Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2136 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2136 | 1 | 1 |
Onchocerca volvulus | 0.2136 | 1 | 0.5 | |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1261 | 0.5631 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2136 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2136 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.1261 | 0.5631 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.21 | 0.982 | 0.9604 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.21 | 0.982 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2136 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.1261 | 0.5631 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.21 | 0.982 | 0.9706 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2136 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.21 | 0.982 | 0.9706 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1261 | 0.5631 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.21 | 0.982 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.1261 | 0.5631 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 89.4 uM | Effective dose required for relaxation of the 30 mM KCl-induced contraction of rat aortic rings | ChEMBL. | 12852765 |
IC50 (functional) | = 3.1 uM | Concentration required to inhibit insulin release in rat | ChEMBL. | 12852765 |
ND (functional) | 0 | Inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 0.1 microM concentration; Not determined | ChEMBL. | 12852765 |
RIS (functional) | = 4.6 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 50 microM concentration | ChEMBL. | 12852765 |
RIS (functional) | = 21.1 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 10 microM concentration | ChEMBL. | 12852765 |
RIS (functional) | = 85.1 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 1 microM concentration | ChEMBL. | 12852765 |
Selectivity (functional) | = 29 | Estimated selectivity ratio of ED50 and IC50 in rat was calculated | ChEMBL. | 12852765 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.