Detailed information for compound 1872795

Basic information

Technical information
  • TDR Targets ID: 1872795
  • Name: 1-ethyl-3-methylimidazol-3-ium; hydrogen sulf ate
  • MW: 208.235 | Formula: C6H12N2O4S
  • H donors: 2 H acceptors: 4 LogP: -0.93 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]S(=O)(=O)O.CCn1cc[n+](c1)C
  • InChi: 1S/C6H11N2.H2O4S/c1-3-8-5-4-7(2)6-8;1-5(2,3)4/h4-6H,3H2,1-2H3;(H2,1,2,3,4)/q+1;/p-1
  • InChiKey: HZKDSQCZNUUQIF-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 1-ethyl-3-methyl-imidazol-3-ium; hydrogen sulfate
  • 1-ethyl-3-methyl-imidazol-3-ium bisulfate
  • 1-Ethyl-3-methylimidazolium hydrogen sulfate
  • 56486_FLUKA
  • BASIONIC AC 25

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0366 0.1256 0.189
Brugia malayi Cell death protein 3 precursor 0.0106 0.0326 0.0655
Brugia malayi 6-phosphofructokinase 0.0125 0.0396 0.0796
Echinococcus multilocularis Ankyrin 0.0017 0.0007 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0069 0.0305
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0075 0.0169
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0015
Schistosoma mansoni 6-phosphofructokinase 0.0125 0.0396 0.0586
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.034 0.1164 0.33
Echinococcus granulosus caspase 2 0.0106 0.0326 0.0481
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0006 0.0008
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0073 0.0209 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0075 0.0169
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0125 0.0396 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0008
Brugia malayi Hemopexin family protein 0.0028 0.0049 0.0098
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.034 0.1164 0.33
Brugia malayi Pre-SET motif family protein 0.0215 0.0715 0.144
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0236 0.079 0.2918
Plasmodium vivax SET domain protein, putative 0.0031 0.0058 0.0057
Brugia malayi Peptidase family M1 containing protein 0.0494 0.1714 0.3453
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Onchocerca volvulus Matrix metalloproteinase homolog 0.0045 0.0107 0.0297
Trypanosoma cruzi aminopeptidase, putative 0.0494 0.1714 0.4883
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0129 0.041 0.1132
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0075 0.0075
Loa Loa (eye worm) matrix metalloproteinase 0.002 0.0019 0.0028
Loa Loa (eye worm) matrixin family protein 0.0049 0.0121 0.0182
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.2808 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0075 0.0104
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0262 0.0884 0.3226
Echinococcus multilocularis flap endonuclease 1 0.003 0.0055 0.0073
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0236 0.079 0.2918
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0075 0.0221
Trypanosoma cruzi Aminopeptidase M1, putative 0.0494 0.1714 0.4883
Toxoplasma gondii exonuclease III APE 0.0019 0.0017 0.0017
Schistosoma mansoni aminopeptidase A (M01 family) 0.034 0.1164 0.1744
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0075 0.0075
Echinococcus granulosus puromycin sensitive aminopeptidase 0.034 0.1164 0.1744
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0075 0.0169
Toxoplasma gondii microneme protein MIC4 0.0016 0.0006 0.0006
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0069 0.0069
Onchocerca volvulus 0.0494 0.1714 0.5028
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0051 0.0035
Leishmania major hypothetical protein, conserved 0.0029 0.0051 0.01
Brugia malayi Matrixin family protein 0.002 0.0019 0.0038
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0007 0.000000012132
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0129 0.041 0.1132
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0649 0.227 0.6481
Schistosoma mansoni hypothetical protein 0.0028 0.0049 0.0064
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0075 0.0075
Echinococcus multilocularis inhibitor of apoptosis protein 0.0139 0.0445 0.066
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0494 0.1714 0.2572
Brugia malayi Kringle domain containing protein 0.0059 0.0159 0.032
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0048 0.0118 0.0168
Trypanosoma brucei Aminopeptidase M1, putative 0.0494 0.1714 0.4883
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0026 0.0029
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0075 0.0169
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.076 0.2668 0.2668
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0052
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0047 0.007
Brugia malayi phosphofructokinase 0.0125 0.0396 0.0796
Toxoplasma gondii thioredoxin reductase 0.0103 0.0317 0.0317
Brugia malayi Peptidase family M1 containing protein 0.034 0.1164 0.2344
Brugia malayi hypothetical protein 0.1401 0.4964 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0007 0.000000012132
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0494 0.1714 0.2572
Onchocerca volvulus 0.0059 0.0159 0.0451
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0006 0.0006
Echinococcus multilocularis 6 phosphofructokinase 0.0125 0.0396 0.0586
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.034 0.1164 0.6759
Schistosoma mansoni intermediate filament proteins 0.0028 0.0047 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0075 0.0169
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0494 0.1714 0.4883
Trichomonas vaginalis phosphofructokinase, putative 0.0125 0.0396 0.2233
Leishmania major ATP-dependent phosphofructokinase 0.0125 0.0396 0.1091
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0069 0.0305
Brugia malayi intermediate filament protein 0.0028 0.0047 0.0093
Loa Loa (eye worm) hypothetical protein 0.0059 0.0159 0.0239
Mycobacterium ulcerans leucyl aminopeptidase 0.076 0.2668 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0008
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1871 0.6645 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0007 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0075 0.0169
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0494 0.1714 0.4883
Toxoplasma gondii microneme protein MIC17A 0.0016 0.0006 0.0006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0262 0.0884 0.3272
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0069 0.0305
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0007 0.0002
Brugia malayi 6-phosphofructokinase 0.0125 0.0396 0.0796
Toxoplasma gondii kringle domain-containing protein 0.0059 0.0159 0.0159
Onchocerca volvulus 0.0965 0.3403 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0317 0.1132
Mycobacterium tuberculosis Probable reductase 0.0236 0.079 0.2918
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0129 0.041 0.1132
Brugia malayi hypothetical protein 0.0019 0.0015 0.0028
Entamoeba histolytica phosphofructokinase, putative 0.0125 0.0396 0.2233
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0017 0.0032
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0075 0.0027
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0069 0.0068
Echinococcus granulosus lamin dm0 0.0028 0.0047 0.0061
Plasmodium falciparum thioredoxin reductase 0.0036 0.0075 0.0059
Brugia malayi Matrixin family protein 0.0049 0.0121 0.0243
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0006 0.0006
Brugia malayi Death domain containing protein 0.0017 0.0007 0.0012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0058 0.0077
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.076 0.2668 1
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0317 0.0864
Onchocerca volvulus 0.0139 0.0445 0.1291
Brugia malayi hypothetical protein 0.014 0.045 0.0905
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0129 0.041 0.0825
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0649 0.227 0.6481
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.076 0.2668 1
Brugia malayi hypothetical protein 0.0029 0.0051 0.0102
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0075 0.0104
Plasmodium falciparum glutathione reductase 0.0036 0.0075 0.0059
Echinococcus granulosus intermediate filament protein 0.0028 0.0047 0.0061
Loa Loa (eye worm) hypothetical protein 0.0139 0.0445 0.0668
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0075 0.0169
Brugia malayi Protein kinase domain containing protein 0.0059 0.0159 0.032
Toxoplasma gondii aminopeptidase N protein 0.2808 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0028
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0006 0.0008
Schistosoma mansoni leucine aminopeptidase 0.0129 0.041 0.0608
Brugia malayi Pre-SET motif family protein 0.0031 0.0058 0.0115
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0075 0.0059
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0154 0.0498 0.074
Entamoeba histolytica Flap nuclease, putative 0.003 0.0055 0.0224
Plasmodium falciparum glutathione reductase 0.0103 0.0317 0.0301
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0069 0.0069
Echinococcus multilocularis leucyl aminopeptidase 0.0129 0.041 0.0608
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0502 0.1744 0.2617
Schistosoma mansoni hypothetical protein 0.0106 0.0326 0.0481
Echinococcus granulosus inhibitor of apoptosis protein 0.0139 0.0445 0.066
Echinococcus granulosus apoptotic protease activating factor 1 0.0106 0.0326 0.0481
Echinococcus granulosus leucine aminopeptidase protein 0.076 0.2668 0.401
Brugia malayi glutathione reductase 0.0103 0.0317 0.0637
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0075 0.0169
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.001
Echinococcus granulosus flap endonuclease 1 0.003 0.0055 0.0073
Onchocerca volvulus Matrilysin homolog 0.0045 0.0107 0.0297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0075 0.0169
Onchocerca volvulus 0.0031 0.0058 0.0151
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0028
Loa Loa (eye worm) TATA binding protein associated factor 0.034 0.1164 0.1751
Echinococcus granulosus Ankyrin 0.0017 0.0007 0.0001
Mycobacterium ulcerans aminopeptidase N PepN 0.034 0.1164 0.4327
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0129 0.041 0.1132
Onchocerca volvulus 0.0106 0.0326 0.0941
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0058 0.0077
Schistosoma mansoni hypothetical protein 0.0139 0.0445 0.066
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0075 0.0169
Onchocerca volvulus 0.0028 0.0049 0.0127
Plasmodium falciparum M17 leucyl aminopeptidase 0.0649 0.227 0.2257
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0058 0.0077
Echinococcus multilocularis leucyl aminopeptidase 0.0129 0.041 0.0608
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0139 0.0445 0.066
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0129 0.041 0.0608
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0069 0.0305
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0075 0.0104
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.034 0.1164 0.33
Loa Loa (eye worm) hypothetical protein 0.0472 0.1637 0.2462
Onchocerca volvulus 0.034 0.1164 0.3408
Trypanosoma brucei aminopeptidase, putative 0.034 0.1164 0.33
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0047 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0069 0.0305
Echinococcus multilocularis musashi 0.0028 0.0047 0.0061
Mycobacterium ulcerans aminopeptidase N PepN 0.0494 0.1714 0.6402
Loa Loa (eye worm) hypothetical protein 0.0626 0.2187 0.329
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0129 0.041 0.1132
Brugia malayi POT family protein 0.0047 0.0116 0.0232
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0139 0.0445 0.066
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0075 0.0221
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0106 0.0326 0.049
Loa Loa (eye worm) hypothetical protein 0.034 0.1164 0.1751
Onchocerca volvulus Matrilysin homolog 0.002 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.0106 0.0326 0.049
Echinococcus multilocularis lamin dm0 0.0028 0.0047 0.0061
Onchocerca volvulus Cell death protein 3 homolog 0.0106 0.0326 0.0941
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0129 0.041 0.1132
Toxoplasma gondii aminopeptidase n, putative 0.2808 1 1
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0236 0.079 0.2918
Brugia malayi hypothetical protein 0.0106 0.0326 0.0655
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0125 0.0396 0.1091
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0069 0.0052
Echinococcus multilocularis caspase 2 0.0106 0.0326 0.0481
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0007 0.0001
Leishmania major trypanothione reductase 0.0103 0.0317 0.0864
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0096 0.0134
Brugia malayi TATA binding protein associated factor 0.034 0.1164 0.2344
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1871 0.6645 1
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0317 0.0476
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0129 0.041 0.0616
Loa Loa (eye worm) aminopeptidase N 0.0494 0.1714 0.2579
Leishmania major hypothetical protein, conserved 0.0059 0.0159 0.041
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0055 0.6486
Brugia malayi Peptidase family M1 containing protein 0.0965 0.3403 0.6856
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0317 0.0467
Plasmodium falciparum flap endonuclease 1 0.003 0.0055 0.0038
Brugia malayi Uncoordinated protein 44 0.0017 0.0007 0.0012
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0125 0.0396 0.1091
Loa Loa (eye worm) glutathione reductase 0.0103 0.0317 0.0476
Loa Loa (eye worm) hypothetical protein 0.034 0.1164 0.1751
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0649 0.227 0.6481
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.099 0.3493 1
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.076 0.2668 1
Entamoeba histolytica hypothetical protein 0.0041 0.0096 0.0466
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0125 0.0396 0.143
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0125 0.0396 0.2233
Mycobacterium ulcerans 6-phosphofructokinase 0.0125 0.0396 0.143
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0075 0.0169
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0008
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0069 0.1366
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0236 0.079 0.2869
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0139 0.0445 0.066
Onchocerca volvulus 0.0244 0.0822 0.2401
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0051 0.01
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0069 0.0052
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0006 0.0008
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.034 0.1164 0.33
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0026 0.0051
Schistosoma mansoni inhibitor of apoptosis protein 0.0139 0.0445 0.066
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0075 0.0221
Toxoplasma gondii PAN/Apple domain-containing protein 0.0016 0.0006 0.0006
Echinococcus multilocularis leucyl aminopeptidase 0.0129 0.041 0.0608
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0051 0.01
Loa Loa (eye worm) POT family protein 0.0047 0.0116 0.0173
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0715 0.1076
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0129 0.041 0.0616
Schistosoma mansoni hypothetical protein 0.0053 0.0138 0.0198
Loa Loa (eye worm) hypothetical protein 0.0154 0.0498 0.0748
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0017 0.0016
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0494 0.1714 0.2572
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0494 0.1714 1
Toxoplasma gondii hypothetical protein 0.0016 0.0006 0.0006
Schistosoma mansoni caspase-7 (C14 family) 0.0106 0.0326 0.0481
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0006 0.0008
Echinococcus granulosus leucyl aminopeptidase 0.0129 0.041 0.0608
Echinococcus granulosus puromycin sensitive aminopeptidase 0.034 0.1164 0.1744
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0069 0.0069
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.099 0.3493 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0494 0.1714 0.2572
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0016 0.0006 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0075 0.0169
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0069 0.0305
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0041 0.0096 0.0134
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0007 0.000000012132
Mycobacterium tuberculosis Probable dehydrogenase 0.0236 0.079 0.2918
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.034 0.1164 0.33
Trypanosoma brucei Aminopeptidase M1, putative 0.0494 0.1714 0.4883
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0096 0.0134
Loa Loa (eye worm) hypothetical protein 0.034 0.1164 0.1751
Onchocerca volvulus 0.002 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0028
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0129 0.041 0.0608
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0069 0.8824
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0317 0.0316
Trypanosoma brucei trypanothione reductase 0.0103 0.0317 0.0864
Brugia malayi Flap endonuclease-1 0.003 0.0055 0.0109
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0086
Echinococcus multilocularis tissue type plasminogen activator 0.0059 0.0159 0.023
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0055 0.0109
Trichomonas vaginalis set domain proteins, putative 0.0244 0.0821 0.474
Onchocerca volvulus 0.0028 0.0047 0.012
Echinococcus granulosus leukotriene A 4 hydrolase 0.1871 0.6645 1
Echinococcus granulosus 6 phosphofructokinase 0.0125 0.0396 0.0586
Loa Loa (eye worm) 6-phosphofructokinase 0.0125 0.0396 0.0595
Echinococcus granulosus lamin 0.0028 0.0047 0.0061
Plasmodium falciparum cysteine repeat modular protein 1 0.0059 0.0159 0.0143
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0055 0.0109
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0006 0.0006
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0075 0.0169
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0075 0.0169
Entamoeba histolytica phosphofructokinase, putative 0.0125 0.0396 0.2233
Brugia malayi hypothetical protein 0.0041 0.0096 0.0192
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.007
Toxoplasma gondii subtilisin SUB12 0.0016 0.0006 0.0006
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0024 0.0035 0.0069
Entamoeba histolytica hypothetical protein 0.0041 0.0096 0.0466
Toxoplasma gondii leucyl aminopeptidase LAP 0.076 0.2668 0.2668
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.001 0.0004
Schistosoma mansoni lamin 0.0028 0.0047 0.0061
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0058 0.0077
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0006 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0058 0.0077
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0494 0.1714 0.2572
Brugia malayi hypothetical protein 0.034 0.1164 0.2344
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0051 0.0051
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.099 0.3493 1
Echinococcus granulosus tissue type plasminogen activator 0.0059 0.0159 0.023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0008
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0129 0.041 0.0825
Echinococcus multilocularis leucine aminopeptidase protein 0.076 0.2668 0.401
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0139 0.0445 0.0668
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0154 0.0498 0.1383
Mycobacterium tuberculosis Probable oxidoreductase 0.0262 0.0884 0.3272
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0059 0.0159 0.0159
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0494 0.1714 0.4883
Toxoplasma gondii aminopeptidase N, putative 0.2808 1 1
Loa Loa (eye worm) matrixin family protein 0.0045 0.0107 0.016
Toxoplasma gondii microneme protein, putative 0.0016 0.0006 0.0006
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0006 0.0006
Brugia malayi Matrixin family protein 0.002 0.0019 0.0038
Brugia malayi Matrixin family protein 0.002 0.0019 0.0038
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0006 0.0006
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0055 0.0054
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0041 0.0082
Trypanosoma cruzi aminopeptidase, putative 0.034 0.1164 0.33
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0075 0.0221
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.002 0.0019 0.0019
Echinococcus multilocularis aminopeptidase N 0.0965 0.3403 0.5117
Toxoplasma gondii microneme protein MIC17B 0.0016 0.0006 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0494 0.1714 0.2572
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.034 0.1164 0.1744
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0017 0.0024
Plasmodium falciparum thioredoxin reductase 0.0103 0.0317 0.0301
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0159 0.041
Brugia malayi cytosol aminopeptidase 0.0129 0.041 0.0825
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0055 0.0224
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0075 0.0151
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0096 0.0134
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0051 0.0035
Loa Loa (eye worm) 6-phosphofructokinase 0.0125 0.0396 0.0595
Entamoeba histolytica aminopeptidase, putative 0.0494 0.1714 1
Brugia malayi Thioredoxin reductase 0.0103 0.0317 0.0637
Entamoeba histolytica hypothetical protein 0.0041 0.0096 0.0466
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0067
Brugia malayi Matrixin family protein 0.002 0.0019 0.0038
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0494 0.1714 0.2572
Trypanosoma brucei aminopeptidase, putative 0.0129 0.041 0.1132
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0055 0.0109
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0047 0.007
Brugia malayi PAN domain containing protein 0.0016 0.0006 0.0011
Onchocerca volvulus Deterin homolog 0.0139 0.0445 0.1291
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0007 0.0009
Brugia malayi hypothetical protein 0.0494 0.1714 0.3453
Entamoeba histolytica hypothetical protein 0.0041 0.0096 0.0466
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0139 0.0445 0.0895
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0058 0.0077
Schistosoma mansoni lamin 0.0028 0.0047 0.0061
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0024 0.0035 0.0069
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0236 0.079 0.2918
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0075 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0069 0.0068
Echinococcus multilocularis lamin 0.0028 0.0047 0.0061
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.034 0.1164 0.1149
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0055 0.0055
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0262 0.0884 0.3272
Loa Loa (eye worm) TK/ROR protein kinase 0.0059 0.0159 0.0239
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0494 0.1714 0.2572
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0129 0.041 0.0825
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0129 0.041 0.1132
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0017 0.0015
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0075 0.0346
Echinococcus granulosus nuclear factor of activated T cells 5 0.0085 0.0251 0.0368
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0139 0.0445 0.0895
Trichomonas vaginalis phosphofructokinase, putative 0.0125 0.0396 0.2233
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0051 0.01
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0026 0.0055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0017 0.0015
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0075 0.0346
Echinococcus granulosus leucyl aminopeptidase 0.0129 0.041 0.0608
Schistosoma mansoni 6-phosphofructokinase 0.0125 0.0396 0.0586
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0075 0.0221
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0494 0.1714 0.4883
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0053 0.007
Schistosoma mansoni flap endonuclease-1 0.0027 0.0045 0.0057
Brugia malayi Protein kinase domain containing protein 0.0017 0.0007 0.0012
Echinococcus multilocularis expressed conserved protein 0.0048 0.0121 0.0171
Loa Loa (eye worm) PAN domain-containing protein 0.0016 0.0006 0.0008
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1871 0.6645 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0812 0.2853 0.4293
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0494 0.1714 0.2572
Loa Loa (eye worm) phosphofructokinase 0.0125 0.0396 0.0595
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0073 0.0209 0.0305
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.099 0.3493 1
Schistosoma mansoni hypothetical protein 0.0059 0.0159 0.023
Entamoeba histolytica phosphofructokinase, putative 0.0125 0.0396 0.2233
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0075 0.0221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0058 0.0077
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.034 0.1164 0.1164
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0154 0.0498 0.074
Loa Loa (eye worm) RecQ helicase 0.0022 0.0026 0.0038
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0494 0.1714 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0069 0.0305
Echinococcus granulosus aminopeptidase N 0.0965 0.3403 0.5117
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0069 0.0305
Echinococcus multilocularis apoptotic protease activating factor 1 0.0106 0.0326 0.0481
Toxoplasma gondii hypothetical protein 0.0016 0.0006 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0494 0.1714 0.2572
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.034 0.1164 0.33
Echinococcus granulosus bloom syndrome protein 0.0022 0.0026 0.0029
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0075 0.0169
Toxoplasma gondii microneme protein MIC17C 0.0016 0.0006 0.0006
Echinococcus granulosus expressed conserved protein 0.0048 0.0121 0.0171
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0494 0.1714 0.2572
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0041 0.0082
Trichomonas vaginalis phosphofructokinase, putative 0.0125 0.0396 0.2233
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0055 0.0081
Treponema pallidum NADH oxidase 0.0036 0.0075 0.1548
Loa Loa (eye worm) hypothetical protein 0.0154 0.0498 0.0748
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0076
Mycobacterium ulcerans hydrolase 0.0024 0.0035 0.0069
Chlamydia trachomatis cytosol aminopeptidase 0.076 0.2668 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0085 0.0251 0.0368
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0008
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0649 0.227 0.6481
Plasmodium vivax glutathione reductase, putative 0.0103 0.0317 0.0316
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0026 0.0055
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0317 0.0467
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0125 0.0396 0.137
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0075 0.0169
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0075 0.0059
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0075 0.0169
Onchocerca volvulus 0.0028 0.0047 0.012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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