Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Caenorhabditis elegans | Protein SKN-1, isoform B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.593 | 0.5409 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0073 | 0.2485 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0242 | 0.9941 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1203 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1203 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.2452 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0151 | 0.593 | 0.5965 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0244 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0242 | 0.9941 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0073 | 0.2485 | 0.25 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0151 | 0.593 | 0.5965 |
Onchocerca volvulus | 0.0151 | 0.593 | 1 | |
Mycobacterium ulcerans | thymidylate synthase | 0.0151 | 0.593 | 0.5965 |
Echinococcus granulosus | thymidylate synthase | 0.0151 | 0.593 | 0.5409 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0072 | 0.2452 | 0.2467 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1203 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0242 | 0.9941 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0244 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0072 | 0.2452 | 0.1429 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0242 | 0.9941 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0242 | 0.9941 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0073 | 0.2485 | 0.25 |
Brugia malayi | Dihydrofolate reductase | 0.0242 | 0.9941 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1203 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0151 | 0.593 | 0.5409 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0244 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0242 | 0.9941 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0244 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0242 | 0.9941 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0242 | 0.9941 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0242 | 0.9941 | 1 |
Brugia malayi | thymidylate synthase | 0.0151 | 0.593 | 0.5409 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0244 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 1.96 uM | PubChem BioAssay. SAR analysis to confirm small molecule inhibitors of SKN-1 in a fluorescence ratio assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 64 uM | PubChem BioAssay. SAR analysis to confirm small molecule inhibitors of SKN-1 via a heat-shock counterscreen assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.