Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.0369 | 0.4028 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0141 | 0.0524 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0369 | 0.4028 | 0.7122 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0475 | 0.5655 | 0.2725 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0141 | 0.0524 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0475 | 0.5655 | 0.2725 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0141 | 0.0524 | 0.5 |
Brugia malayi | hypothetical protein | 0.0166 | 0.0906 | 0.1601 |
Echinococcus granulosus | neuropeptide s receptor | 0.0404 | 0.4562 | 0.0895 |
Onchocerca volvulus | 0.0166 | 0.0906 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0141 | 0.0524 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0141 | 0.0524 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0758 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0369 | 0.4028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 0.5655 | 1 |
Brugia malayi | hypothetical protein | 0.0475 | 0.5655 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0404 | 0.4562 | 0.0895 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0404 | 0.4562 | 0.0895 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0141 | 0.0524 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0369 | 0.4028 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0369 | 0.4028 | 0.7122 |
Brugia malayi | dihydrofolate reductase family protein | 0.0369 | 0.4028 | 0.7122 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0758 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0369 | 0.4028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0906 | 0.1601 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0709 | 0.9239 | 0.8726 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0404 | 0.4562 | 0.0895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.