Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0335 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0035 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 6.2 uM | Effective dose required for relaxation of the 30 mM KCl-induced contraction of rat aortic rings | ChEMBL. | 12852765 |
IC50 (functional) | < 1 uM | Concentration required to inhibit insulin release in rat | ChEMBL. | 12852765 |
ND (functional) | 0 | Inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 0.1 microM concentration; Not determined | ChEMBL. | 12852765 |
RIS (functional) | = 4.6 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 50 microM concentration | ChEMBL. | 12852765 |
RIS (functional) | = 6.5 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 10 microM concentration | ChEMBL. | 12852765 |
RIS (functional) | = 38.1 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 1 microM concentration | ChEMBL. | 12852765 |
Selectivity (functional) | > 6 | Estimated selectivity ratio of ED50 and IC50 in rat was calculated | ChEMBL. | 12852765 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.