Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.2898 | 0.5724 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4828 | 0.9824 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.2898 | 0.5724 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4911 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4828 | 0.9824 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.4911 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2815 | 0.5548 | 0.5509 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2898 | 0.5724 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4911 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4828 | 0.9824 | 0.9706 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.0087 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4911 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4828 | 0.9824 | 0.9822 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2898 | 0.5724 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4911 | 1 | 0.5 |
Onchocerca volvulus | 0.4911 | 1 | 0.5 | |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4828 | 0.9824 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4911 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4911 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.2898 | 0.5724 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.7 nM | Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells | ChEMBL. | 12951127 |
Ki (binding) | = 1.7 nM | Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells | ChEMBL. | 12951127 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.