TDR Targets

Basic information

Technical information

TDR Targets ID: 187022
Name: N-[[(1R,5S)-5-hydroxy-1,3,3-trimethylcyclohex yl]methyl]-2-methoxybenzenecarbothioamide
MW: 321.477 | Formula: C18H27NO2S
H donors: 1 H acceptors: 1 LogP: 4.11 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1/C(=N/C[C@@]1(C)C[C@@H](O)CC(C1)(C)C)/S
InChi: 1S/C18H27NO2S/c1-17(2)9-13(20)10-18(3,11-17)12-19-16(22)14-7-5-6-8-15(14)21-4/h5-8,13,20H,9-12H2,1-4H3,(H,19,22)/t13-,18-/m0/s1
InChiKey: FOYHHLWSNRMDEW-UGSOOPFHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[[(1R,5S)-5-hydroxy-1,3,3-trimethyl-cyclohexyl]methyl]-2-methoxy-benzenecarbothioamide
N-[[(1R,5S)-5-hydroxy-1,3,3-trimethyl-cyclohexyl]methyl]-2-methoxy-thiobenzamide
AIDS-154692
AIDS154692
Benzenecarbothioamide, N-[[(1R,5S)-5-hydroxy-1,3,3-trimethylcyclohexyl]methyl]-2-methoxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Schistosoma mansoni	hypothetical protein	0.0089	0.0138	0.0137
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0089	0.0138	0.014
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0089	0.0138	0.014
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Plasmodium falciparum	phosphoglucomutase-2	0.0025	0.0023	0.1134
Echinococcus granulosus	tyrosine protein kinase csk	0.0089	0.0138	0.014
Toxoplasma gondii	phosphoglycerate mutase	0.0025	0.0023	0.1586
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.1441	0.2561	0.9829
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0023	0.0022
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0025	0.0023	0.0057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Entamoeba histolytica	cysteine surface protein, putative	0.0089	0.0138	0.0838
Leishmania major	hypothetical protein, conserved	0.0025	0.0023	0.0057
Mycobacterium ulcerans	hydrolase MutT1	0.0025	0.0023	0.0097
Echinococcus multilocularis	tyrosine protein kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	tyrosine protein kinase csk	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0025	0.0023	0.0791
Mycobacterium tuberculosis	Conserved protein	0.0025	0.0023	0.0791
Trypanosoma cruzi	protein kinase, putative	0.0089	0.0138	0.0502
Brugia malayi	GCC2 and GCC3 family protein	0.0013	0.0001	0.0001
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Onchocerca volvulus		0.0089	0.0138	0.0527
Mycobacterium tuberculosis	Probable reductase	0.0109	0.0173	0.8837
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0089	0.0138	0.014
Brugia malayi	Tyrosine-protein kinase PR2	0.0089	0.0138	0.014
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0089	0.0138	0.014
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0025	0.0023	1
Brugia malayi	Augmenter of liver regeneration	0.0035	0.004	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Entamoeba histolytica	serine/threonine kinase, putative	0.0089	0.0138	0.0838
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0025	0.0023	0.0791
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0089	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Onchocerca volvulus		0.0089	0.0138	0.0527
Toxoplasma gondii	Erv1 / Alr family protein	0.0035	0.004	0.2865
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0089	0.0138	0.014
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0089	0.0138	0.014
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0018	0.0011	0.0012
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0025	0.0023	0.0057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Echinococcus granulosus	tyrosine protein kinase Srms	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0023	0.0057
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Entamoeba histolytica	ankyrin repeat protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0089	0.0138	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0023	0.0022
Brugia malayi	EGF-like domain containing protein	0.0013	0.0001	0.0001
Trypanosoma brucei	trypanothione reductase	0.0048	0.0064	0.0215
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0089	0.0138	0.014
Echinococcus multilocularis	epidermal growth factor receptor	0.0089	0.0138	0.014
Onchocerca volvulus		0.0089	0.0138	0.0527
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0025	0.0023	0.0791
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0089	0.0138	0.014
Echinococcus granulosus	raf serine:threonine protein kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	tyrosine kinase	0.0089	0.0138	0.014
Trypanosoma brucei	Pseudokinase, putative	0.0089	0.0138	0.0502
Brugia malayi	notch-like transmembrane receptor	0.0013	0.0001	0.0001
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0025	0.0023	0.0057
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Echinococcus multilocularis	heat shock protein 70	0.0089	0.0138	0.014
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0013	0.0001	0.0001
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.5501	0.984	1
Loa Loa (eye worm)	hypothetical protein	0.5501	0.984	1
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0025	0.0023	0.1586
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0023	0.0097
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Echinococcus granulosus	protein tyrosine kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0023	0.0057
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0061	0.0061
Mycobacterium ulcerans	acid phosphatase	0.0025	0.0023	0.0097
Giardia lamblia	Protein 21.1	0.0089	0.0138	0.0898
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0089	0.0138	0.0137
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Brugia malayi	SH2 domain containing protein	0.0089	0.0138	0.014
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0011	0.0011
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0018	0.0011	0.0733
Entamoeba histolytica	serine/threonine kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Mycobacterium ulcerans	lipoprotein LpqD	0.0025	0.0023	0.0097
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0089	0.0138	0.014
Giardia lamblia	GTOR	0.0018	0.0011	0.0066
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0025	0.0023	0.0791
Brugia malayi	Calcium binding EGF domain containing protein	0.0013	0.0001	0.0001
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0089	0.0138	0.014
Onchocerca volvulus		0.0089	0.0138	0.0527
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0089	0.0138	0.014
Onchocerca volvulus		0.0089	0.0138	0.0527
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0089	0.0138	0.0527
Schistosoma mansoni	hypothetical protein	0.0025	0.0023	0.0022
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0008	0.0007
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0089	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0089	0.0138	0.014
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0011	0.0012
Onchocerca volvulus		0.1465	0.2605	1
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Echinococcus granulosus	c src tyrosine kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	serine/threonine kinase, putative	0.0089	0.0138	0.0838
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0011	0.0011
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0089	0.0138	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus granulosus	tyrosine kinase	0.0089	0.0138	0.014
Brugia malayi	hypothetical protein	0.0089	0.0138	0.014
Brugia malayi	Muscle positioning protein 4	0.0013	0.0001	0.0001
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0023	0.0057
Toxoplasma gondii	protein kinase domain-containing protein	0.0089	0.0138	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0089	0.0138	0.014
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0089	0.0138	0.014
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Trypanosoma cruzi	protein kinase, putative	0.0089	0.0138	0.0502
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Mycobacterium tuberculosis	Probable oxidoreductase	0.0121	0.0195	1
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0025	0.0023	0.0057
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0023	0.0057
Onchocerca volvulus		0.0089	0.0138	0.0527
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Schistosoma mansoni	phosphoglycerate mutase	0.0025	0.0023	0.0022
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Plasmodium vivax	phosphoglycerate mutase, putative	0.0025	0.0023	0.1134
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0865	0.1529	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Entamoeba histolytica	hypothetical protein	0.0025	0.0023	0.008
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0025	0.0023	0.0057
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0023	0.0023
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0089	0.0138	0.014
Giardia lamblia	Kinase, NEK	0.0089	0.0138	0.0898
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0089	0.0138	0.014
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0089	0.0138	0.014
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0035	0.004	0.2482
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.0173	0.8837
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Leishmania major	trypanothione reductase	0.0048	0.0064	0.0215
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Brugia malayi	Cadherin domain containing protein	0.0013	0.0001	0.0001
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.0138	0.014
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1465	0.2605	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	integrin linked protein kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.5501	0.984	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	c src tyrosine kinase	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0089	0.0138	0.014
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0025	0.0023	0.0057
Brugia malayi	SRC-1	0.0089	0.0138	0.014
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0008	0.0007
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0023	0.0022
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0064	0.428
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0089	0.0138	0.014
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0023	0.0022
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Brugia malayi	EGF-like domain containing protein	0.0013	0.0001	0.0001
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0089	0.0138	0.0137
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0023	0.1134
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0025	0.0023	0.0097
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0035	0.004	0.0125
Brugia malayi	Furin-like cysteine rich region family protein	0.0089	0.0138	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.0138	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0018	0.0011	0.0012
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0023	0.0022
Loa Loa (eye worm)	TK/DDR protein kinase	0.0089	0.0138	0.014
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0011	0.0012
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0089	0.0138	1
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Brugia malayi	ephrin receptor 1 precursor	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.1441	0.2561	0.9829
Echinococcus multilocularis	transfer RNA-Thr	0.0089	0.0138	0.014
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0023	0.0022
Echinococcus granulosus	epidermal growth factor receptor	0.0089	0.0138	0.014
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.0138	0.0137
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0025	0.0023	0.1134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0089	0.0138	0.0527
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0089	0.0138	0.0137
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0023	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus granulosus	tyrosine kinase	0.0089	0.0138	0.014
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0025	0.0023	0.0057
Schistosoma mansoni	ephrin receptor	0.0089	0.0138	0.0137
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0008	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.0138	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0089	0.0138	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.0011	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.0138	1
Brugia malayi	Thioredoxin reductase	0.0048	0.0064	0.0065
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.5501	0.984	1
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0025	0.0023	0.1586
Onchocerca volvulus		0.0089	0.0138	0.0527
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	protein kinase	0.0089	0.0138	0.014
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0089	0.0138	0.014
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0089	0.0138	0.014
Onchocerca volvulus		0.0089	0.0138	0.0527
Brugia malayi	integrin-linked kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0625	0.1099	0.4202
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0089	0.0138	0.014
Brugia malayi	Raf kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0089	0.0138	0.014
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0089	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Plasmodium falciparum	protein kinase, putative	0.0089	0.0138	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	serine/threonine protein kinase	0.0089	0.0138	0.014
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0025	0.0023	0.0022
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0018	0.0011	0.0012
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0023	0.0022
Brugia malayi	EGF-like domain containing protein	0.0013	0.0001	0.0001
Plasmodium falciparum	protein kinase, putative	0.0089	0.0138	1
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.0625	0.1099	0.4202
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Brugia malayi	phosphoglycerate mutase family protein	0.0025	0.0023	0.0023
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0089	0.0138	0.014
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0089	0.0138	0.014
Echinococcus granulosus	tyrosine protein kinase csk	0.0089	0.0138	0.014
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0023	0.0059
Echinococcus granulosus	tyrosine protein kinase Blk	0.0089	0.0138	0.014
Onchocerca volvulus	Protein UBASH3A homolog	0.0025	0.0023	0.0084
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0023	0.0057
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.0138	0.014
Echinococcus multilocularis	tyrosine kinase	0.0089	0.0138	0.014
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0011	0.0012
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0089	0.0138	0.0137
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0816	0.1442	0.1464
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Echinococcus multilocularis	tyrosine protein kinase shark	0.0089	0.0138	0.014
Onchocerca volvulus		0.0089	0.0138	0.0527
Onchocerca volvulus		0.0025	0.0023	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Leishmania major	phosphoglycerate mutase protein, putative	0.0025	0.0023	0.0057
Trichomonas vaginalis	STE family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0008	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0011	0.001
Loa Loa (eye worm)	TK/ALK protein kinase	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Echinococcus granulosus	protein kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0023	0.1134
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0061	0.0062
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Trichomonas vaginalis	CAMK family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	tyrosin kinase, putative	0.0089	0.0138	0.0838
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0023	0.0023
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Loa Loa (eye worm)	TK/Met protein kinase	0.0089	0.0138	0.014
Schistosoma mansoni	hypothetical protein	0.0025	0.0023	0.0022
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0089	0.0138	0.014
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK/RYK protein kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0023	0.0022
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK/ROR protein kinase	0.0089	0.0138	0.014
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0064	0.0064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0008	0.0046
Loa Loa (eye worm)	hypothetical protein	0.084	0.1484	0.1508
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Echinococcus multilocularis	activin receptor type	0.0089	0.0138	0.014
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0018	0.0011	0.0012
Brugia malayi	Calcium binding EGF domain containing protein	0.0013	0.0001	0.0001
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0089	0.0138	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0089	0.0138	1
Echinococcus multilocularis	phosphoglycerate mutase	0.0025	0.0023	0.0022
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Echinococcus granulosus	tyrosine kinase	0.0089	0.0138	0.014
Toxoplasma gondii	Erv1 / Alr family protein	0.0035	0.004	0.2865
Entamoeba histolytica	receptor protein kinase, putative	0.0089	0.0138	0.0838
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0089	0.0138	0.014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0061	0.0061
Toxoplasma gondii	STE kinase	0.0089	0.0138	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0089	0.0138	0.0137
Schistosoma mansoni	hypothetical protein	0.0025	0.0023	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0089	0.0138	0.014
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0025	0.0023	0.0057
Entamoeba histolytica	receptor protein kinase, putative	0.0089	0.0138	0.0838
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0023	0.1171
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0023	0.1134
Echinococcus granulosus	tyrosine protein kinase csk	0.0089	0.0138	0.014
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.0138	1
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0023	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0121	0.0195	1
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0035	0.004	0.0125
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Onchocerca volvulus		0.0089	0.0138	0.0527
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Echinococcus granulosus	natriuretic peptide receptor 1	0.0089	0.0138	0.014
Leishmania major	hypothetical protein, unknown function	0.0025	0.0023	0.0057
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	hepatopoietin HPO2	0.0035	0.004	0.004
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.0138	0.0137
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Mycobacterium ulcerans	phosphoglycerate mutase	0.0025	0.0023	0.0097
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0018	0.0011	0.0012
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0023	0.1621
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0089	0.0138	0.014
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Loa Loa (eye worm)	SRC-1	0.0089	0.0138	0.014
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0018	0.0011	0.0012
Echinococcus granulosus	activated cdc42 kinase 1	0.0089	0.0138	0.014
Onchocerca volvulus		0.0089	0.0138	0.0527
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0089	0.0138	0.014
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0023	0.0022
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.0011	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0121	0.0195	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Onchocerca volvulus		0.0089	0.0138	0.0527
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.1441	0.2561	0.9829
Schistosoma mansoni	phosphoglycerate mutase	0.0025	0.0023	0.0022
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.0173	0.8837
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0035	0.004	0.0125
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0089	0.0138	0.0502
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0089	0.0138	0.014
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Giardia lamblia	Kinase	0.0089	0.0138	0.0898
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0089	0.0138	0.014
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0035	0.004	0.2482
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK/ACK protein kinase	0.0089	0.0138	0.014
Trypanosoma brucei	protein kinase, putative	0.0089	0.0138	0.0502
Onchocerca volvulus	Tyrosine kinase homolog	0.0089	0.0138	0.0527
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Schistosoma mansoni	serine/threonine RGC	0.0089	0.0138	0.0137
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.0173	0.8837
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Entamoeba histolytica	hypothetical protein, conserved	0.0089	0.0138	0.0838
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0018	0.0011	0.0012
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0018	0.0011	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0025	0.0023	0.0057
Onchocerca volvulus		0.0025	0.0023	0.0084
Brugia malayi	C-terminal src kinase protein 1	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0089	0.0138	0.014
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0089	0.0138	0.0502
Echinococcus multilocularis	insulin receptor	0.0089	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Schistosoma mansoni	hypothetical protein	0.0025	0.0023	0.0022
Brugia malayi	EGF-like domain containing protein	0.0013	0.0001	0.0001
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0089	0.0138	0.014
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0025	0.0023	0.0791
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0089	0.0138	0.014
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0023	0.0057
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.0011	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0016
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.0173	0.8737
Echinococcus granulosus	tyrosine protein kinase shark	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0025	0.0023	0.0022
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0089	0.0138	0.014
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0089	0.0138	0.014
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Echinococcus multilocularis	protein kinase	0.0089	0.0138	0.014
Brugia malayi	Cadherin domain containing protein	0.0013	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0011	0.001
Echinococcus multilocularis	epidermal growth factor receptor	0.0089	0.0138	0.014
Onchocerca volvulus	Protein UBASH3A homolog	0.0025	0.0023	0.0084
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0035	0.004	0.004
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0025	0.0023	0.1586
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0064	0.428
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0064	0.2985
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0023	0.1134
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0089	0.0138	0.014
Echinococcus granulosus	tyrosine protein kinase pr2	0.0089	0.0138	0.014
Entamoeba histolytica	tyrosin kinase, putative	0.0089	0.0138	0.0838
Leishmania major	phosphoglycerate mutase, putative	0.0025	0.0023	0.0057
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0089	0.0138	0.014
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0025	0.0023	0.0057
Loa Loa (eye worm)	TK/ABL protein kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0089	0.0138	0.014
Plasmodium falciparum	tyrosine kinase-like protein	0.0089	0.0138	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0089	0.0138	0.0137
Echinococcus granulosus	integrin linked protein kinase	0.0089	0.0138	0.014
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0089	0.0138	0.014
Brugia malayi	phosphoglycerate mutase family protein	0.0025	0.0023	0.0023
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0008	0.5
Brugia malayi	Calcium binding EGF domain containing protein	0.0013	0.0001	0.0001
Onchocerca volvulus		0.0089	0.0138	0.0527
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Brugia malayi	Protein kinase domain containing protein	0.5501	0.984	1
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0064	0.4572
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.0138	0.0137
Leishmania major	protein kinase, putative	0.0089	0.0138	0.0502
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0061	0.006
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0089	0.0138	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0089	0.0138	1
Echinococcus multilocularis	protein tyrosine kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	AGC family protein kinase	0.0089	0.0138	1
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0089	0.0138	0.014
Leishmania major	hypothetical protein, conserved	0.0025	0.0023	0.0057
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0023	0.1134
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0025	0.0023	0.0057
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0025	0.0023	0.0057
Entamoeba histolytica	serine/threonine kinase, putative	0.0089	0.0138	0.0838
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0035	0.004	0.0125
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Brugia malayi	EGF-like domain containing protein	0.0013	0.0001	0.0001
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Brugia malayi	protein-tyrosine kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	tyrosine protein kinase csk	0.0089	0.0138	0.014
Trichomonas vaginalis	protein kinase atn1, putative	0.0089	0.0138	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0023	0.0023
Entamoeba histolytica	tyrosin kinase, putative	0.0089	0.0138	0.0838
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0025	0.0023	0.0057
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0064	0.428
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0018	0.0011	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Onchocerca volvulus	Protein UBASH3A homolog	0.0025	0.0023	0.0084
Schistosoma mansoni	6-phosphofructokinase	0.1465	0.2605	0.2604
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0025	0.0023	0.0057
Plasmodium vivax	protein kinase, putative	0.0089	0.0138	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.0173	0.8837
Giardia lamblia	Kinase, NEK	0.0089	0.0138	0.0898
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0061	0.0061
Mycobacterium ulcerans	hypothetical protein	0.0865	0.1529	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0089	0.0138	0.014
Treponema pallidum	phosphoglyceromutase	0.0025	0.0023	1
Mycobacterium ulcerans	phosphoglyceromutase	0.0025	0.0023	0.0097
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Schistosoma mansoni	ephrin receptor	0.0089	0.0138	0.0137
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0025	0.0023	0.0097
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0025	0.0023	0.1586
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0018	0.0011	0.0012
Schistosoma mansoni	tyrosine protein kinase	0.0089	0.0138	0.0137
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0089	0.0138	0.014
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK protein kinase	0.0089	0.0138	0.014
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0089	0.0138	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0061	0.006
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0011	0.001
Leishmania major	glycerolphosphate mutase, putative	0.0025	0.0023	0.0057
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0023	0.0059
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0089	0.0138	0.014
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0011	0.0012
Loa Loa (eye worm)	TK/INSR protein kinase	0.0089	0.0138	0.014
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0089	0.0138	1
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1465	0.2605	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0138	0.0838
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0023	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus multilocularis	FL cytokine receptor	0.0089	0.0138	0.014
Plasmodium falciparum	protein kinase, putative	0.0089	0.0138	1
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0025	0.0023	0.1586
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0008	0.0008
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0025	0.0023	0.0791
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0025	0.0023	0.0077
Echinococcus multilocularis	activated cdc42 kinase 1	0.0089	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.1441	0.2561	0.2602
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Leishmania major	hypothetical protein, conserved	0.0089	0.0138	0.0502
Brugia malayi	UBASH3A protein homolog	0.0025	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0089	0.0138	0.014
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0025	0.0023	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Giardia lamblia	Hypothetical protein	0.0865	0.1529	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0089	0.0138	0.014
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0625	0.1099	0.4202
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0089	0.0138	0.014
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0023	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0089	0.0138	0.014
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0025	0.0023	0.0022
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0089	0.0138	0.014
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Plasmodium falciparum	glutathione reductase	0.0048	0.0064	0.428
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Schistosoma mansoni	protein tyrosine kinase	0.0089	0.0138	0.0137
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.1465	0.2605	0.2647
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0018	0.0011	0.0012
Brugia malayi	Tyrosine-protein kinase abl-1	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Schistosoma mansoni	tyrosine kinase	0.0089	0.0138	0.0137
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Echinococcus granulosus	tyrosine protein kinase HCK	0.0089	0.0138	0.014
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0025	0.0023	0.1134
Echinococcus granulosus	tyrosine protein kinase	0.0089	0.0138	0.014
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0025	0.0023	0.0057
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0089	0.0138	0.0502
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0023	0.0097
Brugia malayi	SH2 domain containing protein	0.0089	0.0138	0.014
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1465	0.2605	1
Brugia malayi	EGF-like domain containing protein	0.0013	0.0001	0.0001
Onchocerca volvulus		0.0089	0.0138	0.0527
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0089	0.0138	0.0838
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0089	0.0138	0.014
Trichomonas vaginalis	TK family protein kinase	0.0089	0.0138	1
Brugia malayi	glutathione reductase	0.0048	0.0064	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0138	0.014
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0025	0.0023	0.0791
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0089	0.0138	0.0838
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0035	0.004	0.004
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0089	0.0138	0.014
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0089	0.0138	0.014
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0064	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.0138	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0089	0.0138	0.014
Leishmania major	hypothetical protein, conserved	0.0025	0.0023	0.0057
Entamoeba histolytica	hypothetical protein	0.0089	0.0138	0.0838
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0121	0.0195	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.5501	0.984	1
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Brugia malayi	EGF-like domain containing protein	0.0013	0.0001	0.0001
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0025	0.0023	0.0077
Leishmania major	hypothetical protein, conserved	0.0035	0.004	0.0125
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0089	0.0138	0.014
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Schistosoma mansoni	protein kinase	0.0089	0.0138	0.0137
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.0865	0.1529	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1465	0.2605	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0008	0.0509
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.0138	0.014
Onchocerca volvulus	Protein UBASH3A homolog	0.0025	0.0023	0.0084
Leishmania major	protein kinase, putative	0.0089	0.0138	0.0502
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0089	0.0138	0.0502
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0011	0.0235
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0089	0.0138	0.0502
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.0173	0.8837
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.0138	1
Echinococcus granulosus	activin receptor type	0.0089	0.0138	0.014
Loa Loa (eye worm)	phosphoglycerate mutase	0.0025	0.0023	0.0022
Echinococcus granulosus	epidermal growth factor receptor	0.0089	0.0138	0.014
Echinococcus granulosus	ephrin type A receptor 4 A	0.0089	0.0138	0.014
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0089	0.0138	0.0137
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0017	0.0035
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0008	0.0509
Brugia malayi	Guanylyl cyclase protein 23	0.0089	0.0138	0.014
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0018	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.1465	0.2605	0.2647
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0025	0.0023	0.0077
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0025	0.0023	0.0057
Entamoeba histolytica	tyrosin kinase, putative	0.0089	0.0138	0.0838
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0011	0.001
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0025	0.0023	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Mycobacterium tuberculosis	Conserved protein	0.0025	0.0023	0.0791
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0064	0.0064
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0089	0.0138	1
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0064	0.0064
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1441	0.2561	0.9829
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0089	0.0138	0.014
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0025	0.0023	0.0022
Trypanosoma cruzi	target of rapamycin kinase 3	0.0018	0.0011	0.0012
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0089	0.0138	0.014
Onchocerca volvulus		0.0025	0.0023	0.0084
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Brugia malayi	hypothetical protein	0.0089	0.0138	0.014
Loa Loa (eye worm)	TK/EPH protein kinase	0.0089	0.0138	0.014
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Schistosoma mansoni	hypothetical protein	0.0025	0.0023	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0089	0.0138	0.014
Echinococcus granulosus	kinase suppressor of Ras 1	0.0089	0.0138	0.014
Schistosoma mansoni	hypothetical protein	0.0025	0.0023	0.0022
Giardia lamblia	Hypothetical protein	0.0865	0.1529	1
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Entamoeba histolytica	ankyrin repeat protein	0.0089	0.0138	0.0838
Echinococcus multilocularis	tyrosine protein kinase csk	0.0089	0.0138	0.014
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0089	0.0138	0.014
Toxoplasma gondii	protein kinase	0.0089	0.0138	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0089	0.0138	0.014
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0625	0.1099	0.4202
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.0138	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0023	0.0022
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0089	0.0138	0.014
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0011	0.001
Echinococcus granulosus	insulin receptor	0.0089	0.0138	0.014
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0138	0.014
Plasmodium vivax	phosphoglucomutase-2, putative	0.0025	0.0023	0.1134
Echinococcus granulosus	phosphoglycerate mutase	0.0025	0.0023	0.0022
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0089	0.0138	0.0838
Brugia malayi	Delta serrate ligand family protein	0.0013	0.0001	0.0001
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0023	0.1134
Trichomonas vaginalis	TKL family protein kinase	0.0089	0.0138	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0089	0.0138	0.014
Entamoeba histolytica	protein kinase, putative	0.0089	0.0138	0.0838
Entamoeba histolytica	tyrosine kinase, putative	0.0089	0.0138	0.0838
Onchocerca volvulus		0.0089	0.0138	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0023	0.0022
Plasmodium falciparum	tyrosine kinase-like protein	0.0089	0.0138	1
Mycobacterium ulcerans	phosphoglycerate mutase	0.0025	0.0023	0.0097
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0064	0.0215
Echinococcus granulosus	6 phosphofructo 2 kinase:fructose 2	0.1465	0.2605	0.2647
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0061	0.006

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (functional)	= 45 ug ml-1	The concentration causing a 50% reduction in cell viability in the absence of influenza infection on MDCK cells in cell protection assay.	ChEMBL.	12419365
EC50 (functional)	NA 0 ug ml-1	Anti-influenza activity on A/WSN/33 (H1N1 subtype) strain of influenza virus infected on MDCK cells in cell protection assay.	ChEMBL.	12419365
IC50 (functional)	NA 0 ug ml-1	Anti-influenza activity on A/WSN/33 (H1N1 subtype) strain of influenza virus infected on MDCK cells in cell protection assay.	ChEMBL.	12419365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL113207
PubChem: 3005492

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 187022