Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0641 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0378 | 0.5477 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0378 | 0.5477 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.063 | 0.9814 | 0.9706 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0378 | 0.5477 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0641 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.063 | 0.9814 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0641 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.5291 | 0.5291 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0378 | 0.5477 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0641 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.063 | 0.9814 | 0.9814 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.3187 | 0.3187 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.063 | 0.9814 | 0.9706 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.3187 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0641 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0378 | 0.5477 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0641 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.063 | 0.9814 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0641 | 1 | 1 |
Onchocerca volvulus | 0.0641 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 14 nM | Inhibition of Corticotropin releasing factor receptor 1-stimulated cAMP production | ChEMBL. | 12951129 |
IC50 (functional) | = 14 nM | Inhibition of Corticotropin releasing factor receptor 1-stimulated cAMP production | ChEMBL. | 12951129 |
Ki (binding) | = 5.7 nM | Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand | ChEMBL. | 12951129 |
Ki (binding) | = 5.7 nM | Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand | ChEMBL. | 12951129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.