy-pentyl]-5-methyl-tetrahydrofuran-2-yl]-1-methyl-ethyl] ester
2-[(2R,5R)-5-[(1S,4S)-4-[(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyl-oxan-2-yl]-8a-methyl-3,4,4a,6,7,8-hexahydro-2H-pyrano[5,6-b]pyran-2-yl]-1,4-dihydroxy-pentyl]-5-methyl-oxolan-2-yl]propan-2-yl ethanoate
96304-95-9
TF23A
TF-23A
(2S-(2alpha(R*(S*(2S*,5S*))),4abeta,6alpha(2S*,5R*),8aalpha))-alpha5-(3-(6-(5-Bromotetrahydro-2,6,6-trimethyl-2H-pyran-2-yl)octahydro-8a-methylpyrano(3,2-b)pyran-2-yl)-3-hydroxybutyl)tetrahydro alpha2,alpha2,5-trimethyl-2,5-furandimethanol alpha2-acetate
2,5-Furandimethanol, alpha5-(3-(6-(5-bromotetrahydro-2,6,6-trimethyl-2H-pyran-2-yl)octahydro-8a-methylpyrano(3,2-b)pyran-2-yl)-3-hydroxybutyl)tetrahydro alpha2,alpha2,5-trimethyl-, alpha2-acetate, (2S-(2alpha(R*(S*(2S*,5S*))),4abeta,6alpha(2S*,5R*),8aalpha))-

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Gallus gallus	Serine-threonine protein phosphatase 2A regulatory subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Echinococcus multilocularis	protein phosphatase pp2a regulatory subunit b	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania major	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Trypanosoma congolense	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Entamoeba histolytica	protein phosphatase regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Trichomonas vaginalis	protein phosphatase pp2a regulatory subunit B, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Trichomonas vaginalis	protein phosphatase PP2A regulatory subunit B, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania donovani	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Trypanosoma congolense	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Onchocerca volvulus	Protein phosphatase PP2A 55 kDa regulatory subunit homolog	Get druggable targets OG5_126981	All targets in OG5_126981
Brugia malayi	serine/threonine protein phosphatase 2A	Get druggable targets OG5_126981	All targets in OG5_126981
Schistosoma mansoni	protein phosphatase pp2a regulatory subunit B	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania mexicana	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Trypanosoma cruzi	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Giardia lamblia	Protein phosphatase PP2A regulatory subunit B	Get druggable targets OG5_126981	All targets in OG5_126981
Trypanosoma brucei gambiense	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania braziliensis	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Trichomonas vaginalis	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Candida albicans	subunit of protein phosphatase 2A	Get druggable targets OG5_126981	All targets in OG5_126981
Echinococcus granulosus	protein phosphatase pp2a regulatory subunit b	Get druggable targets OG5_126981	All targets in OG5_126981
Schistosoma japonicum	similar to Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Trypanosoma cruzi	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania donovani	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Leishmania infantum	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981
Candida albicans	subunit of protein phosphatase 2A	Get druggable targets OG5_126981	All targets in OG5_126981
Loa Loa (eye worm)	serine/threonine protein phosphatase 2A	Get druggable targets OG5_126981	All targets in OG5_126981
Trypanosoma brucei	hypothetical protein, conserved	Get druggable targets OG5_126981	All targets in OG5_126981
Trypanosoma brucei	protein phosphatase 2A regulatory subunit, putative	Get druggable targets OG5_126981	All targets in OG5_126981

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	similar to Protein phosphatase PP2A 55 kDa regulatory subunit, putative	Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	353 aa	37.4 %
Dictyostelium discoideum	hypothetical protein	Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	366 aa	31.7 %
Schistosoma japonicum	ko:K01530 phospholipid-translocating ATPase [EC3.6.3.1], putative	Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	468 aa	45.7 %
Echinococcus granulosus	cleavage stimulation factor subunit 1	Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	364 aa	19.5 %
Onchocerca volvulus		Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	444 aa	65.5 %
Schistosoma mansoni	protein phosphatase 2a regulatory subunit	Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	350 aa	38.9 %
Brugia malayi	Protein kinase domain containing protein	Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	474 aa	20.5 %
Echinococcus multilocularis	cleavage stimulation factor subunit 1	Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	364 aa	19.5 %
Onchocerca volvulus		Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	355 aa	22.5 %
Schistosoma mansoni	protein phosphatase pp2a regulatory subunit B	Serine-threonine protein phosphatase 2A regulatory subunit	426 aa	350 aa	38.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	opsin-like receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.1004	0.1004
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.1004	0.1004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Onchocerca volvulus		0.0025	0.1004	0.1381
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.1004	0.1004
Echinococcus granulosus	proteasome prosome macropain	0.0071	0.4953	0.4953
Trichomonas vaginalis	protein phosphatase PP2A regulatory subunit B, putative	0.0074	0.5177	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.1053	0.2035
Onchocerca volvulus		0.0025	0.1004	0.1381
Onchocerca volvulus	Protein phosphatase PP2A 55 kDa regulatory subunit homolog	0.0074	0.5177	1
Brugia malayi	Cathepsin L-like precursor	0.0025	0.1053	0.2035
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.1004	0.1875
Trichomonas vaginalis	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative	0.0074	0.5177	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.1053	0.2035
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.1004	0.1004
Mycobacterium ulcerans	proteasome PrcB	0.0071	0.4953	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.1053	0.2035
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.1004	0.1004
Brugia malayi	Serotonin receptor	0.0025	0.1004	0.1939
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Plasmodium vivax	multidomain scavenger receptor, putative	0.0022	0.074	0.1493
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	sex peptide receptor	0.0025	0.1004	0.1004
Brugia malayi	putative neuropeptide receptor	0.0025	0.1004	0.1939
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.1004	0.1004
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0071	0.4953	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	hypothetical protein	0.0022	0.074	0.1429
Echinococcus multilocularis	protein phosphatase pp2a regulatory subunit b	0.0074	0.5177	0.5177
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	cathepsin l1	0.0025	0.1053	0.1053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0025	0.1004	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Trichomonas vaginalis	protein phosphatase pp2a regulatory subunit B, putative	0.0074	0.5177	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0041	0.0078
Schistosoma mansoni	biogenic amine receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0022	0.074	0.1361
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.1004	0.1004
Schistosoma mansoni	lipoxygenase	0.013	1	1
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0041	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.1004	0.1875
Leishmania major	cathepsin L-like protease	0.0025	0.1053	0.1972
Schistosoma mansoni	neuropeptide receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.1053	0.1053
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0025	0.1004	0.1381
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.1053	0.1483
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.1053	0.2035
Echinococcus multilocularis	cathepsin L cysteine protease	0.0025	0.1053	0.1053
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0071	0.4953	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.1004	0.1004
Schistosoma mansoni	amine GPCR	0.0025	0.1004	0.1004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0071	0.4953	0.5
Leishmania major	cathepsin L-like protease	0.0025	0.1053	0.1972
Brugia malayi	Serotonin receptor	0.0025	0.1004	0.1939
Echinococcus granulosus	serotonin receptor	0.0025	0.1004	0.1004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.1053	0.2035
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.1004	0.1004
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0335	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.1053	0.2035
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Onchocerca volvulus		0.0025	0.1004	0.1381
Echinococcus granulosus	g protein coupled receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.5177	1
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.1004	0.1004
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0025	0.1004	0.1939
Schistosoma mansoni	opsin-like receptor	0.0025	0.1004	0.1004
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0071	0.4953	0.9568
Echinococcus granulosus	protein phosphatase pp2a regulatory subunit b	0.0074	0.5177	0.5177
Brugia malayi	Cathepsin L-like precursor	0.0025	0.1053	0.2035
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0025	0.1004	0.1939
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.1004	0.1004
Leishmania major	protein phosphatase 2A regulatory subunit, putative	0.0074	0.5177	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.1004	0.1875
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.1004	0.1875
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0025	0.1053	0.1972
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Schistosoma mansoni	neuropeptide receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	rab6-interacting	0.0022	0.074	0.074
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Brugia malayi	Melatonin receptor type 1A	0.0025	0.1004	0.1939
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.1053	0.1483
Leishmania major	cathepsin L-like protease	0.0025	0.1053	0.1972
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0071	0.4953	0.9564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.1053	0.2035
Schistosoma mansoni	amine GPCR	0.0025	0.1004	0.1004
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0025	0.1053	0.2127
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.1004	0.1004
Trypanosoma cruzi	protein phosphatase 2A regulatory subunit, putative	0.0074	0.5177	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	serine/threonine protein phosphatase 2A	0.0074	0.5177	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.1004	0.1004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Loa Loa (eye worm)	serine/threonine protein phosphatase 2A	0.0074	0.5177	1
Brugia malayi	larval opioid receptor	0.0025	0.1004	0.1939
Schistosoma mansoni	protein phosphatase pp2a regulatory subunit B	0.0074	0.5177	0.5177
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Echinococcus multilocularis	serotonin receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0022	0.074	0.0835
Schistosoma mansoni	opsin-like receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	cysteine protease	0.0025	0.1053	0.1972
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.1004	0.1004
Echinococcus granulosus	neuropeptide receptor	0.0025	0.1004	0.1004
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.1004	0.1004
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	polycystin 1-related	0.0022	0.074	0.074
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.1004	0.1004
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.1004	0.1004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0071	0.4953	0.9568
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	orexin receptor type 2	0.0025	0.1004	0.1004
Brugia malayi	AKH receptor	0.0025	0.1004	0.1939
Echinococcus granulosus	g protein coupled receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0025	0.1004	0.1939
Onchocerca volvulus		0.0025	0.1004	0.1381
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.1004	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0025	0.1053	0.1483
Brugia malayi	Cathepsin L-like precursor	0.0025	0.1053	0.2035
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.1004	0.1004
Leishmania major	proteasome beta 5 subunit, putative	0.0071	0.4953	0.9564
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Giardia lamblia	Protein phosphatase PP2A regulatory subunit B	0.0074	0.5177	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0025	0.1053	0.1053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0335	0.0647
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0025	0.1004	0.1939
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.1004	0.1004
Leishmania major	cathepsin L-like protease	0.0025	0.1053	0.1972
Brugia malayi	G-protein coupled receptor	0.0025	0.1004	0.1939
Toxoplasma gondii	proteasome subunit beta type, putative	0.0071	0.4953	1
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.074	0.074
Brugia malayi	Doublecortin family protein	0.0022	0.074	0.1429
Entamoeba histolytica	cysteine protease, putative	0.0025	0.1053	0.2035
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0071	0.4953	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	somatostatin receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	cathepsin L cysteine protease	0.0025	0.1053	0.1053
Brugia malayi	Dopamine receptor protein 2	0.0025	0.1004	0.1939
Onchocerca volvulus		0.0025	0.1004	0.1381
Plasmodium vivax	vivapain-2	0.0025	0.1053	0.2127
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.5177	1
Echinococcus granulosus	neuropeptide receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.1004	0.1004
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0041	0.0078
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.1004	0.1004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.1053	0.2035
Brugia malayi	GnHR receptor homolog	0.0025	0.1004	0.1939
Schistosoma mansoni	hypothetical protein	0.0025	0.1004	0.1004
Echinococcus granulosus	hypothetical protein	0.0025	0.1004	0.1004
Brugia malayi	cathepsin L-like precursor	0.0017	0.0335	0.0647
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.1053	0.2035
Brugia malayi	follicle stimulating hormone receptor	0.0025	0.1004	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0025	0.1004	0.1939
Echinococcus multilocularis	somatostatin receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	adenoreceptor	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0022	0.074	0.0835
Trypanosoma cruzi	protein phosphatase 2A regulatory subunit, putative	0.0074	0.5177	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.1053	0.2035
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.1004	0.1004
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	amine GPCR	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.1004	0.1004
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.1004	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0025	0.1004	0.1939
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.074	0.074
Onchocerca volvulus		0.0025	0.1004	0.1381
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Leishmania major	cathepsin L-like protease	0.0025	0.1053	0.1972
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0025	0.1053	0.1053
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.1004	0.1004
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0025	0.1004	0.1381
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.1004	0.1004
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.1004	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Plasmodium vivax	vivapain-2	0.0025	0.1053	0.2127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.1004	0.1004
Brugia malayi	Proteasome A-type and B-type family protein	0.0071	0.4953	0.9568
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.1004	0.1004
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0335	0.0647
Onchocerca volvulus		0.0025	0.1053	0.1483
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	G protein-coupled receptor	0.0025	0.1004	0.1939
Leishmania major	hypothetical protein, conserved	0.0074	0.5177	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	hypothetical protein	0.0025	0.1004	0.1004
Schistosoma mansoni	amine GPCR	0.0025	0.1004	0.1004
Echinococcus granulosus	allatostatin A receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0025	0.1004	0.1381
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.1004	0.1004
Schistosoma mansoni	lipoxygenase	0.0091	0.6654	0.6654
Brugia malayi	Dopamine receptor protein 1	0.0025	0.1004	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Plasmodium falciparum	LCCL domain-containing protein	0.0022	0.074	0.1493
Plasmodium falciparum	proteasome subunit beta type-5	0.0071	0.4953	1
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0041	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Loa Loa (eye worm)	ctsf protein	0.0025	0.1053	0.1972
Echinococcus multilocularis	serotonin receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.1004	0.1004
Echinococcus granulosus	Polycystic kidney disease protein	0.0022	0.074	0.074
Onchocerca volvulus		0.0025	0.1004	0.1381
Onchocerca volvulus		0.0025	0.1053	0.1483
Trypanosoma cruzi	cruzipain precursor, putative	0.0025	0.1053	0.2035
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.1004	0.1004
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.1004	0.1004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.1053	0.2035
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	Polycystic kidney disease protein	0.0022	0.074	0.074
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.1053	0.2035
Schistosoma mansoni	myosin xvIII	0.0025	0.1004	0.1004
Schistosoma mansoni	hypothetical protein	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	G-protein coupled receptor	0.0025	0.1004	0.1939
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.013	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.1053	0.2035
Leishmania major	cysteine peptidase A (CPA)	0.0025	0.1053	0.1972
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0574
Loa Loa (eye worm)	fibroinase	0.0025	0.1053	0.1972
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0335	0.0647
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0071	0.4953	0.9568
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Schistosoma mansoni	hypothetical protein	0.0022	0.074	0.074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0025	0.1004	0.1381
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0025	0.1053	0.1483
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.1053	0.2035
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.1004	0.1004
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Brugia malayi	putative neuropeptide receptor NPR1	0.0025	0.1004	0.1939
Brugia malayi	Cathepsin L-like precursor	0.0025	0.1053	0.2035
Loa Loa (eye worm)	hypothetical protein	0.0022	0.074	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.1053	0.2035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.5177	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.1004	0.1875
Onchocerca volvulus		0.0025	0.1004	0.1381
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.1004	0.1004
Brugia malayi	Cathepsin L-like precursor	0.0025	0.1053	0.2035
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0025	0.1004	0.1381
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.1004	0.1004
Echinococcus granulosus	fmrfamide receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.1004	0.1004
Brugia malayi	Cathepsin L-like precursor	0.0025	0.1053	0.2035
Leishmania major	cathepsin L-like protease	0.0025	0.1053	0.1972
Onchocerca volvulus		0.0025	0.1004	0.1381
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Schistosoma mansoni	biogenic amine receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.1004	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0025	0.1053	0.2127
Brugia malayi	neuropeptide F receptor	0.0025	0.1004	0.1939
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.1053	0.1972
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.1004	0.1004
Onchocerca volvulus	Cathepsin F homolog	0.0025	0.1053	0.1483
Schistosoma mansoni	loxhd1	0.0022	0.074	0.074
Leishmania major	cathepsin L-like protease	0.0025	0.1053	0.1972
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Loa Loa (eye worm)	doublecortin family protein	0.0022	0.074	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Onchocerca volvulus		0.0025	0.1004	0.1381
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.1004	0.1004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.1004	0.1004
Echinococcus granulosus	g protein coupled receptor	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0025	0.1053	0.1483
Brugia malayi	hypothetical protein	0.0022	0.074	0.1429
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Echinococcus multilocularis	cysteine protease	0.0025	0.1053	0.1053
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.1004	0.1004
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0017	0.0335	0.0647
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.1053	0.1053
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1053	0.1972
Schistosoma mansoni	biogenic amine receptor	0.0025	0.1004	0.1004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.1053	0.2035
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.1004	0.1875
Brugia malayi	G protein-coupled receptor F59B2.13	0.0025	0.1004	0.1939
Schistosoma mansoni	rab6-interacting	0.0022	0.074	0.074
Schistosoma mansoni	amine GPCR	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0025	0.1053	0.1483
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	cathepsin l1	0.0017	0.0335	0.0335
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0071	0.4953	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Entamoeba histolytica	protein phosphatase regulatory subunit, putative	0.0074	0.5177	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Onchocerca volvulus		0.0025	0.1004	0.1381
Schistosoma mansoni	neuropeptide receptor	0.0025	0.1004	0.1004
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0335	0.0647
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.1004	0.1004
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.1004	0.1004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Echinococcus multilocularis	cysteine protease	0.0025	0.1053	0.1053
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.1004	0.1004
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.1004	0.1004
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0025	0.1053	0.1053
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.074	0.074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Echinococcus multilocularis	sex peptide receptor	0.0025	0.1004	0.1004
Trypanosoma brucei	cytochrome P450, putative	0.0014	0.0041	0.0078
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0025	0.1053	0.1053
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.1004	0.1004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.1053	0.2035
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0025	0.1053	0.2127
Onchocerca volvulus		0.0025	0.1004	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Echinococcus granulosus	RUN	0.0022	0.074	0.074
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	ORL1-like opioid receptor	0.0025	0.1004	0.1939
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.1004	0.1004
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.1004	0.1004
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.1004	0.1875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0017	0.0335	0.0647
Brugia malayi	hypothetical protein	0.0025	0.1004	0.1939
Brugia malayi	Dopamine receptor	0.0025	0.1004	0.1939
Schistosoma mansoni	histamine h1 receptor	0.0025	0.1004	0.1004
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0071	0.4953	0.9568
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.1004	0.1004
Trypanosoma brucei	protein phosphatase 2A regulatory subunit, putative	0.0074	0.5177	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Echinococcus multilocularis	G protein coupled receptor 139	0.0025	0.1004	0.1004
Echinococcus multilocularis	RUN	0.0022	0.074	0.074
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.1004	0.1004
Onchocerca volvulus		0.0025	0.1053	0.1483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.1053	0.2035
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.1004	0.1004
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0071	0.4953	0.9568
Brugia malayi	neuropeptide F receptor	0.0025	0.1004	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1004	0.1875
Brugia malayi	sulfakinin receptor protein	0.0025	0.1004	0.1939
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.1053	0.2035
Schistosoma mansoni	neuropeptide receptor	0.0025	0.1004	0.1004
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.1004	0.1004
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.1053	0.2035
Onchocerca volvulus		0.0025	0.1004	0.1381
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.074	0.074
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.1004	0.1004
Leishmania major	cathepsin L-like protease	0.0025	0.1053	0.1972
Brugia malayi	RE15519p	0.0025	0.1004	0.1939
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0335	0.0335
Schistosoma mansoni	hypothetical protein	0.0025	0.1004	0.1004

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 1 mM	Exogenous inhibition of Serine/threonine protein phosphatase 1 (PP1)	ChEMBL.	11881984
IC50 (binding)	> 10 mM	Exogenous inhibition concentration of Serine/threonine protein phosphatase 2B (PP2B)	ChEMBL.	11881984
IC50 (binding)	= 4 uM	Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)	ChEMBL.	11881984
IC50 (binding)	= 4 uM	Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)	ChEMBL.	11881984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
ChEMBL: CHEMBL17664
PubChem: 125904

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 18692