Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0476 | 1 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0476 | 1 | 0.5 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0476 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0476 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.041 | 0.5572 | 0.5572 |
Schistosoma mansoni | adenosylhomocysteinase | 0.041 | 0.5572 | 0.5572 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0476 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0476 | 1 | 0.5 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0476 | 1 | 0.5 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0476 | 1 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0476 | 1 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0476 | 1 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0476 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0476 | 1 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0476 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0476 | 1 | 0.5 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0476 | 1 | 0.5 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0476 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0476 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0476 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.041 | 0.5572 | 0.5572 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = 0 % | In vivo glucocorticoid profile, depression of thymus weight in rat at 5 mg/kg peroral dose | ChEMBL. | 8230118 |
Change (functional) | = 0 % | In vivo glucocorticoid profile, depression of adrenal weight in rat at 5 mg/kg peroral dose | ChEMBL. | 8230118 |
Change (functional) | = 0 % | In vivo glucocorticoid profile, depression of thymus weight in rat at 5 mg/kg peroral dose | ChEMBL. | 8230118 |
Change (functional) | = 0 % | In vivo glucocorticoid profile, depression of adrenal weight in rat at 5 mg/kg peroral dose | ChEMBL. | 8230118 |
ED50 (functional) | 0 mg kg-1 | In vivo antiinflammatory activity in the rat, alpha-tocopherol filled pouch 29 mg/kg peroral dose; IA = inactive | ChEMBL. | 8230118 |
RBA (binding) | = 1.8 % | Relative binding affinity against glucocorticoid receptor. | ChEMBL. | 8230118 |
RBA (binding) | = 1.8 % | Relative binding affinity against glucocorticoid receptor. | ChEMBL. | 8230118 |
Weight gain (functional) | = 0 | In vivo glucocorticoid profile, depression of body weight gain without altered food consumption in rat at 5 mg/kg peroral dose | ChEMBL. | 8230118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.