Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0168 | 0.0698 | 0.9816 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0092 | 0.0242 | 0.1272 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0168 | 0.0698 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0092 | 0.0242 | 0.34 |
Brugia malayi | WGR domain containing protein | 0.0168 | 0.0698 | 0.9757 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0168 | 0.0698 | 0.9721 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1715 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.017 | 0.0711 | 0.0547 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.017 | 0.0711 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.017 | 0.0711 | 1 |
Brugia malayi | thymidylate synthase | 0.017 | 0.0711 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.017 | 0.0711 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.017 | 0.0711 | 1 |
Brugia malayi | WGR domain containing protein | 0.0092 | 0.0242 | 0.1272 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1715 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0456 | 0.5933 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0168 | 0.0698 | 0.976 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0092 | 0.0242 | 0.1272 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0092 | 0.0242 | 0.1379 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 1 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0175 | 0.0737 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.0173 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0242 | 0.251 |
Onchocerca volvulus | 0.017 | 0.0711 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.