Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.017 | 0.0711 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0092 | 0.0242 | 0.1272 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0168 | 0.0698 | 0.976 |
Brugia malayi | thymidylate synthase | 0.017 | 0.0711 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 0.5 |
Brugia malayi | WGR domain containing protein | 0.0168 | 0.0698 | 0.9757 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1715 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.017 | 0.0711 | 0.0547 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0175 | 0.0737 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0168 | 0.0698 | 0.5 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0092 | 0.0242 | 0.34 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0168 | 0.0698 | 0.9816 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0242 | 0.251 |
Brugia malayi | WGR domain containing protein | 0.0092 | 0.0242 | 0.1272 |
Onchocerca volvulus | 0.017 | 0.0711 | 0.5 | |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0168 | 0.0698 | 0.9721 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0092 | 0.0242 | 0.1272 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.0173 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.017 | 0.0711 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0456 | 0.5933 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0092 | 0.0242 | 0.1379 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1715 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.017 | 0.0711 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.017 | 0.0711 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.017 | 0.0711 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.