Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0051 | 0.3571 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0221 | 0.0619 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0221 | 0.0619 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0051 | 0.3571 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0051 | 0.3571 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0051 | 0.3571 | 0.3571 |
Brugia malayi | Smad1 | 0.0009 | 0.0221 | 0.0221 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.3571 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0221 | 0.0619 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0051 | 0.3571 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0221 | 0.0619 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0221 | 0.0619 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.3571 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0221 | 0.0619 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0221 | 0.0221 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0221 | 0.0619 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0051 | 0.3571 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0221 | 0.0221 |
Echinococcus multilocularis | smad | 0.0009 | 0.0221 | 0.0619 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0221 | 0.0221 |
Brugia malayi | isocitrate dehydrogenase | 0.0051 | 0.3571 | 0.3571 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.3571 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.3571 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0006 | 0 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0051 | 0.3571 | 0.5 |
Schistosoma mansoni | smad | 0.0009 | 0.0221 | 0.0619 |
Echinococcus granulosus | smad | 0.0009 | 0.0221 | 0.0619 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0006 | 0 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0051 | 0.3571 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0051 | 0.3571 | 0.3571 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0221 | 0.0221 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0006 | 0 | 0.5 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0221 | 0.0619 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0221 | 0.0221 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0051 | 0.3571 | 0.5 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0221 | 0.0619 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0051 | 0.3571 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0006 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0051 | 0.3571 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0221 | 0.0221 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0051 | 0.3571 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0221 | 0.0221 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0221 | 0.0619 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0051 | 0.3571 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0051 | 0.3571 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0221 | 0.0619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.