Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0033 | 0.4341 | 0.3011 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.1904 | 0.16 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1904 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4341 | 0.3011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Echinococcus granulosus | lamin | 0.0033 | 0.4341 | 0.3011 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.1904 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Onchocerca volvulus | 0.0033 | 0.4341 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.4184 | 0.3966 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4341 | 0.3011 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4341 | 0.4129 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4341 | 0.4129 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1904 | 0.16 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4341 | 0.3011 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1904 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.4341 | 0.5 | |
Echinococcus multilocularis | lamin | 0.0033 | 0.4341 | 0.3011 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1904 | 0.1904 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1904 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4341 | 0.4129 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1904 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.577 | 0.4775 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Schistosoma mansoni | lamin | 0.0033 | 0.4341 | 0.3011 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4341 | 0.4129 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4341 | 0.3011 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4341 | 0.4129 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1904 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1904 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.577 | 0.4775 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.577 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1904 | 0.5 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4341 | 0.3011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 4.6109 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 21.1923 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.