Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | 0.0182 | 0.3875 | 0.4436 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.003 | 0.0235 | 0.0215 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0078 | 0.0089 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0024 | 0.0106 | 0.0122 |
Schistosoma mansoni | gliotactin | 0.0023 | 0.0078 | 0.0078 |
Leishmania major | basic transcription factor 3a, putative | 0.003 | 0.0235 | 0.0215 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0024 | 0.0106 | 0.0122 |
Onchocerca volvulus | 0.0382 | 0.8673 | 1 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0382 | 0.8673 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0028 | 0.0185 | 0.0157 |
Echinococcus granulosus | acetylcholinesterase | 0.0137 | 0.2814 | 0.3245 |
Brugia malayi | Endoplasmin precursor | 0.0028 | 0.0185 | 0.0213 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0382 | 0.8673 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0106 | 0.0122 |
Brugia malayi | chromobox protein homolog 3 | 0.0033 | 0.0319 | 0.0367 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0023 | 0.0078 | 0.0078 |
Onchocerca volvulus | Netrin receptor homolog | 0.0024 | 0.0106 | 0.0122 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0078 | 0.0089 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0382 | 0.8673 | 1 |
Echinococcus granulosus | Ankyrin | 0.0025 | 0.0111 | 0.0128 |
Brugia malayi | heat shock protein 90 | 0.0028 | 0.0185 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0078 | 0.0089 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Echinococcus granulosus | heat shock protein 90 | 0.0022 | 0.005 | 0.0057 |
Echinococcus granulosus | neuroligin | 0.0023 | 0.0078 | 0.0089 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.3875 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0024 | 0.0086 | 0.0094 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.2981 | 0.2981 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0.0078 | 0.0032 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0023 | 0.0078 | 0.0089 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Mycobacterium ulcerans | thymidylate synthase | 0.0382 | 0.8673 | 1 |
Schistosoma mansoni | transcription factor btf3 | 0.003 | 0.0235 | 0.0235 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0028 | 0.0185 | 0.0157 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.2981 | 0.2981 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0137 | 0.2814 | 0.3245 |
Schistosoma mansoni | endoplasmin | 0.0028 | 0.0185 | 0.0185 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0382 | 0.8673 | 1 |
Onchocerca volvulus | 0.0023 | 0.0078 | 0.0089 | |
Brugia malayi | Heterochromatin protein 1 | 0.0059 | 0.0944 | 0.1088 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0319 | 0.0703 |
Schistosoma mansoni | acetylcholinesterase | 0.0023 | 0.0078 | 0.0078 |
Onchocerca volvulus | 0.0023 | 0.0078 | 0.0089 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0235 | 0.0485 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0375 | 0.8508 | 0.981 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0382 | 0.8673 | 0.8673 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0235 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0059 | 0.0944 | 0.1088 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0024 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0078 | 0.0089 |
Echinococcus multilocularis | acetylcholinesterase | 0.0137 | 0.2814 | 0.3245 |
Plasmodium vivax | heat shock protein 86, putative | 0.0028 | 0.0185 | 0.0213 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0235 | 0.0485 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0028 | 0.0185 | 0.0157 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0028 | 0.0185 | 0.0213 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0025 | 0.0111 | 0.0111 |
Echinococcus multilocularis | heat shock protein | 0.0028 | 0.0185 | 0.0213 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Echinococcus granulosus | transcription factor btf3 | 0.003 | 0.0235 | 0.0271 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0022 | 0.005 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0182 | 0.3875 | 0.4436 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.0078 | 0.0089 |
Onchocerca volvulus | 0.0023 | 0.0078 | 0.0089 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0024 | 0.0106 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0078 | 0.0089 |
Loa Loa (eye worm) | carboxylesterase | 0.0137 | 0.2814 | 0.3245 |
Plasmodium vivax | endoplasmin, putative | 0.0028 | 0.0185 | 0.0213 |
Echinococcus granulosus | endoplasmin | 0.0022 | 0.005 | 0.0057 |
Echinococcus multilocularis | acetylcholinesterase | 0.0137 | 0.2814 | 0.3245 |
Echinococcus multilocularis | transcription factor btf3 | 0.003 | 0.0235 | 0.0271 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0.0078 | 0.0073 |
Echinococcus multilocularis | heat shock protein 90 | 0.0028 | 0.0185 | 0.0213 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0023 | 0.0078 | 0.0089 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0078 | 0.0078 |
Echinococcus multilocularis | heat shock protein 90 | 0.0022 | 0.005 | 0.0057 |
Echinococcus granulosus | death domain containing protein | 0.0024 | 0.0106 | 0.0122 |
Trichomonas vaginalis | chromobox protein, putative | 0.0059 | 0.0944 | 0.2338 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0111 | 0.0128 |
Brugia malayi | thymidylate synthase | 0.0382 | 0.8673 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0319 | 0.0367 |
Plasmodium falciparum | heat shock protein 90 | 0.0028 | 0.0185 | 0.0213 |
Onchocerca volvulus | 0.0026 | 0.0146 | 0.0169 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0023 | 0.0078 | 0.0089 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0382 | 0.8673 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0023 | 0.0078 | 0.0078 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0028 | 0.0185 | 0.0157 |
Echinococcus granulosus | chromobox protein 1 | 0.0059 | 0.0944 | 0.1088 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0024 | 0.0106 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0078 | 0.0089 |
Echinococcus multilocularis | chromobox protein 1 | 0.0059 | 0.0944 | 0.1088 |
Brugia malayi | Protein kinase domain containing protein | 0.0024 | 0.0106 | 0.0122 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0023 | 0.0078 | 0.0089 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0028 | 0.0185 | 0.0157 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Schistosoma mansoni | chromobox protein | 0.0059 | 0.0944 | 0.0944 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0078 | 0.0089 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0078 | 0.0089 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0382 | 0.8673 | 1 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.003 | 0.0235 | 0.0271 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2814 | 0.3245 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0036 | 0.0379 | 0.0437 |
Schistosoma mansoni | endoplasmin | 0.0028 | 0.0185 | 0.0185 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0382 | 0.8673 | 1 |
Brugia malayi | Uncoordinated protein 44 | 0.0024 | 0.0106 | 0.0122 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0059 | 0.0944 | 0.1088 |
Echinococcus granulosus | carboxylesterase 5A | 0.0137 | 0.2814 | 0.3245 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0078 | 0.0089 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0106 | 0.0106 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.003 | 0.0235 | 0.0271 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.2814 | 0.3245 |
Echinococcus multilocularis | Ankyrin | 0.0025 | 0.0111 | 0.0128 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0375 | 0.8508 | 0.981 |
Echinococcus granulosus | acetylcholinesterase | 0.0137 | 0.2814 | 0.3245 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0078 | 0.0078 |
Onchocerca volvulus | 0.0023 | 0.0078 | 0.0089 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0023 | 0.0078 | 0.0089 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0023 | 0.0078 | 0.0089 |
Loa Loa (eye worm) | endoplasmin | 0.0028 | 0.0185 | 0.0213 |
Treponema pallidum | heat shock protein 90 | 0.0022 | 0.005 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0033 | 0.0319 | 0.0367 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0028 | 0.0185 | 1 |
Brugia malayi | hypothetical protein | 0.0182 | 0.3875 | 0.4468 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0235 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0078 | 0.0089 |
Schistosoma mansoni | chromobox protein | 0.0059 | 0.0944 | 0.0944 |
Trichomonas vaginalis | chromobox protein, putative | 0.0036 | 0.0379 | 0.0861 |
Onchocerca volvulus | 0.0023 | 0.0078 | 0.0089 | |
Loa Loa (eye worm) | ICD-1 protein | 0.003 | 0.0235 | 0.0271 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.003 | 0.0235 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0024 | 0.0086 | 0.0094 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0078 | 0.0089 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.2814 | 0.2814 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.0078 | 0.0032 |
Echinococcus granulosus | thymidylate synthase | 0.0382 | 0.8673 | 1 |
Toxoplasma gondii | NAC domain-containing protein | 0.003 | 0.0235 | 0.0059 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.0078 | 0.0089 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0137 | 0.2814 | 0.3245 |
Echinococcus granulosus | geminin | 0.0144 | 0.2981 | 0.3438 |
Schistosoma mansoni | netrin receptor unc5 | 0.0024 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2814 | 0.3245 |
Brugia malayi | beta-NAC-like protein | 0.003 | 0.0235 | 0.0271 |
Echinococcus multilocularis | endoplasmin | 0.0022 | 0.005 | 0.0057 |
Echinococcus multilocularis | thymidylate synthase | 0.0382 | 0.8673 | 1 |
Echinococcus multilocularis | neuroligin | 0.0023 | 0.0078 | 0.0089 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | thymidylate synthase | 0.0382 | 0.8673 | 1 |
Schistosoma mansoni | heat shock protein | 0.0028 | 0.0185 | 0.0185 |
Echinococcus granulosus | heat shock protein 90 | 0.0028 | 0.0185 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0078 | 0.0089 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0382 | 0.8673 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0.0078 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0146 | 0.0169 |
Trichomonas vaginalis | chromobox protein, putative | 0.0036 | 0.0379 | 0.0861 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.0078 | 0.0032 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0319 | 0.0703 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0022 | 0.005 | 0.0057 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.003 | 0.0235 | 0.0059 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Echinococcus multilocularis | geminin | 0.0144 | 0.2981 | 0.3438 |
Schistosoma mansoni | heat shock protein | 0.0028 | 0.0185 | 0.0185 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.2814 | 0.3245 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0024 | 0.0106 | 0.0122 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0185 | 0.0157 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0.0078 | 0.0032 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.003 | 0.0235 | 0.0215 |
Echinococcus granulosus | heat shock protein | 0.0028 | 0.0185 | 0.0213 |
Trichomonas vaginalis | heat shock protein, putative | 0.0028 | 0.0185 | 0.0353 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0024 | 0.0106 | 0.0122 |
Echinococcus multilocularis | chromobox protein 1 | 0.0059 | 0.0944 | 0.1088 |
Trichomonas vaginalis | chromobox protein, putative | 0.0059 | 0.0944 | 0.2338 |
Brugia malayi | Death domain containing protein | 0.0024 | 0.0106 | 0.0122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.