Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Bloom syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0029 | 0.1144 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0055 | 0.279 | 0.279 |
Echinococcus granulosus | bloom syndrome protein | 0.0055 | 0.279 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0037 | 0.1618 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0055 | 0.279 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0715 | 0.4422 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0055 | 0.279 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0029 | 0.1144 | 0.5 |
Schistosoma mansoni | DNA helicase recq5 | 0.0023 | 0.0715 | 0.3494 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0048 | 0.2361 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0023 | 0.0715 | 0.3494 |
Entamoeba histolytica | recQ family helicase, putative | 0.0029 | 0.1144 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0055 | 0.279 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0023 | 0.0715 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0715 | 0.4422 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0037 | 0.1646 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0055 | 0.279 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.0000000006015 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0043 | 0.2047 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0029 | 0.1144 | 0.5 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0023 | 0.0715 | 0.0715 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0715 | 0.0715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 13.5799 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.1821 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 30.1313 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 75.193 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.