Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0079 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0228 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0228 | 1 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0079 | 0 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0079 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0228 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0079 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0079 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0228 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0228 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0228 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0228 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0228 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0079 | 0 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0228 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0079 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0228 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0228 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0079 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0228 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.