Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0168 | 0.0698 | 0.9721 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0092 | 0.0242 | 0.34 |
Brugia malayi | WGR domain containing protein | 0.0168 | 0.0698 | 0.9757 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0168 | 0.0698 | 0.5 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0168 | 0.0698 | 0.9816 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0092 | 0.0242 | 0.1272 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0456 | 0.5933 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1715 | 1 | 1 |
Brugia malayi | WGR domain containing protein | 0.0092 | 0.0242 | 0.1272 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.017 | 0.0711 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.017 | 0.0711 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.017 | 0.0711 | 1 |
Brugia malayi | thymidylate synthase | 0.017 | 0.0711 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.017 | 0.0711 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.017 | 0.0711 | 0.0547 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1715 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0092 | 0.0242 | 0.1272 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0092 | 0.0242 | 0.1379 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0168 | 0.0698 | 0.976 |
Onchocerca volvulus | 0.017 | 0.0711 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0242 | 0.251 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 0.5 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0175 | 0.0737 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.0173 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.