Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0092 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0082 | 0.7411 | 0.5 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0092 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0091 | 0.995 | 0.5 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0091 | 0.995 | 0.5 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0092 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0092 | 1 | 0.5 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0092 | 1 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0092 | 1 | 0.5 |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0092 | 1 | 1 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0092 | 1 | 0.5 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0054 | 0 | 0.5 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0054 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0054 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.