Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0462 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0462 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0462 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0462 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0462 | 0.5 | 0.5 | |
Loa Loa (eye worm) | SRC-1 | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0462 | 0.5 | 0.5 | |
Brugia malayi | protein-tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0462 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0462 | 0.5 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0462 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0462 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0462 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0462 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0462 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0462 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0462 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0462 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce CMV(AD-169) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce CMV(Davis) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce VZV TK+(YS) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce VZV TK+(OKA) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Minimum inhibitory concentration required to reduce VZV TK-(07-1) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce VZV TK-(YS/R) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce CMV(AD-169) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce CMV(Davis) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce VZV TK+(YS) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce VZV TK+(OKA) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Minimum inhibitory concentration required to reduce VZV TK-(07-1) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 50 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce VZV TK-(YS/R) induced cytopathicity in HEL cells | ChEMBL. | 8765509 |
MIC (functional) | > 100 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce HIV-1(IIIb) induced cytopathicity in Human MT-4 cells | ChEMBL. | 8765509 |
MIC (functional) | > 100 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce HIV-2(ROD) induced cytopathicity in Human MT-4 cells | ChEMBL. | 8765509 |
MIC (functional) | > 100 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce HIV-1(IIIb) induced cytopathicity in Human MT-4 cells | ChEMBL. | 8765509 |
MIC (functional) | > 100 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce HIV-2(ROD) induced cytopathicity in Human MT-4 cells | ChEMBL. | 8765509 |
MIC (functional) | = 153 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce MSV induced cytopathicity in murine C3H/3T3 embryo fibroblasts | ChEMBL. | 8765509 |
MIC (functional) | = 153 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce MSV induced cytopathicity in murine C3H/3T3 embryo fibroblasts | ChEMBL. | 8765509 |
MIC (functional) | = 300 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce HSV-2(G) induced cytopathicity in E6SM cells | ChEMBL. | 8765509 |
MIC (functional) | = 300 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce VV induced cytopathicity in E6SM cells | ChEMBL. | 8765509 |
MIC (functional) | = 300 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce HSV-2(G) induced cytopathicity in E6SM cells | ChEMBL. | 8765509 |
MIC (functional) | = 300 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce VV induced cytopathicity in E6SM cells | ChEMBL. | 8765509 |
MIC (functional) | > 400 mg ml-1 | Compound was tested in vitro for minimum inhibitory concentration required to reduce HSV-1(KOS) induced cytopathicity in E6SM cells | ChEMBL. | 8765509 |
MIC (functional) | > 400 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce HSV-1 TK-(B2006) induced cytopathicity in E6SM cells | ChEMBL. | 8765509 |
MIC (functional) | > 400 mg ml-1 | Compound was tested in vitro for minimum inhibitory concentration required to reduce HSV-1(KOS) induced cytopathicity in E6SM cells | ChEMBL. | 8765509 |
MIC (functional) | > 400 mg ml-1 | Compound was tested in vitro for Minimum inhibitory concentration required to reduce HSV-1 TK-(B2006) induced cytopathicity in E6SM cells | ChEMBL. | 8765509 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.