Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0259 | 0.9983 | 0.9913 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0235 | 0.7993 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0259 | 0.9983 | 1 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0235 | 0.7993 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0259 | 0.9983 | 0.9913 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0235 | 0.7993 | 0.5 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0139 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0259 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0235 | 0.7993 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0139 | 0 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0259 | 0.9983 | 0.5 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0139 | 0 | 0.5 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0139 | 0 | 0.5 |
Onchocerca volvulus | 0.0259 | 1 | 0.5 | |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0235 | 0.7993 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0259 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0139 | 0 | 0.5 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0235 | 0.7993 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.5941 | 0.4808 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0214 | 0.6257 | 0.5214 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0235 | 0.7993 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.