Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0219 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0219 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.7303 | 0.7303 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.7303 | 0.7303 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.7303 | 0.7303 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0219 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0219 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0219 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0219 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0219 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.7303 | 0.7303 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.7303 | 0.7303 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.7303 | 0.7303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 4.4668 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.