Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.1688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1688 | 0.4015 |
Echinococcus multilocularis | acetylcholinesterase | 0.0102 | 0.1688 | 0.1688 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0102 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0102 | 0.1688 | 0.4015 |
Echinococcus granulosus | acetylcholinesterase | 0.0102 | 0.1688 | 0.1688 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0038 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0197 | 0.4204 | 0.4204 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0132 | 0.2494 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0416 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0102 | 0.1688 | 0.1688 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0197 | 0.4204 | 0.4204 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0197 | 0.4204 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.1688 | 0.4015 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.1688 | 0.1688 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0132 | 0.2494 | 0.5 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0086 | 0.1265 | 0.7497 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0038 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0416 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0102 | 0.1688 | 0.1688 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Trypanosoma cruzi | aminopeptidase, putative | 0.0038 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0102 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1688 | 0.4015 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0038 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0038 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.1688 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0197 | 0.4204 | 0.4204 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.