Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Antiinflammatory activity of the compound was determined by using Rat hyperalgesia assay;not determined | ChEMBL. | 12392741 |
ED50 (functional) | 0 mg kg-1 | Antiinflammatory activity of the compound was determined by using Rat adjuvant arthritis assay;not determined | ChEMBL. | 12392741 |
ED50 (functional) | = 4.5 mg kg-1 | Antiinflammatory activity of the compound was determined by using Rat paw edema assay | ChEMBL. | 12392741 |
ED50 (functional) | = 4.9 mg kg-1 | Antiinflammatory activity of the compound was determined by using Rat pyresis assay | ChEMBL. | 12392741 |
IC50 (binding) | = 0.5 uM | In vitro inhibitory potency of the compound was determined against Prostaglandin G/H synthase 2 in human whole blood assay | ChEMBL. | 12392741 |
IC50 (binding) | = 0.5 uM | In vitro inhibitory potency of the compound was determined against Prostaglandin G/H synthase 2 in human whole blood assay | ChEMBL. | 12392741 |
IC50 (binding) | > 100 uM | In vitro inhibitory potency of the compound was determined against Prostaglandin G/H synthase 1 in human whole blood assay | ChEMBL. | 12392741 |
IC50 (binding) | > 100 uM | In vitro inhibitory potency of the compound was determined against Prostaglandin G/H synthase 1 in human whole blood assay | ChEMBL. | 12392741 |
T1/2 (ADMET) | < 2 hr | Half-life of the compound was determined in rat | ChEMBL. | 12392741 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.