Detailed information for compound 187243

Basic information

Technical information
  • TDR Targets ID: 187243
  • Name: 3,4-dichloro-N-(5-cyclopropyl-1H-pyrazol-3-yl )benzamide
  • MW: 296.152 | Formula: C13H11Cl2N3O
  • H donors: 2 H acceptors: 2 LogP: 3.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)Cl)Cl)Nc1n[nH]c(c1)C1CC1
  • InChi: 1S/C13H11Cl2N3O/c14-9-4-3-8(5-10(9)15)13(19)16-12-6-11(17-18-12)7-1-2-7/h3-7H,1-2H2,(H2,16,17,18,19)
  • InChiKey: CSEWCIIPSWNSJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-Benzamidoaminopyrazole deriv. 18

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens cyclin A2 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0066 0.0038 0.368
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0066 0.0038 0.368
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.3846 0.9829 0.9829
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.0066 0.0038 0.5
Schistosoma mansoni cyclin B 0.009 0.01 0.0098
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1669 0.419 0.419
Trichomonas vaginalis cyclin B, putative 0.009 0.01 1
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.0066 0.0038 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.3912 1 1
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0066 0.0038 0.0036
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0066 0.0038 0.0036
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.01 0.0098
Trichomonas vaginalis cyclins, putative 0.009 0.01 1
Loa Loa (eye worm) hypothetical protein 0.009 0.01 0.01
Echinococcus granulosus phosphoglycerate mutase 0.0066 0.0038 0.0036
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.3912 1 1
Schistosoma mansoni 6-phosphofructokinase 0.3912 1 1
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0066 0.0038 0.0036
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0066 0.0038 0.0062
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0066 0.0038 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.3912 1 1
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0066 0.0038 0.5
Mycobacterium ulcerans hypothetical protein 0.2309 0.5847 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.0066 0.0038 1
Mycobacterium leprae conserved hypothetical protein 0.0066 0.0038 0.5
Echinococcus multilocularis phosphoglycerate mutase 0.0066 0.0038 0.0036
Plasmodium falciparum phosphoglucomutase-2 0.0066 0.0038 1
Plasmodium falciparum phosphoglycerate mutase, putative 0.0066 0.0038 1
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0066 0.0038 0.0036
Leishmania major hypothetical protein, conserved 0.0066 0.0038 0.0036
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.0066 0.0038 0.5
Mycobacterium tuberculosis Conserved protein 0.0066 0.0038 0.5
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0066 0.0038 0.0036
Leishmania major hypothetical protein, unknown function 0.0066 0.0038 0.0036
Onchocerca volvulus 0.3912 1 1
Echinococcus multilocularis phosphoglycerate mutase 0.0066 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0066 0.0038 0.0036
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.01 0.0098
Echinococcus multilocularis cyclin B 0.009 0.01 0.0098
Loa Loa (eye worm) phosphoglycerate mutase 0.0066 0.0038 0.0038
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.01 1
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0066 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0038
Trypanosoma cruzi cyclin, putative 0.009 0.01 0.0098
Onchocerca volvulus 0.009 0.01 0.0062
Echinococcus multilocularis phosphoglycerate mutase 0.0066 0.0038 0.0036
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.3912 1 1
Trichomonas vaginalis cyclin B, putative 0.009 0.01 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0001 0.0001
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0066 0.0038 0.0036
Schistosoma mansoni hypothetical protein 0.0066 0.0038 0.0036
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.3912 1 1
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0066 0.0038 0.5
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0066 0.0038 0.0036
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0066 0.0038 0.0036
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0066 0.0038 0.0062
Echinococcus multilocularis phosphoglycerate mutase 0.0066 0.0038 0.0036
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0066 0.0038 0.5
Trypanosoma brucei mitotic cyclin 6 0.009 0.01 0.0098
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0001 0.0001
Trypanosoma cruzi cyclin 6, putative 0.009 0.01 0.0098
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.1669 0.419 0.419
Trypanosoma brucei phosphoglycerate mutase, putative 0.0066 0.0038 0.0036
Trichomonas vaginalis cyclin B, putative 0.009 0.01 1
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.3846 0.9829 0.9829
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0038 0.368
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0066 0.0038 0.0036
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0001 0.0001
Plasmodium vivax phosphoglucomutase-2, putative 0.0066 0.0038 1
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0066 0.0038 0.0036
Mycobacterium leprae conserved hypothetical protein 0.0066 0.0038 0.5
Leishmania major phosphoglycerate mutase, putative 0.0066 0.0038 0.0036
Trichomonas vaginalis cyclins, putative 0.009 0.01 1
Echinococcus granulosus phosphoglycerate mutase 0.0066 0.0038 0.0036
Schistosoma mansoni hypothetical protein 0.0066 0.0038 0.0036
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0066 0.0038 0.5
Loa Loa (eye worm) hypothetical protein 0.3846 0.9829 0.9829
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0038
Mycobacterium leprae Possible phosphoglycerate mutase 0.0066 0.0038 0.5
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0066 0.0038 0.368
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.3846 0.9829 0.9829
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0066 0.0038 0.0036
Schistosoma mansoni hypothetical protein 0.0066 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.3912 1 1
Brugia malayi phosphoglycerate mutase family protein 0.0066 0.0038 0.368
Giardia lamblia Hypothetical protein 0.2309 0.5847 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0066 0.0038 0.0062
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0066 0.0038 0.0036
Mycobacterium leprae conserved hypothetical protein 0.0066 0.0038 0.5
Trichomonas vaginalis cyclins, putative 0.0062 0.0026 0.2487
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1669 0.419 0.419
Toxoplasma gondii phosphoglycerate mutase family protein 0.0066 0.0038 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.01 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0038
Echinococcus granulosus phosphoglycerate mutase 0.0066 0.0038 0.0036
Trypanosoma cruzi cyclin, putative 0.009 0.01 0.0098
Trichomonas vaginalis cyclins, putative 0.009 0.01 1
Echinococcus multilocularis phosphoglycerate mutase 0.0066 0.0038 0.0036
Toxoplasma gondii phosphoglycerate mutase 0.0066 0.0038 1
Leishmania major cyclin 0.009 0.01 0.0098
Plasmodium vivax phosphoglycerate mutase, putative 0.0066 0.0038 1
Echinococcus granulosus phosphoglycerate mutase 0.0066 0.0038 0.0036
Trichomonas vaginalis cyclins, putative 0.009 0.01 1
Giardia lamblia Hypothetical protein 0.2309 0.5847 1
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0066 0.0038 0.0036
Toxoplasma gondii phosphoglycerate mutase family protein 0.0066 0.0038 1
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0066 0.0038 0.0036
Trichomonas vaginalis cyclin A, putative 0.009 0.01 1
Trypanosoma brucei glycerolphosphate mutase, putative 0.0066 0.0038 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0038 0.368
Echinococcus granulosus phosphoglycerate mutase 0.0066 0.0038 0.0036
Schistosoma mansoni phosphoglycerate mutase 0.0066 0.0038 0.0036
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0066 0.0038 0.0036
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0066 0.0038 0.0036
Toxoplasma gondii phosphoglycerate mutase family protein 0.0066 0.0038 1
Brugia malayi phosphoglycerate mutase family protein 0.0066 0.0038 0.368
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0066 0.0038 0.0036
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.01 0.0168
Leishmania major phosphoglycerate mutase family member 5, putative 0.0066 0.0038 0.0036
Leishmania major glycerolphosphate mutase, putative 0.0066 0.0038 0.0036
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0066 0.0038 0.368
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1669 0.419 0.419
Echinococcus multilocularis phosphoglycerate mutase 0.0066 0.0038 0.0036
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0066 0.0038 0.5
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.2309 0.5847 1
Trichomonas vaginalis cyclin B, putative 0.009 0.01 1
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0066 0.0038 0.0036
Schistosoma mansoni phosphoglycerate mutase 0.0066 0.0038 0.0036
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.2309 0.5847 1
Entamoeba histolytica cyclin, putative 0.009 0.01 0.0168
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0066 0.0038 1
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0066 0.0038 0.0036
Schistosoma mansoni hypothetical protein 0.0066 0.0038 0.0036
Treponema pallidum phosphoglyceromutase 0.0066 0.0038 0.5
Loa Loa (eye worm) hypothetical protein 0.009 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.2243 0.5676 0.5676
Loa Loa (eye worm) hypothetical protein 0.0052 0.0002 0.0002
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0066 0.0038 0.368
Echinococcus granulosus cyclin B 0.009 0.01 0.0098
Leishmania major hypothetical protein, conserved 0.0066 0.0038 0.0036
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0066 0.0038 0.0036
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0066 0.0038 0.0036
Mycobacterium leprae probable isochorismate synthase EntC 0.0066 0.0038 0.5
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0066 0.0038 0.0036
Mycobacterium tuberculosis Conserved protein 0.0066 0.0038 0.5
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0066 0.0038 0.5
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0066 0.0038 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0038 0.5
Brugia malayi UBASH3A protein homolog 0.0066 0.0038 0.368
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0066 0.0038 0.0036
Leishmania major phosphoglycerate mutase protein, putative 0.0066 0.0038 0.0036
Leishmania major hypothetical protein, conserved 0.0066 0.0038 0.0036
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0066 0.0038 0.0036
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.3846 0.9829 0.9829
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0066 0.0038 0.0036
Schistosoma mansoni hypothetical protein 0.0066 0.0038 0.0036

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.081 Inhibition of CDK2/Cyclin A ChEMBL. 18037537
IC50 (binding) = 83 nM In vitro inhibitory concentration against cyclin-dependent kinase 2-cyclin A complex using ATP/P33gamma-ATP mix as radioligand ChEMBL. 15189033
IC50 (binding) = 83 nM In vitro inhibitory concentration against cyclin-dependent kinase 2-cyclin A complex using ATP/P33gamma-ATP mix as radioligand ChEMBL. 15189033
IC50 (binding) = 83 nM Inhibition of CDK2/Cyclin A ChEMBL. 18037537

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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