Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0239 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0239 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0126 | 0.1071 | 0.1071 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0239 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0239 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0239 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0239 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0239 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0239 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0239 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0239 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0239 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0239 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0239 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0126 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0126 | 0.1071 | 0.1071 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0239 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0239 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0239 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0239 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0239 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0126 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1071 | 0.1071 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0239 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0239 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0239 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0239 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0239 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0239 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0239 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0126 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0239 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0239 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0126 | 0.1071 | 0.1071 |
Schistosoma mansoni | thyroid hormone receptor | 0.0239 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0239 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0239 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0126 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1071 | 0.1071 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0239 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0239 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0239 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0239 | 1 | 1 |
Onchocerca volvulus | 0.0239 | 1 | 1 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0239 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0239 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0239 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0239 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0239 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0126 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0126 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0239 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0239 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0239 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0126 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.