TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.428 | Formula: C20H22N6O2
H donors: 2 H acceptors: 4 LogP: 4.09 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(n1nc(C)n(nc1C)C(=O)Nc1ccc(cc1)C)Nc1ccc(cc1)C
InChi: 1S/C20H22N6O2/c1-13-5-9-17(10-6-13)21-19(27)25-15(3)24-26(16(4)23-25)20(28)22-18-11-7-14(2)8-12-18/h5-12H,1-4H3,(H,21,27)(H,22,28)
InChiKey: DCUQGRMJMCRWDK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0501	0.7101	0.7046
Brugia malayi	Tubulin alpha-2 chain	0.0501	0.7101	0.7101
Giardia lamblia	Alpha-tubulin	0.0501	0.7101	0.6397
Echinococcus granulosus	beta tubulin	0.0694	1	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0501	0.7101	0.7101
Echinococcus granulosus	peroxisome assembly protein 26	0.0501	0.7101	0.7046
Echinococcus multilocularis	tubulin alpha	0.0366	0.507	0.4976
Giardia lamblia	Beta tubulin	0.0694	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0501	0.7101	0.7046
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0427	0.0427
Trypanosoma cruzi	epsilon tubulin, putative	0.0366	0.507	0.507
Echinococcus granulosus	beta tubulin	0.0694	1	1
Echinococcus multilocularis	geminin	0.0195	0.2499	0.2356
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0501	0.7101	0.7046
Leishmania major	delta tubulin, putative	0.0159	0.1954	0.1954
Trypanosoma brucei	zeta tubulin	0.0159	0.1954	0.1954
Schistosoma mansoni	tubulin subunit beta	0.0159	0.1954	0.1829
Trichomonas vaginalis	tubulin, putative	0.0694	1	1
Brugia malayi	hypothetical protein	0.0174	0.2181	0.2181
Trypanosoma cruzi	alpha tubulin, putative	0.0501	0.7101	0.7101
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0159	0.1954	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0154	0.0154
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0427	0.0427
Schistosoma mansoni	tubulin subunit alpha	0.0501	0.7101	0.7056
Echinococcus multilocularis	tubulin alpha chain	0.0501	0.7101	0.7046
Echinococcus granulosus	Tubulin beta 2C chain	0.0694	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0159	0.1954	0.1954
Loa Loa (eye worm)	tubulin gamma chain	0.0366	0.507	0.507
Leishmania major	beta tubulin	0.0694	1	1
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Echinococcus granulosus	Tubulin beta 2C chain	0.0694	1	1
Leishmania major	beta tubulin	0.0694	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0501	0.7101	0.7046
Brugia malayi	beta-tubulin, identical	0.0694	1	1
Trypanosoma brucei	alpha tubulin	0.0501	0.7101	0.7101
Plasmodium vivax	tubulin beta chain, putative	0.0694	1	1
Leishmania major	zeta tubulin, putative	0.0159	0.1954	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0154	0.0154
Echinococcus granulosus	Tubulin beta 2C chain	0.0694	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0694	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0501	0.7101	0.6397
Loa Loa (eye worm)	tubulin beta-4 chain	0.0694	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0501	0.7101	0.6397
Loa Loa (eye worm)	tubulin beta chain	0.0159	0.1954	0.1954
Echinococcus granulosus	tubulin epsilon chain	0.0366	0.507	0.4976
Echinococcus multilocularis	tubulin alpha 1C chain	0.0501	0.7101	0.7046
Brugia malayi	Tubulin alpha-2 chain	0.0501	0.7101	0.7101
Schistosoma mansoni	tubulin subunit gamma	0.0366	0.507	0.4993
Echinococcus multilocularis	Tubulin beta 2C chain	0.0694	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0187	0.0033
Echinococcus granulosus	tubulin alpha chain	0.0501	0.7101	0.7046
Loa Loa (eye worm)	tubulin alpha 2	0.0342	0.471	0.471
Entamoeba histolytica	tubulin alpha chain, putative	0.0501	0.7101	0.7046
Loa Loa (eye worm)	tubulin beta-1 chain	0.0694	1	1
Schistosoma mansoni	tubulin subunit beta	0.0694	1	1
Echinococcus multilocularis	tubulin epsilon chain	0.0366	0.507	0.4976
Echinococcus granulosus	tubulin subunit TubB	0.0501	0.7101	0.7046
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0501	0.7101	0.6397
Trichomonas vaginalis	tubulin alpha chain, putative	0.0366	0.507	0.3872
Entamoeba histolytica	tubulin family protein	0.0694	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0294	0.3986	0.2525
Loa Loa (eye worm)	tubulin beta-2A chain	0.0694	1	1
Plasmodium falciparum	alpha tubulin 2	0.0501	0.7101	0.7101
Schistosoma mansoni	tubulin subunit alpha	0.0501	0.7101	0.7056
Leishmania major	beta tubulin	0.0694	1	1
Echinococcus multilocularis	beta tubulin	0.0694	1	1
Echinococcus granulosus	tubulin delta chain	0.0159	0.1954	0.1801
Leishmania major	beta tubulin	0.0694	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0207	0.2679	0.0901
Leishmania major	beta tubulin	0.0694	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0366	0.507	0.3872
Plasmodium falciparum	tubulin beta chain	0.0694	1	1
Brugia malayi	MH2 domain containing protein	0.0138	0.1632	0.1632
Trichomonas vaginalis	tubulin beta chain, putative	0.0694	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0501	0.7101	0.7046
Echinococcus multilocularis	tubulin alpha chain	0.0501	0.7101	0.7046
Trypanosoma brucei	beta tubulin	0.0366	0.507	0.507
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0342	0.471	0.471
Trichomonas vaginalis	tubulin gamma chain, putative	0.0694	1	1
Leishmania major	gamma-tubulin	0.0366	0.507	0.507
Trypanosoma brucei	alpha tubulin	0.0501	0.7101	0.7101
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Brugia malayi	Tubulin alpha chain	0.0159	0.1954	0.1954
Loa Loa (eye worm)	tubulin alpha 2	0.0342	0.471	0.471
Toxoplasma gondii	beta-tubulin, putative	0.0694	1	1
Leishmania major	beta tubulin	0.0694	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0366	0.507	0.507
Echinococcus multilocularis	beta tubulin	0.0694	1	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.0694	1	1
Echinococcus granulosus	tubulin alpha	0.0366	0.507	0.4976
Entamoeba histolytica	tubulin family protein	0.0694	1	1
Trypanosoma brucei	alpha tubulin	0.0501	0.7101	0.7101
Echinococcus granulosus	tubulin alpha chain	0.0501	0.7101	0.7046
Trypanosoma brucei	beta tubulin	0.0694	1	1
Schistosoma mansoni	alpha tubulin	0.0501	0.7101	0.7056
Brugia malayi	Tubulin alpha chain	0.0501	0.7101	0.7101
Echinococcus multilocularis	tubulin delta chain	0.0159	0.1954	0.1801
Brugia malayi	Tubulin beta chain	0.0207	0.2679	0.2679
Loa Loa (eye worm)	BEN-1 protein	0.0694	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0427	0.0427
Echinococcus granulosus	Tubulin beta 2C chain	0.0694	1	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0159	0.1954	0.5
Echinococcus granulosus	tubulin alpha chain	0.0501	0.7101	0.7046
Leishmania major	beta tubulin	0.0694	1	1
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Brugia malayi	tubulin alpha chain - mouse	0.0501	0.7101	0.7101
Echinococcus granulosus	tubulin alpha 1C chain	0.0501	0.7101	0.7046
Schistosoma mansoni	tubulin subunit beta	0.0694	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0501	0.7101	0.7101
Brugia malayi	tubulin alpha-2 chain	0.0501	0.7101	0.7101
Echinococcus multilocularis	Tubulin beta 2C chain	0.0694	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0501	0.7101	0.7046
Echinococcus granulosus	tubulin alpha chain	0.0501	0.7101	0.7046
Trichomonas vaginalis	tubulin beta chain, putative	0.0501	0.7101	0.6397
Entamoeba histolytica	tubulin gamma chain	0.0366	0.507	0.4976
Schistosoma mansoni	tubulin subunit beta	0.0694	1	1
Trypanosoma brucei	beta tubulin	0.0694	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0366	0.507	0.507
Echinococcus multilocularis	tubulin alpha chain	0.0501	0.7101	0.7046
Leishmania major	beta tubulin	0.0694	1	1
Loa Loa (eye worm)	beta-tubulin	0.0694	1	1
Giardia lamblia	Beta tubulin	0.0694	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0501	0.7101	0.7046
Echinococcus granulosus	Tubulin beta 2C chain	0.0694	1	1
Plasmodium falciparum	tubulin gamma chain	0.0366	0.507	0.507
Echinococcus multilocularis	tubulin beta 1 chain	0.0694	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0501	0.7101	0.7046
Plasmodium vivax	delta tubulin, putative	0.0159	0.1954	0.1954
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0342	0.471	0.3426
Plasmodium vivax	tubulin alpha chain, putative	0.0501	0.7101	0.7101
Leishmania major	beta tubulin	0.0694	1	1
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Loa Loa (eye worm)	tubulin alpha 2	0.0135	0.1595	0.1595
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Onchocerca volvulus		0.0207	0.2679	1
Trypanosoma brucei	alpha tubulin, putative	0.0207	0.2679	0.2679
Loa Loa (eye worm)	BEN-1 protein	0.0694	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0501	0.7101	0.6397
Plasmodium vivax	tubulin alpha chain, putative	0.0501	0.7101	0.7101
Trypanosoma cruzi	tubulin delta chain	0.0159	0.1954	0.1954
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0501	0.7101	0.6397
Schistosoma mansoni	tubulin subunit epsilon	0.0366	0.507	0.4993
Leishmania major	beta tubulin	0.0694	1	1
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Treponema pallidum	cell division protein FtsZ	0.0159	0.1954	0.5
Trichomonas vaginalis	tubulin, putative	0.0207	0.2679	0.0901
Echinococcus multilocularis	tubulin alpha 1C chain	0.0501	0.7101	0.7046
Echinococcus multilocularis	hypothetical protein	0.0501	0.7101	0.7046
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0694	1	1
Trypanosoma brucei	beta tubulin	0.0694	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0427	0.0427
Trichomonas vaginalis	tubulin alpha chain, putative	0.0694	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0694	1	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0294	0.3986	0.3986
Echinococcus granulosus	alpha tubulin	0.0501	0.7101	0.7046
Trichomonas vaginalis	tubulin beta chain, putative	0.0501	0.7101	0.6397
Toxoplasma gondii	beta-1 tubulin, putative	0.0694	1	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0366	0.507	0.4976
Echinococcus granulosus	Tubulin alpha 1 chain	0.0501	0.7101	0.7046
Schistosoma mansoni	tubulin subunit alpha	0.0501	0.7101	0.7056
Schistosoma mansoni	tubulin subunit delta	0.0159	0.1954	0.1829
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Trichomonas vaginalis	tubulin beta chain, putative	0.0501	0.7101	0.6397
Loa Loa (eye worm)	hypothetical protein	0.0174	0.2181	0.2181
Loa Loa (eye worm)	tubulin beta chain	0.0694	1	1
Brugia malayi	alpha-tubulin	0.0501	0.7101	0.7101
Echinococcus granulosus	geminin	0.0195	0.2499	0.2356
Trypanosoma cruzi	zeta tubulin, putative	0.0159	0.1954	0.1954
Trypanosoma cruzi	epsilon tubulin, putative	0.0366	0.507	0.507
Loa Loa (eye worm)	alpha-tubulin	0.0501	0.7101	0.7101
Trypanosoma brucei	epsilon tubulin	0.0366	0.507	0.507
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0159	0.1954	0.1954
Plasmodium vivax	tubulin gamma chain, putative	0.0366	0.507	0.507
Trypanosoma brucei	beta tubulin	0.0694	1	1
Brugia malayi	Cell division protein ftsZ	0.0159	0.1954	0.1954
Schistosoma mansoni	alpha tubulin	0.0501	0.7101	0.7056
Schistosoma mansoni	hypothetical protein	0.0195	0.2499	0.2382
Mycobacterium leprae	cell division protein FtsZ	0.0159	0.1954	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0207	0.2679	0.0901
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0207	0.2679	0.0901
Trichomonas vaginalis	tubulin alpha chain, putative	0.0207	0.2679	0.0901
Trypanosoma cruzi	beta tubulin, putative	0.0694	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0501	0.7101	0.6397
Schistosoma mansoni	tubulin subunit beta	0.0694	1	1
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Trypanosoma brucei	tubulin gamma chain	0.0366	0.507	0.507
Schistosoma mansoni	tubulin subunit beta	0.0694	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.0694	1	1
Schistosoma mansoni	tubulin subunit beta	0.0694	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0501	0.7101	0.7101
Echinococcus multilocularis	peroxisome assembly protein 26	0.0501	0.7101	0.7046
Leishmania major	beta tubulin	0.0694	1	1
Leishmania major	beta tubulin	0.0694	1	1
Leishmania major	beta tubulin	0.0694	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0501	0.7101	0.7101
Loa Loa (eye worm)	hypothetical protein	0.0342	0.471	0.471
Leishmania major	epsilon tubulin, putative	0.0366	0.507	0.507
Giardia lamblia	Beta tubulin	0.0694	1	1
Trypanosoma brucei	tubulin delta chain	0.0159	0.1954	0.1954
Brugia malayi	hypothetical protein	0.0041	0.0187	0.0187
Plasmodium falciparum	tubulin delta chain, putative	0.0159	0.1954	0.1954
Schistosoma mansoni	hypothetical protein	0.0195	0.2499	0.2382
Trypanosoma brucei	epsilon tubulin	0.0366	0.507	0.507
Leishmania major	beta tubulin	0.0694	1	1
Leishmania major	beta tubulin	0.0694	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0501	0.7101	0.7101
Echinococcus multilocularis	Tubulin beta 2C chain	0.0694	1	1
Brugia malayi	Tubulin gamma chain	0.0366	0.507	0.507
Trichomonas vaginalis	tubulin gamma chain, putative	0.0366	0.507	0.3872
Leishmania major	beta tubulin	0.0694	1	1
Plasmodium falciparum	alpha tubulin 1	0.0501	0.7101	0.7101
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Brugia malayi	Tubulin beta chain	0.0159	0.1954	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0294	0.3986	0.3986
Echinococcus multilocularis	tubulin subunit TubB	0.0501	0.7101	0.7046
Giardia lamblia	Alpha-tubulin	0.0501	0.7101	0.6397
Loa Loa (eye worm)	hypothetical protein	0.0501	0.7101	0.7101
Echinococcus multilocularis	tubulin alpha chain	0.0501	0.7101	0.7046
Schistosoma mansoni	alpha tubulin	0.0501	0.7101	0.7056
Giardia lamblia	Gamma tubulin	0.0366	0.507	0.3872
Toxoplasma gondii	beta tubulin	0.0694	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0138	0.1632	0.1632
Echinococcus multilocularis	Tubulin beta 2C chain	0.0694	1	1
Leishmania major	alpha tubulin	0.0501	0.7101	0.7101
Echinococcus granulosus	tubulin alpha 1C chain	0.0501	0.7101	0.7046
Trypanosoma cruzi	tubulin gamma chain	0.0366	0.507	0.507
Echinococcus granulosus	tubulin alpha chain	0.0501	0.7101	0.7046
Trypanosoma brucei	alpha tubulin	0.0501	0.7101	0.7101
Echinococcus granulosus	tubulin subunit beta	0.0694	1	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0366	0.507	0.4976
Trichomonas vaginalis	tubulin alpha chain, putative	0.0207	0.2679	0.0901
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0187	0.0033
Trypanosoma cruzi	tubulin delta chain	0.0159	0.1954	0.1954
Loa Loa (eye worm)	transcription factor SMAD2	0.0138	0.1632	0.1632
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0694	1	1
Trypanosoma brucei	epsilon tubulin	0.0366	0.507	0.507
Entamoeba histolytica	tubulin alpha-1 chain	0.0501	0.7101	0.7046
Trypanosoma brucei	zeta tubulin, putative	0.0159	0.1954	0.1954
Plasmodium vivax	tubulin epsilon chain, putative	0.0366	0.507	0.507
Trichomonas vaginalis	tubulin, putative	0.0207	0.2679	0.0901
Trypanosoma cruzi	zeta tubulin, putative	0.0159	0.1954	0.1954
Echinococcus multilocularis	tubulin subunit beta	0.0694	1	1
Leishmania major	beta tubulin	0.0694	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0501	0.7101	0.7046
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0159	0.1954	0.5
Leishmania major	beta tubulin	0.0694	1	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0501	0.7101	0.7101
Schistosoma mansoni	tubulin subunit alpha	0.0159	0.1954	0.1829
Echinococcus multilocularis	tubulin alpha 3 chain	0.0501	0.7101	0.7046

Activities

Activity type	Activity value	Assay description	Source	Reference
Rate of inhibition (functional)	= 0 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-8 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 0 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-8 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 3.1 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-6 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 3.1 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-7 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 3.1 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-6 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 3.1 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-7 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 4.7 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-5 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 4.7 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-5 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 6.2 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-6 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 6.2 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-6 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 7.7 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-7 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 7.7 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-7 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 9.2 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-5 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 9.2 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-5 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 12.3 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-8 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 12.3 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-8 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 24.6 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-4 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 24.6 %	In vitro rate of inhibition of A-549 tumor cell growth at 10E-4 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 73.4 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-4 mol/L	ChEMBL.	14980660
Rate of inhibition (functional)	= 73.4 %	In vitro rate of inhibition of P388 tumor cell growth at 10E-4 mol/L	ChEMBL.	14980660

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 18736