Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0047 | 0.0151 | 0.0151 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0094 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0094 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0094 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0094 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0094 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0094 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0094 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0094 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0058 | 0.2407 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0094 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0094 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0094 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0094 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0046 | 0 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0094 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0083 | 0.7743 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0094 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0094 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0094 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0094 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0083 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0094 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0058 | 0.2407 | 0.2407 |
Trypanosoma cruzi | p450 reductase, putative | 0.0094 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0094 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 600 nM | In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex | ChEMBL. | 8568823 |
IC50 (binding) | = 600 nM | In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex | ChEMBL. | 8568823 |
ID50 (functional) | = 1.2 mg kg-1 | In vivo inhibitory activity against angiotensin II induced pressor response in anesthetized normotensive rats | ChEMBL. | 8568823 |
ID50 (functional) | = 1.2 mg kg-1 | In vivo inhibitory activity against angiotensin II induced pressor response in anesthetized normotensive rats | ChEMBL. | 8568823 |
Inhibition (functional) | = 25 % | Inhibitory activity of the compound against AII-Induced Pressor response at 3 mg/Kg at 6 hour | ChEMBL. | 8568823 |
Inhibition (functional) | = 26 % | Inhibitory activity of the compound against AII-Induced Pressor response at 3 mg/Kg at 1 hr | ChEMBL. | 8568823 |
Inhibition (functional) | = 28 % | Inhibitory activity of the compound against AII-Induced Pressor response at 3 mg/Kg at 3 hour | ChEMBL. | 8568823 |
Inhibition (functional) | = 40 % | Inhibitory activity of the compound against AII-Induced Pressor response at 10 mg/Kg at 1 hr | ChEMBL. | 8568823 |
Inhibition (functional) | = 70 % | Inhibitory activity of the compound against AII-Induced Pressor response at 10 mg/Kg at 3 hour | ChEMBL. | 8568823 |
Inhibition (functional) | = 75 % | Inhibitory activity of the compound against AII-Induced Pressor response at 10 mg/Kg at 6 hour | ChEMBL. | 8568823 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.