Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0099 | 0.0097 | 0.0097 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0099 | 0.0097 | 0.0165 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0099 | 0.0097 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0099 | 0.0097 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0099 | 0.0097 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.0086 | 0.0086 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.0054 | 0.0054 |
Trypanosoma brucei | glycerolphosphate mutase, putative | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium leprae | conserved hypothetical protein | 0.0099 | 0.0097 | 0.5 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma brucei | phosphoglycerate mutase protein, putative | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.0054 | 0.0054 |
Toxoplasma gondii | phosphoglycerate mutase PGMII | 0.0099 | 0.0097 | 1 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0099 | 0.0097 | 0.5 |
Leishmania major | glycerolphosphate mutase, putative | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium leprae | conserved hypothetical protein | 0.0099 | 0.0097 | 0.5 |
Schistosoma mansoni | apoptosis regulator bax | 0.0093 | 0.0086 | 0.0086 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0099 | 0.0097 | 0.0097 |
Onchocerca volvulus | 0.5866 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.5767 | 0.983 | 0.983 |
Entamoeba histolytica | phosphoglycerate mutase family protein. putative | 0.0099 | 0.0097 | 0.0165 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0099 | 0.0097 | 0.5 |
Plasmodium vivax | phosphoglucomutase-2, putative | 0.0099 | 0.0097 | 1 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 1 |
Leishmania major | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 0.0097 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0099 | 0.0097 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Toxoplasma gondii | phosphoglycerate mutase | 0.0099 | 0.0097 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0023 | 0.2331 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0099 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0023 | 0.0023 |
Schistosoma mansoni | 6-phosphofructokinase | 0.5866 | 1 | 1 |
Trypanosoma brucei | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 0.0097 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0099 | 0.0097 | 0.5 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0023 | 0.0023 |
Schistosoma mansoni | hypothetical protein | 0.0323 | 0.0481 | 0.0481 |
Echinococcus granulosus | X box binding protein 1 | 0.0323 | 0.0481 | 0.0481 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5767 | 0.983 | 0.983 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.0097 | 1 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0023 | 0.2331 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0093 | 0.0086 | 0.0086 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.5767 | 0.983 | 0.983 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0099 | 0.0097 | 0.0097 |
Leishmania major | hypothetical protein, conserved | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0099 | 0.0097 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2503 | 0.4225 | 0.4225 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5866 | 1 | 1 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0099 | 0.0097 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5866 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2503 | 0.4225 | 0.4225 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0099 | 0.0097 | 0.0097 |
Leishmania major | phosphoglycerate mutase protein, putative | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium ulcerans | hypothetical protein | 0.3462 | 0.5872 | 1 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0093 | 0.0086 | 0.0086 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0099 | 0.0097 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.3462 | 0.5872 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0074 | 0.0054 | 0.0091 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.0054 | 0.0054 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2503 | 0.4225 | 0.4225 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.0086 | 0.0086 |
Plasmodium vivax | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 1 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0099 | 0.0097 | 0.0097 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0099 | 0.0097 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.3363 | 0.5702 | 0.5702 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.5866 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0099 | 0.0097 | 0.5 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0099 | 0.0097 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0086 | 0.0086 |
Brugia malayi | UBASH3A protein homolog | 0.0099 | 0.0097 | 1 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0093 | 0.0086 | 0.0086 |
Treponema pallidum | phosphoglyceromutase | 0.0099 | 0.0097 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative | 0.0099 | 0.0097 | 0.0097 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0099 | 0.0097 | 1 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium tuberculosis | Conserved protein | 0.0099 | 0.0097 | 0.5 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0099 | 0.0097 | 0.0097 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 1 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0099 | 0.0097 | 0.0165 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0093 | 0.0086 | 0.8897 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0093 | 0.0086 | 0.0086 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0093 | 0.0086 | 0.0086 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.0054 | 0.0054 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0099 | 0.0097 | 0.5 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0099 | 0.0097 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.0054 | 0.0054 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 0.0097 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0099 | 0.0097 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0099 | 0.0097 | 0.0097 |
Leishmania major | phosphoglycerate mutase family member 5, putative | 0.0099 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0099 | 0.0097 | 0.5 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0099 | 0.0097 | 0.0097 |
Leishmania major | hypothetical protein, conserved | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0099 | 0.0097 | 0.0097 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0099 | 0.0097 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.5767 | 0.983 | 0.983 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.3462 | 0.5872 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5866 | 1 | 1 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.5866 | 1 | 1 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0093 | 0.0086 | 0.0086 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0099 | 0.0097 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.0097 | 1 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0099 | 0.0097 | 0.0097 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.0099 | 0.0097 | 1 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0099 | 0.0097 | 0.0097 |
Giardia lamblia | Hypothetical protein | 0.3462 | 0.5872 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0099 | 0.0097 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.0086 | 0.0086 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0099 | 0.0097 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5866 | 1 | 1 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0099 | 0.0097 | 0.0097 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.3462 | 0.5872 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0074 | 0.0054 | 0.5551 |
Loa Loa (eye worm) | hypothetical protein | 0.5767 | 0.983 | 0.983 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0099 | 0.0097 | 1 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0099 | 0.0097 | 1 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0099 | 0.0097 | 0.0097 |
Echinococcus multilocularis | X box binding protein 1 | 0.0323 | 0.0481 | 0.0481 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.2503 | 0.4225 | 0.4225 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.0097 | 0.0097 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0074 | 0.0054 | 0.0054 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0099 | 0.0097 | 1 |
Leishmania major | fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein | 0.0099 | 0.0097 | 0.0097 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0099 | 0.0097 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Aggregation (functional) | = 0 % | Effect on platelet aggregation induced by collagen in washed rabbit platelet | ChEMBL. | 10612588 |
Aggregation (functional) | = 60 % | Effect on platelet aggregation induced by arachidonic acid(AA) in washed rabbit platelet | ChEMBL. | 10612588 |
Aggregation (functional) | = 91.6 % | Effect on platelet aggregation induced by platelet activating factor(PAF) in washed rabbit platelet | ChEMBL. | 10612588 |
Aggregation (functional) | = 91.8 % | Effect on platelet aggregation induced by adenosine 5'-diphosphate (ADP) in washed rabbit platelet | ChEMBL. | 10612588 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.